Inhibition of replication initiation of damaged DNA by RB1/E2F1

Stable Identifier
R-HSA-113501
Type
Pathway
Species
Homo sapiens
Compartment
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Summation

During S phase of the cell cycle, RB1 is dephosphorylated by the PP2A protein phosphatase complex. Unphosphorylated RB1 associates with DNA damage sites in S phase, preventing initiation of DNA replication from these sites (Knudsen et al. 2000, Avni et al. 2003).

Literature References
PubMed ID Title Journal Year
17991896 Protein phosphatase 2A subunit PR70 interacts with pRb and mediates its dephosphorylation

Magenta, A, Fasanaro, P, Romani, S, Di Stefano, V, Capogrossi, MC, Martelli, F

Mol Cell Biol 2008
14527418 Active localization of the retinoblastoma protein in chromatin and its response to S phase DNA damage.

Avni, D, Yang, H, Martelli, F, Hofmann, F, ElShamy, WM, Ganesan, S, Scully, R, Livingston, DM

Mol Cell 2003
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Created