The receptor:G-protein complex dissociates

Stable Identifier
R-HSA-112271
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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The ternary complex neurotransmitter:receptor:G-protein dissociates. Both the alpha-i subunit and beta:gamma complex become active, by conformational transition and surface exposure, and both are free to activate downstream effectors.

Literature References
PubMed ID Title Journal Year
8208289 Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein.

Lambright, DG, Noel, JP, Hamm, HE, Sigler, PB

Nature 1994
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