E2F-enabled inhibition of pre-replication complex formation

Stable Identifier
R-HSA-113507
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Under specific conditions, Cyclin B, a mitotic cyclin, can inhibit the functions of pre-replicative complex. E2F1 activates Cdc25A protein which regulates Cyclin B in a positive manner. Cyclin B/Cdk1 function is restored which leads to the disruption of pre-replicative complex. This phenomenon has been demonstrated by Bosco et al (2001) in Drosophila.

Literature References
PubMed ID Title Journal Year
11090133 Nuclear organization of DNA replication in primary mammalian cells

Kennedy, BK, Barbie, DA, Classon, M, Harlow, E, Dyson, NJ

Genes Dev 2000
Participants
Participant Of
Authored