2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing

Stable Identifier
R-HSA-113411
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Pol II pausing is believed to result from reversible backtracking of the Pol II enzyme complex by ~2 to 4 nucleotides. This leads to misaligned 3'-OH terminus that is unable to be an acceptor for the incoming NTPs in synthesis of next phosphodiester bond (reviewed by Shilatifard et al., 2003).

Literature References
PubMed ID Title Journal Year
12676794 The RNA polymerase II elongation complex.

Shilatifard, A, Conaway, RC, Conaway, JW

Annu Rev Biochem 2003
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