Adenylate cyclase produces cAMP

Stable Identifier
R-HSA-111930
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Adenylate cyclase is responsive to calcium and calmodulin and produces cAMP. One important physiological role for Calmodulin is the regulation of adenylylcyclases. Four of the ten known adenylylcyclases are calcium sensitive, in particular type 8 (AC8).

Literature References
PubMed ID Title Journal Year
16613843 The role of calmodulin recruitment in Ca2+ stimulation of adenylyl cyclase type 8

Simpson, RE, Ciruela, A, Cooper, DM

J Biol Chem 2006
10075700 Calmodulin-binding sites on adenylyl cyclase type VIII

Gu, C, Cooper, DM

J Biol Chem 1999
Participants
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Catalyst Activity
Catalyst Activity
Title
calcium- and calmodulin-responsive adenylate cyclase activity of Adenylate cyclase (Mg2+ cofactor) [plasma membrane]
Physical Entity
Activity
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