Cam-PDE 1 activation

Stable Identifier
R-HSA-111957
Type
Pathway
Species
Homo sapiens
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Human Ca2+/calmodulin-dependent phosphodiesterase PDE1 is activated by the binding of calmodulin in the presence of Ca(2+). PDE1 has three subtypes PDE1A, PDE1B and PDE1C and their role is to hydrolyze both cGMP and cAMP. Their role is to antagonize the increased concentration of the intracellular second messengers determined by the synthetic activity of the adenylate cyclase enzymes thus governing intracellular cAMP dynamics in response to changes in the cytosolic Ca2+ concentration. PDE1 are mainly cytosolic but different isoforms are expressed in different tissues.

Literature References
PubMed ID Title Journal Year
10442095 Calmodulin-dependent cyclic nucleotide phosphodiesterase (PDE1)

Kakkar, R, Raju, RV, Sharma, RK

Cell Mol Life Sci 1999
16786160 Regulation of calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1): review

Sharma, RK, Das, SB, Lakshmikuttyamma, A, Selvakumar, P, Shrivastav, A

Int J Mol Med 2006
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Orthologous Events
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