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CDC6 [cytosol]
Stable Identifier
R-HSA-113566
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Cdc6
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
CDK-mediated phosphorylation and removal of Cdc6 (Homo sapiens)
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Homo sapiens)
ubiquitinated Cdc6 [cytosol] (Homo sapiens)
CDC6 [cytosol] (Homo sapiens)
Ubiquitinated Cdc6 is degraded by the proteasome (Homo sapiens)
ubiquitinated Cdc6 [cytosol] (Homo sapiens)
CDC6 [cytosol] (Homo sapiens)
DNA Replication (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
CDK-mediated phosphorylation and removal of Cdc6 (Homo sapiens)
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Homo sapiens)
ubiquitinated Cdc6 [cytosol] (Homo sapiens)
CDC6 [cytosol] (Homo sapiens)
Ubiquitinated Cdc6 is degraded by the proteasome (Homo sapiens)
ubiquitinated Cdc6 [cytosol] (Homo sapiens)
CDC6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99741 CDC6
Gene Names
CDC6, CDC18L
Chain
chain:1-560
Reference Genes
BioGPS Gene:990 CDC6
COSMIC (genes):CDC6 CDC6
CTD Gene:990 CDC6
dbSNP Gene:990 CDC6
ENSEMBL:ENSG00000094804 CDC6
ENSEMBL_homo_sapiens_GENE:ENSG00000094804.12 CDC6
HGNC:1744 CDC6
KEGG Gene (Homo sapiens):990 CDC6
Monarch:990 CDC6
NCBI Gene:990 CDC6
OMIM:602627 CDC6
UCSC:Q99741 CDC6
Reference Transcript
RefSeq:NM_001254.3 CDC6
Other Identifiers
11743064_at
11743065_at
1536_at
16834056
203967_PM_at
203967_at
203968_PM_s_at
203968_s_at
36839_at
3720897
3720900
3720901
3720902
3720903
3720904
3720905
3720906
3720907
3720910
3720913
3720914
3720916
3720917
3720918
3720920
8007071
990
A_14_P127674
A_23_P49972
A_33_P3218450
GE59420
GO:0000076
GO:0000079
GO:0000166
GO:0000278
GO:0000910
GO:0000922
GO:0003824
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005856
GO:0006260
GO:0006270
GO:0007049
GO:0007059
GO:0007089
GO:0008156
GO:0008285
GO:0016787
GO:0016887
GO:0019900
GO:0023052
GO:0030071
GO:0032467
GO:0033314
GO:0036211
GO:0043226
GO:0045171
GO:0048146
GO:0051233
GO:0051301
GO:0051984
GO:0072686
GO:0140657
GO:1904117
GO:1904385
HMNXSV003051890
ILMN_1785914
PH_hs_0033144
TC17000495.hg
U77949_at
g4502702_3p_a_at
p7354
Participates
as a component of
ubiquitinated Cdc6 [cytosol] (Homo sapiens)
Other forms of this molecule
CDC6 [nucleoplasm]
p-CDC6 [nucleoplasm]
p-CDC6 [cytosol]
Inferred To
cdc-6 [cytosol]
(Caenorhabditis elegans)
Cdc6 [cytosol]
(Drosophila melanogaster)
Cdc6 [cytosol]
(Rattus norvegicus)
CDC6 [cytosol]
(Bos taurus)
CDC6 [cytosol]
(Canis familiaris)
CDC6 [cytosol]
(Dictyostelium discoideum)
CDC6 [cytosol]
(Gallus gallus)
CDC6 [cytosol]
(Mus musculus)
CDC6 [cytosol]
(Plasmodium falciparum)
CDC6 [cytosol]
(Saccharomyces cerevisiae)
CDC6 [cytosol]
(Schizosaccharomyces pombe)
CDC6 [cytosol]
(Sus scrofa)
cdc6 [cytosol]
(Danio rerio)
cdc6 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001245.1
OpenTargets
ENSG00000094804
GeneCards
Q99741
HPA
ENSG00000094804-CDC6
Ensembl
ENST00000649662
,
ENSG00000094804
,
ENSP00000497345
,
ENSP00000209728
,
ENST00000209728
PRO
Q99741
Pharos - Targets
Q99741
Orphanet
19837
PDB
2CCI
,
4I5N
,
8HT7
,
2CCH
,
4I5L
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P53350 PLK1
4
PLK1 [nucleoplasm]
(R-HSA-156720)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
PLK1 [cytosol]
(R-HSA-164603)
0.632
6
UniProt:Q9H211 CDT1
1
CDT1 [nucleoplasm]
(R-HSA-68536)
0.609
3
UniProt:P38936 CDKN1A
5
p-T145-CDKN1A [cytosol]
(R-HSA-198614)
p-Y77-CDKN1A [cytosol]
(R-HSA-8942601)
CDKN1A [cytosol]
(R-HSA-182512)
CDKN1A [nucleoplasm]
(R-HSA-182585)
p-S130-CDKN1A [nucleoplasm]
(R-HSA-187857)
0.571
2
UniProt:P28908 TNFRSF8
1
TNFRSF8 [plasma membrane]
(R-HSA-5668758)
0.527
2
UniProt:Q9UHF4 IL20RA
1
IL20RA [plasma membrane]
(R-HSA-448713)
0.527
2
UniProt:P37173 TGFBR2
9
TGFBR2 Y470D [plasma membrane]
(R-HSA-3640905)
TGFBR2 E526Q [plasma membrane]
(R-HSA-3645770)
TGFBR2 D522N [plasma membrane]
(R-HSA-3640907)
TGFBR2 R528H [plasma membrane]
(R-HSA-3640894)
TGFBR2 R528C [plasma membrane]
(R-HSA-3640899)
TGFBR2 K128Afs*3 [cytosol]
(R-HSA-3642173)
TGFBR2 K128Sfs*35 [cytosol]
(R-HSA-3642166)
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-HSA-4332222)
TGFBR2 [plasma membrane]
(R-HSA-170842)
0.527
2
UniProt:O14498 ISLR
2
ISLR [extracellular region]
(R-HSA-8848919)
ISLR [platelet alpha granule lumen]
(R-HSA-8848912)
0.527
2
UniProt:Q9H8J5 MANS1
0.527
2
UniProt:Q9Y5F2 PCDBB
0.527
2
UniProt:Q86XD5 FAM131B
2
FAM131B(1-18)-BRAF(381-766) fusion [cytosol]
(R-HSA-6802323)
FAM131B(1-18)-p-BRAF(381-766) fusion [cytosol]
(R-HSA-6802527)
0.527
2
UniProt:O60637 TSN3
0.527
2
UniProt:P06493 CDK1
11
CDK1 [endoplasmic reticulum membrane]
(R-HSA-264424)
p-Y4-CDK1 [cytosol]
(R-HSA-9836187)
p-T14,T161-CDK1 [nucleoplasm]
(R-HSA-170078)
p-T14-CDK1 [nucleoplasm]
(R-HSA-170045)
p-T14-CDK1 [cytosol]
(R-HSA-170064)
CDK1 [nucleoplasm]
(R-HSA-68889)
CDK1 [cytosol]
(R-HSA-170075)
p-T14,Y15,T161-CDK1 [cytosol]
(R-HSA-170071)
p-T161-CDK1 [cytosol]
(R-HSA-157415)
p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-HSA-170074)
p-T161-CDK1 [nucleoplasm]
(R-HSA-170066)
0.524
2
UniProt:O95801 TTC4
0.482
2
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