Resumption of elongation after recovery from pausing

Stable Identifier
R-HSA-112392
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Recovery from pausing occurs spontaneously after a variable length of time as the enzyme spontaneously slides forward again. This renders the transcript's 3'-OH terminus realigned with the catalytic Mg2+ site of the enzyme. TFIIS is capable of excising the nascent transcript at 2 or 3 nucleotides upstream of the transcript's 3'-end to reinitiate processive elongation (reviewed by Shilatifard et al., 2003).

Literature References
PubMed ID Title Journal Year
12676794 The RNA polymerase II elongation complex.

Shilatifard, A, Conaway, RC, Conaway, JW

Annu Rev Biochem 2003
Participants
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Orthologous Events
Authored
Created