guanine + (deoxy)ribose 1-phosphate <=> (deoxy)guanosine + orthophosphate (NP)

Stable Identifier
R-HSA-112034
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic nucleoside phosphorylase (NP) trimer catalyzes the reversible reaction of guanine with ribose 1-phosphate or deoxyribose 1-phosphate to form guanosine or deoxyguanosine and orthophosphate (Ealick et al. 1990; Wiginton et al. 1980). While NP is active with either ribose 1-phosphate or deoxyribose 1-phosphate in vitro, levels of deoxyribose 1-phosphate are normally low in vivo, limiting the extent of this reaction. NP deficiency in vivo is associated with defects in purine nucleotide salvage and leads to immunodeficiency (Williams et al. 1987).

Literature References
PubMed ID Title Journal Year
6771276 Characterization of purine nucleoside phosphorylase from human granulocytes and its metabolism of deoxyribonucleosides

Wiginton, DA, Coleman, MS, Hutton, JJ

J Biol Chem 1980
3029074 A human purine nucleoside phosphorylase deficiency caused by a single base change

Williams, SR, Gekeler, V, McIvor, RS, Martin, Jr, DW

J Biol Chem 1987
2104852 Three-dimensional structure of human erythrocytic purine nucleoside phosphorylase at 3.2 A resolution

Ealick, SE, Rule, SA, Carter, DC, Greenhough, TJ, Babu, YS, Cook, WJ, Habash, J, Helliwell, JR, Stoeckler, JD, Parks, Jr, RE, Chen, SF, Bugg, CE

J Biol Chem 1990
Participants
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Event Information
Catalyst Activity
Catalyst Activity
Title
purine-nucleoside phosphorylase activity of NP trimer [cytosol]
Physical Entity
Activity
Orthologous Events
Created