thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP]

Stable Identifier
R-HSA-112266
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Cytosolic thymidine phosphorylase (TYMP) catalyzes the reversible reactions of thymine or uracil with 2-deoxy-D-ribose 1-phosphate to form thymidine or deoxyuridine and orthiophosphate. The active form of the enzyme is a homodimer (Desgranges et al. 1981; Norman et al. 2004; Usuki et al. 1992).

Literature References
PubMed ID Title Journal Year
7284378 Catabolism of thymidine in human blood platelets: purification and properties of thymidine phosphorylase

Desgranges, C, Razaka, G, Rabaud, M, Bricaud, H

Biochim Biophys Acta 1981
1590793 Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity.

Usuki, K, Saras, J, Waltenberger, J, Miyazono, K, Pierce, G, Thomason, A, Heldin, CH

Biochem Biophys Res Commun 1992
14725767 Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor

Norman, RA, Barry, ST, Bate, M, Breed, J, Colls, JG, Ernill, RJ, Luke, RW, Minshull, CA, McAlister, MS, McCall, EJ, McMiken, HH, Paterson, DS, Timms, D, Tucker, JA, Pauptit, RA

Structure 2004
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
transferase activity, transferring pentosyl groups of TYMP dimer [cytosol]
Physical Entity
Activity
Orthologous Events