Inhibition of replication initiation of damaged DNA by RB1/E2F1

Stable Identifier
R-HSA-113501
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

During S phase of the cell cycle, RB1 is dephosphorylated by the PP2A protein phosphatase complex. Unphosphorylated RB1 associates with DNA damage sites in S phase, preventing initiation of DNA replication from these sites (Knudsen et al. 2000, Avni et al. 2003).

Participants
Participant Of
Orthologous Events