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Go!
GMNN [nucleoplasm]
Stable Identifier
R-HSA-113554
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
geminin
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
CDT1 binds geminin (Homo sapiens)
CDT1:GMNN [nucleoplasm] (Homo sapiens)
GMNN [nucleoplasm] (Homo sapiens)
GMNN [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
CDT1 binds geminin (Homo sapiens)
CDT1:GMNN [nucleoplasm] (Homo sapiens)
GMNN [nucleoplasm] (Homo sapiens)
GMNN [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
CDT1 binds geminin (Homo sapiens)
CDT1:GMNN [nucleoplasm] (Homo sapiens)
GMNN [nucleoplasm] (Homo sapiens)
GMNN [nucleoplasm] (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Homo sapiens)
CDT1:GMNN [nucleoplasm] (Homo sapiens)
GMNN [nucleoplasm] (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
CDT1 binds geminin (Homo sapiens)
CDT1:GMNN [nucleoplasm] (Homo sapiens)
GMNN [nucleoplasm] (Homo sapiens)
GMNN [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75496 GMNN
Gene Names
GMNN
Chain
chain:1-209
Reference Genes
BioGPS Gene:51053 GMNN
COSMIC (genes):GMNN GMNN
CTD Gene:51053 GMNN
dbSNP Gene:51053 GMNN
ENSEMBL:ENSG00000112312 GMNN
HGNC:17493 GMNN
KEGG:hsa:51053 GMNN
Monarch:51053 GMNN
NCBI Gene:51053 GMNN
OMIM:602842 GMNN
UCSC:O75496 GMNN
Reference Transcript
RefSeq:NM_001251990.1 GMNN
RefSeq:NM_001251989.1 GMNN
RefSeq:XM_005249159.1 GMNN
RefSeq:NM_015895.4 GMNN
RefSeq:NM_001251991.1 GMNN
Other Identifiers
11754937_a_at
17005396
218350_PM_s_at
218350_s_at
2898603
2898604
2898605
2898606
2898607
2898608
2898609
2898610
2898611
2898612
2898614
2898615
2898617
2898618
2898619
2898622
2898623
2898624
2898625
2898626
2898627
2898628
49176_at
51053
53205_at
8117225
A_14_P139511
A_23_P19712
GE79328
GO:0003682
GO:0003714
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006275
GO:0006355
GO:0007346
GO:0008156
GO:0009887
GO:0017053
GO:0030174
GO:0035563
GO:0042826
GO:0043226
GO:0045786
GO:0045892
GO:0060090
GO:0065003
GO:0071163
GO:0140110
GO:0140297
GO:2000104
HMNXSV003001107
ILMN_1720114
PH_hs_0012808
TC06000149.hg
g7705681_3p_a_at
Participates
as a component of
CDT1:GMNN [nucleoplasm] (Homo sapiens)
as an input of
CDT1 binds geminin (Homo sapiens)
Other forms of this molecule
PolyUb-GMNN [nucleoplasm]
Inferred To
GMNN [nucleoplasm]
(Bos taurus)
GMNN [nucleoplasm]
(Canis familiaris)
GMNN [nucleoplasm]
(Gallus gallus)
GMNN [nucleoplasm]
(Sus scrofa)
gmnn [nucleoplasm]
(Xenopus tropicalis)
Gmnn [nucleoplasm]
(Mus musculus)
Gmnn [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_056979.1
,
NP_001238920.1
,
NP_001238919.1
,
NP_001238918.1
,
XP_005249216.1
OpenTargets
ENSG00000112312
ENSEMBL
ENST00000230056
,
ENSP00000477506
,
ENSP00000348902
,
ENST00000356509
,
ENSP00000230056
,
ENST00000620958
HPA
ENSG00000112312-GMNN
PRO
O75496
Pharos - Targets
O75496
GlyGen
O75496
Orphanet
GMNN
PDB
2LP0
,
7KLZ
,
4BRY
,
2WVR
,
1UII
,
1T6F
Interactors (38)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H211 CDT1
1
CDT1 [nucleoplasm]
(R-HSA-68536)
0.975
22
UniProt:Q8NDP4 ZNF439
1
ZNF439 [nucleoplasm]
(R-HSA-1247524)
0.781
7
UniProt:D6RGH6 MCIN
0.768
9
UniProt:Q8IYE0 CC146
0.743
5
UniProt:Q8IYE0-2 CCDC146
0.666
4
UniProt:Q14186 TFDP1
1
TFDP1 [nucleoplasm]
(R-HSA-68652)
0.643
3
UniProt:P20248 CCNA2
3
CCNA2 [nucleoplasm]
(R-HSA-68905)
CCNA2 [cytosol]
(R-HSA-157444)
PolyUb-CCNA2 [nucleoplasm]
(R-HSA-6783099)
0.643
5
UniProt:P24941 CDK2
5
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
CDK2 [nucleoplasm]
(R-HSA-68365)
CDK2 [cytosol]
(R-HSA-157440)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
0.643
4
UniProt:P31274 HXC9
0.618
3
UniProt:P42771 CDKN2A
20
p16INK4A D84G [cytosol]
(R-HSA-9632461)
p16INK4A E88* [cytosol]
(R-HSA-9632588)
p16INK4A R87P [cytosol]
(R-HSA-9632335)
p16INK4A V126D [cytosol]
(R-HSA-9631055)
p16INK4A W110* [cytosol]
(R-HSA-9632585)
p16INK4A D84H [cytosol]
(R-HSA-9632489)
p16INK4A R80* [cytosol]
(R-HSA-9632586)
p16INK4A P114L [cytosol]
(R-HSA-9630916)
p16INK4A R58* [cytosol]
(R-HSA-9632582)
p16INK4A D84N [cytosol]
(R-HSA-9632483)
p16INK4A M53I [cytosol]
(R-HSA-9630911)
p16INK4A D84Y [cytosol]
(R-HSA-9632478)
p16INK4A G101W [cytosol]
(R-HSA-9631257)
p16INK4A P81L [cytosol]
(R-HSA-9632280)
p16INK4A A20P [cytosol]
(R-HSA-9630805)
p16INK4A D84V [cytosol]
(R-HSA-9632465)
p16INK4A P81T [cytosol]
(R-HSA-9632275)
p16INK4A P81H [cytosol]
(R-HSA-9632293)
p16INK4A D84A [cytosol]
(R-HSA-9632486)
p16INK4A P81R [cytosol]
(R-HSA-9632294)
0.592
2
UniProt:Q9BZE0 GLIS2
0.556
3
UniProt:P15622-3 ZNF250
0.556
3
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.556
3
UniProt:Q86UD0 SAPC2
0.556
3
UniProt:Q63ZY3 KANK2
0.556
3
UniProt:Q06124-2 PTPN11
0.556
3
UniProt:P06493 CDK1
11
p-T161-CDK1 [nucleoplasm]
(R-HSA-170066)
p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-HSA-170074)
p-T161-CDK1 [cytosol]
(R-HSA-157415)
p-T14,Y15,T161-CDK1 [cytosol]
(R-HSA-170071)
CDK1 [cytosol]
(R-HSA-170075)
CDK1 [nucleoplasm]
(R-HSA-68889)
p-T14-CDK1 [cytosol]
(R-HSA-170064)
p-T14-CDK1 [nucleoplasm]
(R-HSA-170045)
p-T14,T161-CDK1 [nucleoplasm]
(R-HSA-170078)
p-Y4-CDK1 [cytosol]
(R-HSA-9836187)
CDK1 [endoplasmic reticulum membrane]
(R-HSA-264424)
0.527
2
UniProt:Q9H668 STN1
1
STN1 [nucleoplasm]
(R-HSA-9668821)
0.527
2
UniProt:Q13309 SKP2
3
SKP2 [nucleoplasm]
(R-HSA-975554)
PolyUb-SKP2 [nucleoplasm]
(R-HSA-9687073)
SKP2 [cytosol]
(R-HSA-975495)
0.527
2
UniProt:Q9NQX4 MYO5C
0.527
2
UniProt:P29597 TYK2
5
p-Y1054-TYK2 [cytosol]
(R-HSA-1112598)
p-Y1054,Y1055-TYK2 [cytosol]
(R-HSA-909682)
TYK2 [cytosol]
(R-HSA-877348)
p-Y-TYK2 [cytosol]
(R-HSA-6784366)
p-TYK2 [cytosol]
(R-HSA-8950424)
0.527
2
UniProt:P33552 CKS2
0.527
2
UniProt:P11142 HSPA8
10
HSPA8 [cytosol]
(R-HSA-264476)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
0.527
2
UniProt:Q13395 TARB1
0.527
2
UniProt:P61024 CKS1B
1
CKS1B [nucleoplasm]
(R-HSA-187533)
0.527
2
UniProt:Q2NKJ3 CTC1
1
CTC1 [nucleoplasm]
(R-HSA-9668825)
0.527
2
UniProt:Q9ULT8 HECTD1
1
HECTD1 [cytosol]
(R-HSA-5688966)
0.527
2
UniProt:Q8TCT0 CERK
1
CERK [plasma membrane]
(R-HSA-1631584)
0.527
2
UniProt:Q2NKX9 CB068
0.527
2
UniProt:A0JP26 POTB3
0.527
2
UniProt:Q13613 MTMR1
1
MTMR1 [cytosol]
(R-HSA-1604647)
0.527
2
UniProt:O15344 MID1
1
MID1 [cytosol]
(R-HSA-976027)
0.527
2
UniProt:O95429 BAG4
3
BAG4 [cytosol]
(R-HSA-5212670)
BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane]
(R-HSA-8853156)
BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane]
(R-HSA-8853157)
0.527
2
UniProt:Q53GT1 KLHL22
1
KLHL22 [cytosol]
(R-HSA-8863210)
0.527
2
UniProt:Q8IUE0 TF2LY
0.527
2
UniProt:Q68DK7 MSL1
1
MSL1 [nucleoplasm]
(R-HSA-3321894)
0.527
2
UniProt:Q16254 E2F4
1
E2F4 [nucleoplasm]
(R-HSA-68664)
0.527
2
UniProt:Q00526 CDK3
0.527
3
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