Adenylate cyclase produces cAMP

Stable Identifier
R-HSA-111930
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Adenylate cyclase is responsive to calcium and calmodulin and produces cAMP. One important physiological role for Calmodulin is the regulation of adenylylcyclases. Four of the ten known adenylylcyclases are calcium sensitive, in particular type 8 (AC8).
Literature References
PubMed ID Title Journal Year
10075700 Calmodulin-binding sites on adenylyl cyclase type VIII

Gu, C, Cooper, DM

J Biol Chem 1999
16613843 The role of calmodulin recruitment in Ca2+ stimulation of adenylyl cyclase type 8

Ciruela, A, Simpson, RE, Cooper, DM

J Biol Chem 2006
Participants
Participates
Catalyst Activity

calcium- and calmodulin-responsive adenylate cyclase activity of Adenylate cyclase (Mg2+ cofactor) [plasma membrane]

This event is regulated
Positively by
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
Cite Us!