Reactome | TCEB1 [nucleoplasm]

TCEB1 [nucleoplasm]

Stable Identifier

R-HSA-112422

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Elongin B protein, Transcription elongation factor B polypeptide 1, RNA polymerase II transcription factor SIII subunit C, SIII p15, Elongin C, EloC, Elongin 15 kDa subunit

Locations in the PathwayBrowser for interactor UniProt:Q15370 ELOB

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External Reference Information

External Reference

UniProt:Q15369 ELOC

Gene Names

ELOC, TCEB1

Chain

chain:1-112

Reference Genes

BioGPS Gene:6921 ELOC

COSMIC (genes):ELOC ELOC

CTD Gene:6921 ELOC

dbSNP Gene:6921 ELOC

ENSEMBL:ENSG00000154582 ELOC

HGNC:11617 ELOC

KEGG:hsa:6921 ELOC

Monarch:6921 ELOC

NCBI Gene:6921 ELOC

OMIM:600788 ELOC

UCSC:Q15369 ELOC

Reference Transcript

Participates

as an input of

Formation of Elongin BC complex (Homo sapiens)

as a component of

Other forms of this molecule

ELOC [cytosol]

Inferred To

EloC [nucleoplasm] (Drosophila melanogaster)

Eloc [nucleoplasm] (Mus musculus)

Eloc [nucleoplasm] (Rattus norvegicus)

eloca [nucleoplasm] (Danio rerio)

TCEB1 [nucleoplasm] (Gallus gallus)

TCEB1 [nucleoplasm] (Sus scrofa)

tceb1 [nucleoplasm] (Dictyostelium discoideum)

eloc [nucleoplasm] (Xenopus tropicalis)

ELC1 [nucleoplasm] (Saccharomyces cerevisiae)

ELOC [nucleoplasm] (Bos taurus)

ELOC [nucleoplasm] (Canis familiaris)

elc1 [nucleoplasm] (Schizosaccharomyces pombe)

elc-1 [nucleoplasm] (Caenorhabditis elegans)

Cross References

OpenTargets

ENSG00000154582

ENSEMBL

ENST00000520242, ENST00000284811, ENSG00000154582, ENST00000687224, ENSP00000509989, ENSP00000428074, ENSP00000428171, ENSP00000284811, ENSP00000430224, ENSP00000509184, ENST00000518127, ENSP00000478121, ENST00000523815, ENST00000522337, ENST00000688584, ENSP00000429906, ENST00000520210, ENST00000622804, ENSP00000428334

GeneCards

ELOC

HPA

ENSG00000154582-ELOC

PRO

Q15369

Pharos - Targets

Q15369

GlyGen

Q15369

PDB

6ZHC, 6I5N, 9EQJ, 8OEW, 8JE1, 4BKT, 8EBN, 7Z76, 8WQG, 7ZLM, 8EWV, 5BO4, 8BDM, 8G1P, 7ZNT, 6GMR, 4W9J, 4N9F, 8BB4, 5NW1, 8FY1, 8BEB, 7KHH, 5NVW, 5NW2, 8JAQ, 6FMI, 6GFY, 7PLO, 2IZV, 8PQL, 4BKS, 4WQO, 8OL1, 5T35, 8VLB, 6R7F, 6C5X, 8QW7, 8BDX, 8JAV, 4W9D, 9BOL, 8OF0, 6R7N, 7UPN, 8QJS, 8WQA, 2MA9, 8WQH, 7ZLR, 7ZLP, 2C9W, 8CX1, 8BDT, 8CX2, 4W9H, 5NVZ, 8FY2, 3ZTC, 8G1Q, 8FVJ, 8CQE, 4B95, 4W9F, 5NW0, 8WQC, 7CJB, 8BB5, 6FMK, 6BVB, 3DCG, 8PC2, 8JAS, 4W9K, 6I4X, 8R5H, 6SIS, 6GFX, 8SH2, 8BDO, 6R7H, 4W9E, 4AJY, 9EQM, 7M6T, 5N4W, 8Q7R, 6I5J, 8QU8, 8EI3, 8OEV, 8BB2, 3ZKJ, 8CX0, 7ZLO, 7JTO, 3ZRC, 7Z6L, 1LM8, 8SZK, 5NVY, 8BDJ, 6V9H, 9BJU, 8FY0, 8QVU, 7S4E, 1VCB, 7Z77, 6GMN, 5NVV, 8IJ1, 8P0F, 6HAX, 8WQB, 8BDL, 8CQK, 6HR2, 8C13, 7Q2J, 4W9C, 4W9L, 8OKX, 8JAR, 7PI4, 6GFZ, 6I7R, 8JE2, 4B9K, 6P59, 7JTP, 4AWJ, 8QJR, 8WQF, 7ZLS, 7ZLN, 6GMX, 8BDS, 3ZRF, 4W9I, 3ZTD, 8VL9, 3ZUN, 8FVI, 8BB3, 1LQB, 6HAY, 8WQE, 5NVX, 6GMQ, 4W9G, 6FMJ, 5LLI, 8JAL, 8CQL, 8JAU, 8BDN, 8QW6, 8BDI, 3ZNG

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15370 ELOB	2	ELOB [cytosol] (R-HSA-180551) TCEB2 [nucleoplasm] (R-HSA-112423)	0.952	20
UniProt:P40337 VHL	3	VHL [cytosol] (R-HSA-391423) VHL [nucleoplasm] (R-HSA-1234127) monoSUMO1-K159,171,196-VHL [nucleoplasm] (R-HSA-4551697)	0.871	10
UniProt:Q13617 CUL2	3	CUL2 [cytosol] (R-HSA-416982) CUL2 [nucleoplasm] (R-HSA-1234126) G76-NEDD8-K689-CUL2 [cytosol] (R-HSA-8952511)	0.802	10
UniProt:Q5VZV1 MT21C			0.781	9
UniProt:P78395 PRAME			0.742	12
UniProt:A0A663DJA2 ORF10			0.738	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.725	12
UniProt:Q16665 HIF1A	7	HIF1A [nucleoplasm] (R-HSA-1234135) HIF1A [cytosol] (R-HSA-1234102) p-Y565-HIF1A [cytosol] (R-HSA-8857584) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) HN-HIF1A [cytosol] (R-HSA-1234110) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) 2xHP-HIF1A [cytosol] (R-HSA-1234131)	0.702	5
UniProt:O15524 SOCS1	1	SOCS1 [cytosol] (R-HSA-204910)	0.678	4
UniProt:Q99619 SPSB2	1	SPSB2 [cytosol] (R-HSA-976048)	0.669	4
UniProt:Q96A44 SPSB4	1	SPSB4 [cytosol] (R-HSA-976023)	0.669	3
UniProt:Q96DX5 ASB9	1	ASB9 [cytosol] (R-HSA-975424)	0.659	5
UniProt:Q93034 CUL5	2	CUL5 [cytosol] (R-HSA-180528) G76-NEDD8-K724-CUL5 [cytosol] (R-HSA-8952014)	0.643	6
UniProt:Q9NWX5 ASB6	1	ASB6 [cytosol] (R-HSA-975412)	0.643	5
UniProt:Q9UHY1 NRBP1	1	NRBP1 [nucleoplasm] (R-HSA-376332)	0.643	4
UniProt:Q96S21 RAB40C	2	GGC-RAB40C [cytosol] (R-HSA-8874025) RAB40C [cytosol] (R-HSA-8873693)	0.642	4
UniProt:O14508 SOCS2	1	SOCS2 [cytosol] (R-HSA-1169204)	0.573	2
UniProt:Q8N668 COMMD1	2	COMMD1 [nucleoplasm] (R-HSA-8955094) COMMD1 [cytosol] (R-HSA-8955110)	0.564	2
UniProt:P12504 VIF			0.558	5
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q96G25 MED8	1	MED8 [nucleoplasm] (R-HSA-556784)	0.548	3
UniProt:Q9H765 ASB8	1	ASB8 [cytosol] (R-HSA-975422)	0.547	2
UniProt:P40337-3 VHL			0.547	2
UniProt:Q13618 CUL3	3	CUL3 [cytosol] (R-HSA-975979) CUL3 [nucleoplasm] (R-HSA-5635033) G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516)	0.547	3
UniProt:O14543 SOCS3	1	SOCS3 [cytosol] (R-HSA-873794)	0.527	3
UniProt:Q7L5N1 COPS6	2	COPS6 [nucleoplasm] (R-HSA-5697026) COPS6 [cytosol] (R-HSA-416961)	0.527	5
UniProt:Q9BQ90 KLHDC3	1	KLHDC3 [cytosol] (R-HSA-535552)	0.527	3
UniProt:Q8WXH6 RAB40A	2	GGC-RAB40A [cytosol] (R-HSA-8874021) RAB40A [cytosol] (R-HSA-8873694)	0.527	2
UniProt:Q9Y2U9 KLDC2			0.527	2
UniProt:Q12829 RAB40B	2	GGC-RAB40B [cytosol] (R-HSA-8874024) RAB40B [cytosol] (R-HSA-8873718)	0.527	4

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