Reactome | CHEK2 [nucleoplasm]

CHEK2 [nucleoplasm]

Stable Identifier

R-HSA-113824

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Chk2, Serine/threonine-protein kinase Chk2 (EC 2.7.1.-) (Cds1), Serine/threonine-protein kinase Chk2 , Cds1

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Locations in the PathwayBrowser for interactor UniProt:Q96KN1

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External Reference Information

External Reference

UniProt:O96017 CHEK2

Gene Names

CHEK2, CDS1, CHK2, RAD53

Chain

chain:1-543

Reference Genes

BioGPS Gene:11200 CHEK2

COSMIC (genes):CHEK2 CHEK2

CTD Gene:11200 CHEK2

dbSNP Gene:11200 CHEK2

ENSEMBL:ENSG00000183765 CHEK2

HGNC:16627 CHEK2

KEGG Gene (Homo sapiens):11200 CHEK2

Monarch:11200 CHEK2

NCBI Gene:11200 CHEK2

OMIM:604373 CHEK2

UCSC:O96017 CHEK2

Reference Transcript

Other Identifiers

0002900711

11200

11753669_x_at

11755467_x_at

16933502

210416_s_at

3582924

3582926

3658279

3688788

3689056

37887_at

3935863

3935864

3935866

3956444

3956445

3956447

3956449

3956450

3956451

3956452

3956453

3956454

3956456

3956457

3956458

3956459

3956464

3956467

3956468

3956469

3956470

3956473

3956474

3956475

3956476

3956477

3956480

8075164

A_23_P109452

A_33_P3386760

GO:0000077

GO:0000086

GO:0000166

GO:0000278

GO:0000781

GO:0001934

GO:0003674

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005794

GO:0006259

GO:0006281

GO:0006302

GO:0006355

GO:0006464

GO:0006468

GO:0006915

GO:0006950

GO:0006974

GO:0006975

GO:0006977

GO:0006978

GO:0007010

GO:0007049

GO:0007165

GO:0007568

GO:0008150

GO:0008219

GO:0008630

GO:0009056

GO:0009058

GO:0010332

GO:0016301

GO:0016310

GO:0016605

GO:0016740

GO:0018105

GO:0019899

GO:0019901

GO:0022607

GO:0031625

GO:0034641

GO:0035690

GO:0042176

GO:0042770

GO:0042771

GO:0042802

GO:0042803

GO:0043167

GO:0043226

GO:0044257

GO:0044773

GO:0045893

GO:0046777

GO:0046872

GO:0050821

GO:0051301

GO:0071157

GO:0071480

GO:0072428

GO:0090307

GO:0090399

GO:0106310

GO:0106311

GO:0140014

GO:1901796

GO:1903416

GO:1903926

GO:2000002

GO:2000210

HMNXSV003018841

HMNXSV003035313

HMNXSV003046320

ILMN_1743378

ILMN_1759585

ILMN_2395236

PH_hs_0008730

PH_hs_0032531

g13278893_3p_a_at

Participates

as a component of

DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Homo sapiens)

as an input of

CHEK2 is recruited to DNA DSBs (Homo sapiens)

Other forms of this molecule

p-S,3T-CHEK2 [nucleoplasm]

p-T68-CHEK2 [nucleoplasm]

Inferred To

Chek2 [nucleoplasm] (Mus musculus)

Chek2 [nucleoplasm] (Rattus norvegicus)

Ghost homologue of CHEK2 [nucleoplasm] (Canis familiaris)

CHEK2 [nucleoplasm] (Gallus gallus)

CHEK2 [nucleoplasm] (Sus scrofa)

chek2 [nucleoplasm] (Danio rerio)

Cross References

RefSeq

XP_016884050.1, XP_011528147.1, NP_009125.1, NP_001244316.1, NP_665861.1, NP_001005735.1

ZINC - World Drugs

CHK2_HUMAN

OpenTargets

ENSG00000183765

ZINC - FDA approved

CHK2_HUMAN

ZINC - Substances

CHK2_HUMAN

ZINC - Biogenic

CHK2_HUMAN

ZINC target

O96017

PRO

O96017

PDB

2XM8, 4BDH, 2CN5, 4A9U, 2WTD, 2XK9, 2YIQ, 2YCS, 4A9T, 4BDG, 2XM9, 2CN8, 2W7X, 2YCR, 4BDF, 3VA4, 2XBJ, 4A9S, 2YCQ, 2WTC, 4A9R, 4BDE, 3I6W, 4BDD, 1GXC, 3I6U, 2YIT, 2YCF, 4BDC, 4BDK, 4BDJ, 4BDB, 2WTI, 4BDA, 2WTJ, 2W0J, 2YIR, 4BDI

ZINC - Investigational

CHK2_HUMAN

GeneCards

O96017

HPA

ENSG00000183765-CHEK2

Ensembl

ENST00000402731, ENSP00000404400, ENSP00000384919, ENSP00000385747, ENST00000348295, ENST00000448511, ENSP00000497000, ENST00000417588, ENSP00000372023, ENSP00000404567, ENST00000433728, ENSP00000412901, ENSP00000496928, ENSP00000329012, ENSP00000384835, ENSP00000386087, ENSG00000183765, ENST00000404276, ENST00000649563, ENST00000403642, ENST00000405598, ENST00000382580, ENST00000650281

Orphanet

15444

ZINC - Predictions - Purchasable

CHK2_HUMAN

HMDB Protein

HMDBP01248

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P52292 KPNA2	2	KPNA2 [nucleoplasm] (R-HSA-206045) KPNA2 [cytosol] (R-HSA-205976)	0.733	7
UniProt:P53350 PLK1	4	p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) PLK1 [cytosol] (R-HSA-164603)	0.72	7
UniProt:O96017 CHEK2	3	p-T68-CHEK2 [nucleoplasm] (R-HSA-113825) p-S,3T-CHEK2 [nucleoplasm] (R-HSA-5683784) CHEK2 [nucleoplasm] (R-HSA-113824)	0.719	6
UniProt:Q00987 MDM2	11	SUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.66	6
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.646	3
UniProt:P18887 XRCC1	1	XRCC1 [nucleoplasm] (R-HSA-67455)	0.645	8
UniProt:Q13362-3 PPP2R5C			0.633	4
UniProt:P30304 CDC25A	6	p-S123-CDC25A [nucleoplasm] (R-HSA-143488) CDC25A [nucleoplasm] (R-HSA-143487) CDC25A [cytosol] (R-HSA-157410) p-S123-CDC25A [cytosol] (R-HSA-69588) p-S40,S116,S261-CDC25A [nucleoplasm] (R-HSA-8863634) PolyUb-CDC25A [cytosol] (R-HSA-6782810)	0.623	2
UniProt:Q13362-1 PPP2R5C			0.602	3
UniProt:P06400 RB1	394	RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288) RB1 E209* [cytosol] (R-HSA-9661776) RB1 S618* [cytosol] (R-HSA-9662240) RB1 S463* [cytosol] (R-HSA-9662241) RB1 K720* [cytosol] (R-HSA-9662269) RB1 K429* [cytosol] (R-HSA-9662270) RB1 K652* [cytosol] (R-HSA-9662271) RB1 K715* [cytosol] (R-HSA-9662264) RB1 K615* [cytosol] (R-HSA-9662266) RB1 K412* [cytosol] (R-HSA-9662261) RB1 S567* [cytosol] (R-HSA-9662218) RB1 S807* [cytosol] (R-HSA-9662212) RB1 R467* [cytosol] (R-HSA-9662213) RB1 S834* [cytosol] (R-HSA-9662210) RB1 S576* [cytosol] (R-HSA-9662237) RB1 S758* [cytosol] (R-HSA-9662232) RB1 R7Pfs24 [cytosol] (R-HSA-9686292) RB1 S443 [cytosol] (R-HSA-9662230) RB1 S648* [cytosol] (R-HSA-9662224) RB1 S391* [cytosol] (R-HSA-9662225) RB1 S829* [cytosol] (R-HSA-9662226) RB1 D32Tfs33 [cytosol] (R-HSA-9688044) RB1 Y651Ifs7 [cytosol] (R-HSA-9688045) RB1 K143Mfs19 [cytosol] (R-HSA-9688046) RB1 V754Sfs4 [cytosol] (R-HSA-9688047) RB1 L44Rfs4 [cytosol] (R-HSA-9688040) RB1 E97Gfs13 [cytosol] (R-HSA-9688041) RB1 I679* [cytosol] (R-HSA-9688042) RB1 W195* [cytosol] (R-HSA-9689579) RB1 G100Efs11 [cytosol] (R-HSA-9688043) RB1 S648Tfs4 [cytosol] (R-HSA-9688036) RB1 H281Qfs6 [cytosol] (R-HSA-9688037) RB1 Q384 [cytosol] (R-HSA-9661925) RB1 S182Yfs2 [cytosol] (R-HSA-9688038) RB1 L343Sfs3 [cytosol] (R-HSA-9688039) RB1 L337Wfs12 [cytosol] (R-HSA-9688032) RB1 S318 [cytosol] (R-HSA-9688033) RB1 N627Mfs16 [cytosol] (R-HSA-9688034) RB1 N290Kfs20 [cytosol] (R-HSA-9688035) RB1 F299Lfs4 [cytosol] (R-HSA-9688060) RB1 Q637 [cytosol] (R-HSA-9662460) RB1 L76* [cytosol] (R-HSA-9688061) RB1 Q762* [cytosol] (R-HSA-9662461) RB1 Y655Lfs4 [cytosol] (R-HSA-9688062) RB1 N480Kfs13 [cytosol] (R-HSA-9688063) RB1 Q444* [cytosol] (R-HSA-9662463) RB1 T77Lfs34 [cytosol] (R-HSA-9688056) RB1 E747Gfs3 [cytosol] (R-HSA-9688057) RB1 M825* [cytosol] (R-HSA-9688058) RB1 L649Ffs11 [cytosol] (R-HSA-9688059) RB1 N472Ifs6 [cytosol] (R-HSA-9688052) RB1 Y813Kfs12 [cytosol] (R-HSA-9688053) RB1 I324Mfs17 [cytosol] (R-HSA-9688054) RB1 M460Ifs3 [cytosol] (R-HSA-9688055) RB1 Y655Ifs3 [cytosol] (R-HSA-9688048) RB1 L769Cfs41 [cytosol] (R-HSA-9688049) RB1 P28Lfs37 [cytosol] (R-HSA-9688050) RB1 E677Dfs19 [cytosol] (R-HSA-9688051) RB1 P370Lfs10 [cytosol] (R-HSA-9688012) RB1 N593Tfs11 [cytosol] (R-HSA-9688013) RB1 K329 [cytosol] (R-HSA-9661901) RB1 S249Ffs22 [cytosol] (R-HSA-9688014) RB1 K240 [cytosol] (R-HSA-9661902) RB1 L199Ffs4 [cytosol] (R-HSA-9688015) RB1 P253Gfs5 [cytosol] (R-HSA-9688008) RB1 K289* [cytosol] (R-HSA-9661896) RB1 S360Pfs2 [cytosol] (R-HSA-9688009) RB1 E323Kfs9 [cytosol] (R-HSA-9688010) RB1 L326* [cytosol] (R-HSA-9688011) RB1 P808Kfs12 [cytosol] (R-HSA-9688004) RB1 D584Nfs2 [cytosol] (R-HSA-9688005) RB1 N406Kfs4 [cytosol] (R-HSA-9688006) RB1 K417Wfs23 [cytosol] (R-HSA-9688007) RB1 L797Ffs18 [cytosol] (R-HSA-9688000) RB1 Q266Hfs2 [cytosol] (R-HSA-9688001) RB1 R255* [cytosol] (R-HSA-9661889) RB1 K4* [cytosol] (R-HSA-9661377) RB1 P641Afs12 [cytosol] (R-HSA-9688002) RB1 V450Sfs13 [cytosol] (R-HSA-9688003) RB1 K524Rfs28 [cytosol] (R-HSA-9688028) RB1 E280 [cytosol] (R-HSA-9661916) RB1 M825Ifs13 [cytosol] (R-HSA-9688029) RB1 M761Nfs21 [cytosol] (R-HSA-9688030) RB1 A11Rfs20 [cytosol] (R-HSA-9688031) RB1 E275 [cytosol] (R-HSA-9661919) RB1 A635Gfs6 [cytosol] (R-HSA-9688024) RB1 Q266 [cytosol] (R-HSA-9661912) RB1 I66Yfs11 [cytosol] (R-HSA-9688025) RB1 Q257 [cytosol] (R-HSA-9661913) RB1 P39Rfs26 [cytosol] (R-HSA-9688026) RB1 T664Nfs4 [cytosol] (R-HSA-9688027) RB1 Y771Lfs24 [cytosol] (R-HSA-9688020) RB1 R320Dfs12 [cytosol] (R-HSA-9688021) RB1 E282* [cytosol] (R-HSA-9661909) RB1 L277Pfs9 [cytosol] (R-HSA-9688022) RB1 I124 [cytosol] (R-HSA-9688023) RB1 N803Tfs7 [cytosol] (R-HSA-9688016) RB1 M386Ifs11 [cytosol] (R-HSA-9688017) RB1 E72Vfs34 [cytosol] (R-HSA-9688018) RB1 R150Kfs7 [cytosol] (R-HSA-9688019) RB1 L743* [cytosol] (R-HSA-9687980) RB1 R7Efs58 [cytosol] (R-HSA-9687981) RB1 T140Nfs6 [cytosol] (R-HSA-9687982) RB1 D479Efs16 [cytosol] (R-HSA-9687983) RB1 L199 [cytosol] (R-HSA-9661871) RB1 G801* [cytosol] (R-HSA-9662377) RB1 S215* [cytosol] (R-HSA-9661866) RB1 G435* [cytosol] (R-HSA-9662368) RB1 G581* [cytosol] (R-HSA-9662369) RB1 L134* [cytosol] (R-HSA-9687996) RB1 Y529Lfs26 [cytosol] (R-HSA-9687997) RB1 S816Qfs10 [cytosol] (R-HSA-9687998) RB1 E693Nfs3 [cytosol] (R-HSA-9687999) RB1 D346Rfs4 [cytosol] (R-HSA-9687992) RB1 Q35* [cytosol] (R-HSA-9661368) RB1 I806Lfs10 [cytosol] (R-HSA-9687993) RB1 E54 [cytosol] (R-HSA-9661369) RB1 L199Yfs2 [cytosol] (R-HSA-9687994) RB1 E48 [cytosol] (R-HSA-9661370) RB1 N854* [cytosol] (R-HSA-9687995) RB1 W75* [cytosol] (R-HSA-9661371) RB1 L389Ffs3 [cytosol] (R-HSA-9687988) RB1 S230 [cytosol] (R-HSA-9661876) RB1 H483Sfs10 [cytosol] (R-HSA-9687989) RB1 S842 [cytosol] (R-HSA-9687990) RB1 W78* [cytosol] (R-HSA-9661366) RB1 G449Efs8 [cytosol] (R-HSA-9687991) RB1 K63 [cytosol] (R-HSA-9661367) RB1 K537Nfs14 [cytosol] (R-HSA-9687984) RB1 L206 [cytosol] (R-HSA-9661872) RB1 K63Rfs38 [cytosol] (R-HSA-9687985) RB1 P732Lfs12 [cytosol] (R-HSA-9687986) RB1 L158* [cytosol] (R-HSA-9661874) RB1 A562Hfs49 [cytosol] (R-HSA-9687987) RB1 E72 [cytosol] (R-HSA-9661363) RB1 G540Afs3 [cytosol] (R-HSA-9688172) RB1 N328Ifs4 [cytosol] (R-HSA-9688173) RB1 E843* [cytosol] (R-HSA-9662573) RB1 L385* [cytosol] (R-HSA-9688174) RB1 E464* [cytosol] (R-HSA-9662574) RB1 N123Tfs2 [cytosol] (R-HSA-9688175) RB1 E112Dfs6 [cytosol] (R-HSA-9688168) RB1 E748* [cytosol] (R-HSA-9662568) RB1 M148Ifs8 [cytosol] (R-HSA-9688169) RB1 R661 [cytosol] (R-HSA-9688170) RB1 Y453* [cytosol] (R-HSA-9688164) RB1 K95* [cytosol] (R-HSA-9661540) RB1 M484Vfs8 [cytosol] (R-HSA-9688165) RB1 E533 [cytosol] (R-HSA-9662565) RB1 G86* [cytosol] (R-HSA-9661541) RB1 V654Sfs14 [cytosol] (R-HSA-9688166) RB1 E747 [cytosol] (R-HSA-9662566) RB1 E79* [cytosol] (R-HSA-9661542) RB1 C553Wfs53 [cytosol] (R-HSA-9688167) RB1 E677 [cytosol] (R-HSA-9662567) RB1 K96* [cytosol] (R-HSA-9661543) RB1 C102Yfs7 [cytosol] (R-HSA-9688160) RB1 E737 [cytosol] (R-HSA-9662560) RB1 E97* [cytosol] (R-HSA-9661536) RB1 R579Qfs29 [cytosol] (R-HSA-9688161) RB1 A525Pfs7 [cytosol] (R-HSA-9688162) RB1 L542Kfs11 [cytosol] (R-HSA-9688163) RB1 F482Sfs10 [cytosol] (R-HSA-9688188) RB1 L797* [cytosol] (R-HSA-9688189) RB1 P250Afs16 [cytosol] (R-HSA-9688190) RB1 S194Ffs7 [cytosol] (R-HSA-9688191) RB1 N623Qfs15 [cytosol] (R-HSA-9688184) RB1 T9Rfs56 [cytosol] (R-HSA-9688185) RB1 Y813Qfs10 [cytosol] (R-HSA-9688187) RB1 I768Cfs23 [cytosol] (R-HSA-9688180) RB1 L477Mfs17 [cytosol] (R-HSA-9688181) RB1 E675 [cytosol] (R-HSA-9662581) RB1 V654Cfs4 [cytosol] (R-HSA-9688182) RB1 F650Lfs5 [cytosol] (R-HSA-9688183) RB1 P39Sfs10 [cytosol] (R-HSA-9688176) RB1 H281Sfs2 [cytosol] (R-HSA-9688177) RB1 E551* [cytosol] (R-HSA-9662577) RB1 C61Vfs4 [cytosol] (R-HSA-9688178) RB1 D145Ifs8 [cytosol] (R-HSA-9688179) RB1 M148Hfs9 [cytosol] (R-HSA-9688140) RB1 E837 [cytosol] (R-HSA-9662540) RB1 L158Mfs19 [cytosol] (R-HSA-9688141) RB1 L832Ffs5 [cytosol] (R-HSA-9688142) RB1 E440* [cytosol] (R-HSA-9662542) RB1 D224Afs40 [cytosol] (R-HSA-9688136) RB1 P822Qfs4 [cytosol] (R-HSA-9688137) RB1 M148Vfs8 [cytosol] (R-HSA-9688138) RB1 L670Cfs7 [cytosol] (R-HSA-9688139) RB1 E465* [cytosol] (R-HSA-9662532) RB1 S414Kfs14 [cytosol] (R-HSA-9688133) RB1 K548Nfs3 [cytosol] (R-HSA-9688134) RB1 L135Tfs5 [cytosol] (R-HSA-9688135) RB1 Q207Tfs5 [cytosol] (R-HSA-9688128) RB1 Q384Tfs11 [cytosol] (R-HSA-9688129) RB1 L797Ffs14 [cytosol] (R-HSA-9688130) RB1 P232Rfs4 [cytosol] (R-HSA-9688131) RB1 T497Hfs22 [cytosol] (R-HSA-9688156) RB1 E817* [cytosol] (R-HSA-9662556) RB1 N367* [cytosol] (R-HSA-9688157) RB1 L809Rfs17 [cytosol] (R-HSA-9688158) RB1 E693 [cytosol] (R-HSA-9662558) RB1 K80* [cytosol] (R-HSA-9661534) RB1 W99Lfs11 [cytosol] (R-HSA-9688159) RB1 A15Pfs3 [cytosol] (R-HSA-9688152) RB1 Y239Lfs25 [cytosol] (R-HSA-9688153) RB1 D571Lfs41 [cytosol] (R-HSA-9688154) RB1 N186Ifs6 [cytosol] (R-HSA-9688155) RB1 E837Dfs12 [cytosol] (R-HSA-9688148) RB1 E672* [cytosol] (R-HSA-9662548) RB1 H483Yfs9 [cytosol] (R-HSA-9688149) RB1 R775Gfs35 [cytosol] (R-HSA-9688150) RB1 E580* [cytosol] (R-HSA-9662550) RB1 G617Rfs36 [cytosol] (R-HSA-9688151) RB1 E492 [cytosol] (R-HSA-9662551) RB1 A333Ffs13 [cytosol] (R-HSA-9688144) RB1 L564Sfs47 [cytosol] (R-HSA-9688145) RB1 D156Vfs19 [cytosol] (R-HSA-9688147) RB1 C438Vfs19 [cytosol] (R-HSA-9688108) RB1 C278* [cytosol] (R-HSA-9688109) RB1 E209Vfs3 [cytosol] (R-HSA-9688110) RB1 T116Lfs8 [cytosol] (R-HSA-9688111) RB1 R698Afs22 [cytosol] (R-HSA-9688104) RB1 V419 [cytosol] (R-HSA-9688105) RB1 I415Nfs13 [cytosol] (R-HSA-9688106) RB1 Y173Ffs11 [cytosol] (R-HSA-9688107) RB1 N133Tfs3 [cytosol] (R-HSA-9688100) RB1 M695Rfs10 [cytosol] (R-HSA-9688101) RB1 R418Sfs9 [cytosol] (R-HSA-9688102) RB1 Q689 [cytosol] (R-HSA-9662502) RB1 A74Efs4 [cytosol] (R-HSA-9688103) RB1 W99Yfs5 [cytosol] (R-HSA-9688096) RB1 G442Dfs15 [cytosol] (R-HSA-9688097) RB1 N258Efs11 [cytosol] (R-HSA-9688098) RB1 S182Ifs3 [cytosol] (R-HSA-9688099) RB1 Q436 [cytosol] (R-HSA-9662499) RB1 Q395Pfs11 [cytosol] (R-HSA-9688124) RB1 Y606Lfs47 [cytosol] (R-HSA-9688125) RB1 E539* [cytosol] (R-HSA-9662525) RB1 L317* [cytosol] (R-HSA-9688126) RB1 F104Lfs7 [cytosol] (R-HSA-9688127) RB1 E691 [cytosol] (R-HSA-9662527) RB1 D340Yfs5 [cytosol] (R-HSA-9688120) RB1 K740Tfs10 [cytosol] (R-HSA-9688121) RB1 H483Ifs12 [cytosol] (R-HSA-9688122) RB1 R611Lfs43 [cytosol] (R-HSA-9688123) RB1 V291Ifs9 [cytosol] (R-HSA-9688116) RB1 N133 [cytosol] (R-HSA-9688117) RB1 R334* [cytosol] (R-HSA-9688118) RB1 D697Qfs23 [cytosol] (R-HSA-9688119) RB1 L647Ffs5 [cytosol] (R-HSA-9688112) RB1 I723Nfs28 [cytosol] (R-HSA-9688113) RB1 L486Ifs6 [cytosol] (R-HSA-9688114) RB1 S565* [cytosol] (R-HSA-9688115) RB1 Y529Tfs3 [cytosol] (R-HSA-9688076) RB1 Q631 [cytosol] (R-HSA-9662476) RB1 S318Nfs13 [cytosol] (R-HSA-9688077) RB1 D856Efs17 [cytosol] (R-HSA-9688078) RB1 P595Lfs16 [cytosol] (R-HSA-9688079) RB1 P777Lfs33 [cytosol] (R-HSA-9688072) RB1 G310Dfs22 [cytosol] (R-HSA-9688073) RB1 P250Sfs20 [cytosol] (R-HSA-9688074) RB1 Q850* [cytosol] (R-HSA-9662474) RB1 I124Rfs6 [cytosol] (R-HSA-9688075) RB1 Q702 [cytosol] (R-HSA-9662475) RB1 E748Dfs6 [cytosol] (R-HSA-9688068) RB1 Q736 [cytosol] (R-HSA-9662468) RB1 R798Qfs4 [cytosol] (R-HSA-9688069) RB1 S588Ffs6 [cytosol] (R-HSA-9688070) RB1 K574* [cytosol] (R-HSA-9688071) RB1 D156Mfs19 [cytosol] (R-HSA-9688064) RB1 Y771Cfs23 [cytosol] (R-HSA-9688065) RB1 I66Dfs44 [cytosol] (R-HSA-9688066) RB1 Q685 [cytosol] (R-HSA-9662466) RB1 E125Kfs11 [cytosol] (R-HSA-9688067) RB1 Y655Lfs13 [cytosol] (R-HSA-9688092) RB1 R828Kfs10 [cytosol] (R-HSA-9688093) RB1 Y659Ifs4 [cytosol] (R-HSA-9688094) RB1 Q846* [cytosol] (R-HSA-9662494) RB1 E97Nfs14 [cytosol] (R-HSA-9688095) RB1 Q770 [cytosol] (R-HSA-9662495) RB1 C666* [cytosol] (R-HSA-9688088) RB1 Q471* [cytosol] (R-HSA-9662488) RB1 R71Efs39 [cytosol] (R-HSA-9688089) RB1 Q504 [cytosol] (R-HSA-9662489) RB1 R798Tfs17 [cytosol] (R-HSA-9688090) RB1 Q639 [cytosol] (R-HSA-9662490) RB1 N328* [cytosol] (R-HSA-9688091) RB1 S576Rfs34 [cytosol] (R-HSA-9688084) RB1 T726Nfs25 [cytosol] (R-HSA-9688085) RB1 Q597* [cytosol] (R-HSA-9662485) RB1 I532Nfs57 [cytosol] (R-HSA-9688086) RB1 K577Rfs34 [cytosol] (R-HSA-9688087) RB1 R73Sfs36 [cytosol] (R-HSA-9688080) RB1 E413Kfs4 [cytosol] (R-HSA-9688081) RB1 K844Sfs5 [cytosol] (R-HSA-9688082) RB1 A17Pfs3 [cytosol] (R-HSA-9688083) RB1 Q395* [cytosol] (R-HSA-9660655) RB1 L523* [cytosol] (R-HSA-9662176) RB1 R251* [cytosol] (R-HSA-9660640) RB1 L389* [cytosol] (R-HSA-9662178) RB1 Q217* [cytosol] (R-HSA-9660668) RB1 Q344* [cytosol] (R-HSA-9660669) RB1 S634* [cytosol] (R-HSA-9662207) RB1 S565* [cytosol] (R-HSA-9662200) RB1 S397* [cytosol] (R-HSA-9662202) RB1 S838* [cytosol] (R-HSA-9662203) RB1 R556* [cytosol] (R-HSA-9660661) RB1 R787* [cytosol] (R-HSA-9660656) RB1 G304* [cytosol] (R-HSA-9662152) RB1 W516* [cytosol] (R-HSA-9662660) RB1 W681* [cytosol] (R-HSA-9662661) RB1 E322* [cytosol] (R-HSA-9662149) RB1 W563* [cytosol] (R-HSA-9662656) RB1 L550* [cytosol] (R-HSA-9662173) RB1 R552* [cytosol] (R-HSA-9660637) RB1 L512* [cytosol] (R-HSA-9662168) RB1 R455* [cytosol] (R-HSA-9660632) RB1 R763* [cytosol] (R-HSA-9662681) RB1 L779* [cytosol] (R-HSA-9662169) RB1 R445* [cytosol] (R-HSA-9660633) RB1 R544* [cytosol] (R-HSA-9662677) RB1 R320* [cytosol] (R-HSA-9660630) RB1 L832* [cytosol] (R-HSA-9662167) RB1 Y498* [cytosol] (R-HSA-9662634) RB1 Y446* [cytosol] (R-HSA-9662628) RB1 Y655* [cytosol] (R-HSA-9662629) RB1 E323* [cytosol] (R-HSA-9662142) RB1 E364* [cytosol] (R-HSA-9662143) RB1 C489* [cytosol] (R-HSA-9662649) RB1 G310* [cytosol] (R-HSA-9662137) RB1 L335* [cytosol] (R-HSA-9662139) RB1 E313* [cytosol] (R-HSA-9662133) RB1 E315* [cytosol] (R-HSA-9662131) RB1 D479Vfs14 [cytosol] (R-HSA-9688204) RB1 C489Lfs5 [cytosol] (R-HSA-9688205) RB1 Y454* [cytosol] (R-HSA-9662605) RB1 E137Rfs3 [cytosol] (R-HSA-9688206) RB1 L676Ffs16 [cytosol] (R-HSA-9688207) RB1 Y728* [cytosol] (R-HSA-9662607) RB1 I799Ffs11 [cytosol] (R-HSA-9688200) RB1 D346Vfs17 [cytosol] (R-HSA-9688201) RB1 F514Pfs8 [cytosol] (R-HSA-9688202) RB1 N593Sfs5 [cytosol] (R-HSA-9688203) RB1 T58Yfs52 [cytosol] (R-HSA-9688196) RB1 N522Ifs2 [cytosol] (R-HSA-9688197) RB1 C553Vfs58 [cytosol] (R-HSA-9688198) RB1 P609Cfs43 [cytosol] (R-HSA-9688199) RB1 N269* [cytosol] (R-HSA-9688192) RB1 E287Rfs2 [cytosol] (R-HSA-9688193) RB1 E492Lfs4 [cytosol] (R-HSA-9688194) RB1 Q383Nfs3 [cytosol] (R-HSA-9688195) RB1 Y606 [cytosol] (R-HSA-9662617) RB1 Y756* [cytosol] (R-HSA-9662619) RB1 Y790* [cytosol] (R-HSA-9662612) RB1 T502Nfs17 [cytosol] (R-HSA-9688208) RB1 Y709 [cytosol] (R-HSA-9662608) RB1 Y749* [cytosol] (R-HSA-9662611) RB1 T738_R775del [nucleoplasm] (R-HSA-9661042) hyperphosphorylated RB1 [nucleoplasm] (R-HSA-188389) RB1 [cytosol] (R-HSA-9660621) p-S249-RB1 [nucleoplasm] (R-HSA-9687343) p-S230-RB1 [nucleoplasm] (R-HSA-9687336) p-T356-RB1 [nucleoplasm] (R-HSA-9687339) p-T826-RB1 [nucleoplasm] (R-HSA-9687334) p-S252-RB1 [nucleoplasm] (R-HSA-9687335) p-S807-RB1 [nucleoplasm] (R-HSA-9687356) p-T821-RB1 [nucleoplasm] (R-HSA-9687357) p-S795-RB1 [nucleoplasm] (R-HSA-69226) p-S612-RB1 [nucleoplasm] (R-HSA-9687352) p-S780-RB1 [nucleoplasm] (R-HSA-9687353) p-S811-RB1 [nucleoplasm] (R-HSA-9687354) RB1 [nucleoplasm] (R-HSA-68642) p-S788-RB1 [nucleoplasm] (R-HSA-9687347) p-S608-RB1 [nucleoplasm] (R-HSA-9687351) p-T373-RB1 [nucleoplasm] (R-HSA-9687355)	0.602	3
UniProt:Q9NY61 AATF	1	AATF [cytosol] (R-HSA-205071)	0.602	4
UniProt:P27958-PRO_0000037577			0.556	3
UniProt:Q96KN1 LRAT2			0.543	3
UniProt:Q9UQ88-1 CDK11A			0.524	2
UniProt:P55072 VCP	8	VCP [endoplasmic reticulum membrane] (R-HSA-8943105) Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [nucleoplasm] (R-HSA-5643745) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [extracellular region] (R-HSA-6806191) VCP [secretory granule lumen] (R-HSA-6801039) VCP [cytosol] (R-HSA-1181251)	0.524	2
UniProt:Q5VTR2 RNF20	2	RNF20 [nucleoplasm] (R-HSA-5689011) RNF20 [cytosol] (R-HSA-9715141)	0.508	3
UniProt:Q15172 PPP2R5A	1	PPP2R5A [cytosol] (R-HSA-196235)	0.508	2
UniProt:Q13362-2 PPP2R5C			0.508	2
UniProt:Q16537 PPP2R5E	1	PPP2R5E [cytosol] (R-HSA-1638770)	0.508	3
UniProt:P0C6X7-PRO_0000037319 REP			0.508	2
UniProt:Q13007 IL24	1	IL24 [extracellular region] (R-HSA-448438)	0.508	3
UniProt:Q15173 PPP2R5B	2	PPP2R5B [cytosol] (R-HSA-535469) p-S368-PPP2R5B [cytosol] (R-HSA-6811453)	0.508	2
UniProt:P56645 PER3			0.499	2
UniProt:Q9Y248 GINS2	1	GINS2 [nucleoplasm] (R-HSA-176975)	0.499	2
UniProt:P06725 UL83	1	CMVPP65 [viral tegument] (R-HCY-5685583)	0.499	2

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