ALKBH2 mediated reversal of alkylation damage

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R-HSA-112122
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Pathway
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Homo sapiens
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AlkB is an E.coli alpha-ketoglutarate- and Fe(II)-dependent dioxygenase that oxidizes the relevant methyl groups and releases them as formaldehyde. Two human homologs of AlkB, ALKBH2 and ALKBH3, both remove 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) from methylated polynucleotides in an alpha-ketoglutarate-dependent reaction. They act by direct damage reversal with the regeneration of the unsubstituted bases. E.coli AlkB and human ALKBH2 and ALKBH3 can also repair 1-ethyladenine (1-etA) residues in DNA with the release of acetaldehyde (Duncan et al., 2002, Lee et al. 2005).

Literature References
PubMed ID Title Journal Year
16174769 Repair of methylation damage in DNA and RNA by mammalian AlkB homologues

Lee, DH, Jin, SG, Cai, S, Chen, Y, Pfeifer, GP, O'Connor, TR

J Biol Chem 2005
15040447 Repairing DNA-methylation damage.

Sedgwick, B

Nat Rev Mol Cell Biol 2004
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