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Formation of RNA Pol II elongation complex
Stable Identifier
R-HSA-112382
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Transcription Elongation (Homo sapiens)
Formation of RNA Pol II elongation complex (Homo sapiens)
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TFIIS is a transcription factor involved in different phases of transcription, occurring in a major ubiquitous form and other tissue specific forms. TFIIS stimulates RNA Pol II complex out of elongation arrest.
Other transcription factors like ELL, Elongin family members and TFIIF interact directly with elongating Pol II and increase its elongation rate. These factors have been observed to act on naked DNA templates by suppressing transient pausing by the enzyme at all or most steps of nucleotide addition. In Drosophila, ELL is found at a large number of transcriptionally active sites on polytene chromosomes. In general, ELL is suspected to have more unidentified functions.
Elongin is a heterotrimeric protein complex that stimulates the overall rate of elongation. In addition, Elongin may act as an E3 Ubiquitin ligase. Ubiquitylation of RNA Pol II occurs rapidly after genotoxic assault by UV light or chemicals, and results in degradation by proteasome. The FACT complex appears to promote elongation by facilitating passage of polymerase through chromatin.
All these factors contribute to the formation of a processive elongation complex centered around the RNA Pol II complex positioned on the DNA:RNA hybrid. This enables the RNA Pol II elongation complex to function as a platform that coordinates mRNA processing and export (Reviewed by Shilatifard et al., 2003).
Literature References
PubMed ID
Title
Journal
Year
12676794
The RNA polymerase II elongation complex.
Conaway, JW
,
Shilatifard, A
,
Conaway, RC
Annu Rev Biochem
2003
Participants
Events
Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex
(Homo sapiens)
Recruitment of elongation factors to form elongation complex
(Homo sapiens)
Participates
as an event of
RNA Polymerase II Transcription Elongation (Homo sapiens)
Event Information
Go Biological Process
transcription elongation from RNA polymerase II promoter (0006368)
Orthologous Events
Formation of HIV-1 elongation complex containing HIV-1 Tat (Homo sapiens)
Formation of RNA Pol II elongation complex (Bos taurus)
Formation of RNA Pol II elongation complex (Caenorhabditis elegans)
Formation of RNA Pol II elongation complex (Canis familiaris)
Formation of RNA Pol II elongation complex (Drosophila melanogaster)
Formation of RNA Pol II elongation complex (Gallus gallus)
Formation of RNA Pol II elongation complex (Mus musculus)
Formation of RNA Pol II elongation complex (Rattus norvegicus)
Formation of RNA Pol II elongation complex (Sus scrofa)
Formation of RNA Pol II elongation complex (Xenopus tropicalis)
Formation of HIV elongation complex in the absence of HIV Tat (Homo sapiens)
Authored
Gopinathrao, G (2004-06-22)
Created
Conaway, JW (2003-09-11)
Conaway, RC (2003-09-11)
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