Reactome: A Curated Pathway Database

thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP]

Stable Identifier
R-HSA-112266
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Cytosolic thymidine phosphorylase (TYMP) catalyzes the reversible reactions of thymine or uracil with 2-deoxy-D-ribose 1-phosphate to form thymidine or deoxyuridine and orthiophosphate. The active form of the enzyme is a homodimer (Desgranges et al. 1981; Norman et al. 2004; Usuki et al. 1992).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
transferase activity, transferring pentosyl groups of TYMP dimer [cytosol] TYMP dimer [cytosol] transferase activity, transferring pentosyl groups (0016763)
Orthologous Events