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CHEK2 [nucleoplasm]
Stable Identifier
R-HSA-113824
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Chk2, Serine/threonine-protein kinase Chk2 (EC 2.7.1.-) (Cds1), Serine/threonine-protein kinase Chk2 , Cds1
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G2/M Checkpoints (Homo sapiens)
G2/M DNA damage checkpoint (Homo sapiens)
CHEK2 is recruited to DNA DSBs (Homo sapiens)
CHEK2 [nucleoplasm] (Homo sapiens)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Homo sapiens)
CHEK2 [nucleoplasm] (Homo sapiens)
Phosphorylation and activation of CHEK2 by ATM (Homo sapiens)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Homo sapiens)
CHEK2 [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
DNA Double Strand Break Response (Homo sapiens)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
CHEK2 is recruited to DNA DSBs (Homo sapiens)
CHEK2 [nucleoplasm] (Homo sapiens)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Homo sapiens)
CHEK2 [nucleoplasm] (Homo sapiens)
Phosphorylation and activation of CHEK2 by ATM (Homo sapiens)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Homo sapiens)
CHEK2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O96017 CHEK2
Gene Names
CHEK2, CDS1, CHK2, RAD53
Chain
chain:1-543
Reference Genes
BioGPS Gene:11200 CHEK2
COSMIC (genes):CHEK2 CHEK2
CTD Gene:11200 CHEK2
dbSNP Gene:11200 CHEK2
ENSEMBL:ENSG00000183765 CHEK2
ENSEMBL_homo_sapiens_GENE:ENSG00000183765.24 CHEK2
HGNC:16627 CHEK2
KEGG Gene (Homo sapiens):11200 CHEK2
Monarch:11200 CHEK2
NCBI Gene:11200 CHEK2
OMIM:604373 CHEK2
UCSC:O96017 CHEK2
Reference Transcript
RefSeq:NM_007194.3 CHEK2
RefSeq:NM_145862.2 CHEK2
RefSeq:NM_001005735.1 CHEK2
RefSeq:XM_011529845.2 CHEK2
RefSeq:XM_017028561.1 CHEK2
RefSeq:NM_001257387.1 CHEK2
Other Identifiers
11200
11753669_x_at
11755467_x_at
16933502
210416_PM_s_at
210416_s_at
3582924
3582926
3658279
3688788
3689056
37887_at
3935863
3935864
3935866
3956444
3956445
3956447
3956449
3956450
3956451
3956452
3956453
3956454
3956456
3956457
3956458
3956459
3956464
3956467
3956468
3956469
3956470
3956473
3956474
3956475
3956476
3956477
3956480
3956482
8075164
A_23_P109452
A_33_P3386760
GO:0000077
GO:0000086
GO:0000166
GO:0000278
GO:0000781
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005794
GO:0006281
GO:0006302
GO:0006351
GO:0006355
GO:0006468
GO:0006915
GO:0006974
GO:0006977
GO:0006978
GO:0007010
GO:0007049
GO:0007059
GO:0008630
GO:0010332
GO:0012501
GO:0016301
GO:0016310
GO:0016605
GO:0016740
GO:0019901
GO:0023052
GO:0030163
GO:0031573
GO:0031625
GO:0036211
GO:0042176
GO:0042770
GO:0042771
GO:0042802
GO:0042803
GO:0043226
GO:0044773
GO:0045893
GO:0046777
GO:0046872
GO:0050821
GO:0051301
GO:0070242
GO:0071480
GO:0090307
GO:0090399
GO:0106310
GO:0140014
GO:0140096
GO:1901796
HMNXSV003018841
HMNXSV003035313
HMNXSV003046320
ILMN_1759585
ILMN_2395236
ILMN_2395240
PH_hs_0008730
PH_hs_0032531
g13278893_3p_a_at
Participates
as a component of
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Homo sapiens)
as an input of
CHEK2 is recruited to DNA DSBs (Homo sapiens)
Other forms of this molecule
p-T68-CHEK2 [nucleoplasm]
p-S,3T-CHEK2 [nucleoplasm]
Inferred To
CHEK2 [nucleoplasm]
(Bos taurus)
CHEK2 [nucleoplasm]
(Canis familiaris)
CHEK2 [nucleoplasm]
(Gallus gallus)
CHEK2 [nucleoplasm]
(Mus musculus)
CHEK2 [nucleoplasm]
(Rattus norvegicus)
CHEK2 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_009125.1
,
XP_011528147.1
,
XP_016884050.1
,
NP_001244316.1
,
NP_001005735.1
,
NP_665861.1
ZINC - World Drugs
CHK2_HUMAN
Guide to Pharmacology - Targets
1988
OpenTargets
ENSG00000183765
ZINC - FDA approved
CHK2_HUMAN
ZINC - Substances
CHK2_HUMAN
ZINC target
O96017
ZINC - Biogenic
CHK2_HUMAN
PRO
O96017
PDB
2CN5
,
4A9T
,
4BDG
,
2YCR
,
2XM9
,
4BDH
,
2XM8
,
2WTC
,
2YCQ
,
2XK9
,
4BDA
,
2YIR
,
2YIQ
,
4BDF
,
2CN8
,
2WTJ
,
2W7X
,
2WTI
,
2YCS
,
4A9U
,
2WTD
,
4BDK
,
4BDD
,
2YIT
,
4BDB
,
2W0J
,
4BDE
,
3I6W
,
3VA4
,
4BDI
,
4A9S
,
2XBJ
,
4A9R
,
4BDJ
,
1GXC
,
2YCF
,
3I6U
,
4BDC
ZINC - Investigational
CHK2_HUMAN
IntEnz
2.7.11.1
GeneCards
O96017
HPA
ENSG00000183765-CHEK2
Ensembl
ENST00000404276
,
ENST00000650281
,
ENST00000405598
,
ENST00000417588
,
ENST00000403642
,
ENSP00000329012
,
ENST00000348295
,
ENSP00000372023
,
ENST00000448511
,
ENSP00000404400
,
ENSP00000390244
,
ENST00000382580
,
ENST00000425190
,
ENSP00000497000
,
ENSP00000404567
,
ENSP00000386087
,
ENSP00000385747
,
ENST00000649563
,
ENST00000433728
,
ENSG00000183765
,
ENSP00000384919
,
ENSP00000412901
,
ENSP00000496928
Pharos - Targets
O96017
Orphanet
15444
ZINC - Predictions - Purchasable
CHK2_HUMAN
HMDB Protein
HMDBP01248
Interactors (27)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P52292 KPNA2
2
KPNA2 [nucleoplasm]
(R-HSA-206045)
KPNA2 [cytosol]
(R-HSA-205976)
0.733
7
UniProt:P53350 PLK1
4
PLK1 [nucleoplasm]
(R-HSA-156720)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
PLK1 [cytosol]
(R-HSA-164603)
0.72
7
UniProt:O96017 CHEK2
3
p-T68-CHEK2 [nucleoplasm]
(R-HSA-113825)
CHEK2 [nucleoplasm]
(R-HSA-113824)
p-S,3T-CHEK2 [nucleoplasm]
(R-HSA-5683784)
0.719
6
UniProt:Q00987 MDM2
11
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
monoSUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
MDM2 [plasma membrane]
(R-HSA-416843)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [cytosol]
(R-HSA-198644)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
0.66
6
UniProt:Q15172 PPP2R5A
2
p-S28-PPP2R5A [cytosol]
(R-HSA-9836658)
PPP2R5A [cytosol]
(R-HSA-196235)
0.658
3
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.646
3
UniProt:P18887 XRCC1
1
XRCC1 [nucleoplasm]
(R-HSA-67455)
0.645
8
UniProt:Q13362-3 PPP2R5C
0.633
4
UniProt:P30304 CDC25A
6
PolyUb-CDC25A [cytosol]
(R-HSA-6782810)
CDC25A [nucleoplasm]
(R-HSA-143487)
CDC25A [cytosol]
(R-HSA-157410)
p-S124-CDC25A [nucleoplasm]
(R-HSA-143488)
p-S124-CDC25A [cytosol]
(R-HSA-69588)
p-S40,S116,S261-CDC25A [nucleoplasm]
(R-HSA-8863634)
0.623
2
UniProt:Q9NY61 AATF
1
AATF [cytosol]
(R-HSA-205071)
0.602
4
UniProt:Q13362-1 PPP2R5C
0.602
3
UniProt:P06400 RB1
20
RB1 R661W [nucleoplasm]
(R-HSA-9659801)
RB1 C706F [nucleoplasm]
(R-HSA-9659812)
RB1 N480del [nucleoplasm]
(R-HSA-9659792)
RB1 C706Y [nucleoplasm]
(R-HSA-9659821)
RB1 R661Q [nucleoplasm]
(R-HSA-9659807)
RB1 I703_E737del [nucleoplasm]
(R-HSA-9661065)
RB1 R830_G887del [cytosol]
(R-HSA-9661059)
RB1 K791* [cytosol]
(R-HSA-9662284)
RB1 Q176* [cytosol]
(R-HSA-9661774)
RB1 S114* [cytosol]
(R-HSA-9661775)
RB1 K765* [cytosol]
(R-HSA-9662281)
RB1 W99* [cytosol]
(R-HSA-9661769)
RB1 S149* [cytosol]
(R-HSA-9661770)
RB1 E166* [cytosol]
(R-HSA-9661767)
RB1 G100* [cytosol]
(R-HSA-9661763)
RB1 E125* [cytosol]
(R-HSA-9661784)
RB1 Q121* [cytosol]
(R-HSA-9661780)
RB1 E184* [cytosol]
(R-HSA-9661781)
RB1 E137* [cytosol]
(R-HSA-9661782)
RB1 K745* [cytosol]
(R-HSA-9662288)
0.602
3
UniProt:Q93009 USP7
2
USP7 [cytosol]
(R-HSA-8853511)
USP7 [nucleoplasm]
(R-HSA-3215278)
0.59
2
UniProt:O15355 PPM1G
0.564
2
UniProt:P27958-PRO_0000037577
0.556
3
UniProt:Q96KN1 LRAT2
0.543
3
UniProt:Q9UQ88-1 CDK11A
0.524
2
UniProt:P55072 VCP
8
Me3K315-VCP [cytosol]
(R-HSA-8932209)
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [extracellular region]
(R-HSA-6806191)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [cytosol]
(R-HSA-1181251)
0.524
2
UniProt:Q5VTR2 RNF20
2
RNF20 [cytosol]
(R-HSA-9715141)
RNF20 [nucleoplasm]
(R-HSA-5689011)
0.508
3
UniProt:Q15173 PPP2R5B
2
p-S368-PPP2R5B [cytosol]
(R-HSA-6811453)
PPP2R5B [cytosol]
(R-HSA-535469)
0.508
2
UniProt:Q13362-2 PPP2R5C
0.508
2
UniProt:Q16537 PPP2R5E
1
PPP2R5E [cytosol]
(R-HSA-1638770)
0.508
3
UniProt:P0C6X7-PRO_0000037319 REP
0.508
2
UniProt:Q13007 IL24
1
IL24 [extracellular region]
(R-HSA-448438)
0.508
3
UniProt:Q9Y248 GINS2
1
GINS2 [nucleoplasm]
(R-HSA-176975)
0.499
2
UniProt:P56645 PER3
0.499
2
UniProt:P06725 UL83
1
CMVPP65 [viral tegument]
(R-HCY-5685583)
0.499
2
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