TFIIS-mediated recovery of elongation from arrest

Stable Identifier
R-HSA-113413
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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TFIIS reactivates arrested RNA Pol II directly interacting with the enzyme resulting in endonucleolytic excision of nascent transcript ~7-14 nucleotides upstream of the 3' end. This reaction is catalyzed by the catalytic site and results in the generation of a new 3'-OH terminus that could be used for re-extension from the correctly base paired site (reviewed by Shilatifard et al., 2003).

Literature References
PubMed ID Title Journal Year
12676794 The RNA polymerase II elongation complex.

Shilatifard, A, Conaway, RC, Conaway, JW

Annu Rev Biochem 2003
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