ALKBH3, a homolog of E.coli AlkB (Trewick et al. 2002), removes the ethyl group from 1-ethyladenine (1-etA) in a reaction dependent on alpha-ketoglutarate, oxygen and Fe2+. ALKBH3 directly reverses alkylating damage of DNA in the form of 1-etA, releasing acetaldehyde (Duncan et al. 2002). The reversal of alkylating damage of dsDNA by ALKBH3 requires the presence of DNA helicase ASCC3, a component of the activating signal co-activator complex (Dango et al. 2011). ALKBH3 can also repair methylated RNA (Aas et al. 2003).
Duncan, T, Trewick, SC, Koivisto, P, Bates, PA, Lindahl, T, Sedgwick, B
dioxygenase activity of ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3:1-etA-dsDNA [nucleoplasm]
© 2021 Reactome
