SUPT16H [nucleoplasm]

Stable Identifier
R-HSA-112415
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
FACT 140 kDa subunit
Locations in the PathwayBrowser for interactor UniProt:Q99459 CDC5L
General

DSIF is a heterodimer consisting of hSPT4 (human homolog of yeast Spt4- p14) and hSPT5 (human homolog of yeast Spt5-p160). DSIF association with Pol II may be enabled by Spt5 binding to Pol II creating a scaffold for NELF binding (Wada et al.,1998). Spt5 subunit of DSIF can be phosphorylated by P-TEFb.

External Reference Information
External Reference
Gene Names
SUPT16H, FACT140, FACTP140
Chain
initiator methionine:1, chain:2-1047
Reference Transcript
Other Identifiers
0006520037
11198
11717114_a_at
16790267
217815_at
233827_s_at
3446084
3446086
3446094
3446097
3446099
3446101
3446103
3446107
3446108
3446109
3556324
3556325
3556326
3556327
3556329
3556330
3556331
3556333
3556334
3556336
3556337
3556338
3556339
3556340
3556341
3556342
3556343
3556344
3556345
3556346
3556347
3556348
3556349
3556350
3556352
3556353
3556354
3556356
3556358
3556364
3556365
3556366
57040_at
68143_at
7977674
90470_r_at
A_23_P151634
A_24_P153800
GE58441
GO:0003674
GO:0003723
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0006259
GO:0006260
GO:0006281
GO:0006337
GO:0006366
GO:0006368
GO:0006950
GO:0006974
GO:0007165
GO:0008150
GO:0009058
GO:0016032
GO:0031491
GO:0032786
GO:0032968
GO:0032991
GO:0034641
GO:0034724
GO:0035101
GO:0042393
GO:0043226
GO:0044403
GO:0051276
GO:1901796
Hs.14963.1.S1_3p_a_at
ILMN_1781516
TC14000916.hg
g6005756_3p_at
Participant Of
Inferred To
Cross References
RefSeq
OpenTargets
GeneCards
PRO
PDB
Interactors (7)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q08945 SSRP1  1 0.809 6
 UniProt:P33991 MCM4  1 0.602 3
 UniProt:P68431 H3C1  59 0.597 3
 UniProt:Q99459 CDC5L  1 0.547 2
 UniProt:Q9UGP5 POLL  1 0.508 2
 UniProt:Q9UPN9 TRIM33  1 0.462 3
 UniProt:P50750 CDK9  1 0.462 3
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