PLC beta mediated events

Stable Identifier
R-HSA-112043
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The phospholipase C (PLC) family of enzymes is both diverse and complex. The isoforms beta, gamma and delta (each have subtypes) make up the members of this family. PLC hydrolyzes phosphatidylinositol bisphosphate (PIP2) into two second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 mobilizes intracellular calcium stores while DAG activates protein kinase C isoforms which are involved in regulatory functions.

Literature References
PubMed ID Title Journal Year
16183910 Mammalian G proteins and their cell type specific functions

Wettschureck, N, Offermanns, S

Physiol Rev 2005
9218123 G proteins and opioid receptor-mediated signalling

Standifer, KM, Pasternak, GW

Cell Signal 1997
1335363 Receptor-to-effector signaling through G proteins: roles for beta gamma dimers as well as alpha subunits

Birnbaumer, L

Cell 1992
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database
Authored
Reviewed