Reactome: A Curated Pathway Database

p-T68-CHEK2

Stable Identifier
R-HSA-113825
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
phospho-Chk2, Serine/threonine-protein kinase Chk2 (EC 2.7.1.-) (Cds1) phosphorylated, Serine/threonine-protein kinase Chk2 , Cds1
Locations in the PathwayBrowser
External Reference Information
External Reference
Gene Names
CHEK2, CDS1, CHK2, RAD53
Chain
chain:1-543
Reference Genes
Reference Transcript
Other Identifiers
 0002900711  11200  11753669_x_at  11755467_x_at  16933502
 1878  1GXC  2030  210416_s_at  2CN5
 2CN8  2W0J  2W7X  2WTC  2WTD
 2WTI  2WTJ  2XBJ  2XK9  2XM8
 2XM9  2YCF  2YCQ  2YCR  2YCS
 2YIQ  2YIR  2YIT  3582924  3582926
 3658279  3688788  3689056  37887_at  3935863
 3935864  3935866  3956444  3956445  3956447
 3956449  3956450  3956451  3956452  3956453
 3956454  3956456  3956457  3956458  3956459
 3956464  3956467  3956468  3956469  3956470
 3956473  3956474  3956475  3956476  3956477
 3956480  3I6U  3I6W  3VA4  4A9R
 4A9S  4A9T  4A9U  4BDA  4BDB
 4BDC  4BDD  4BDE  4BDF  4BDG
 4BDH  4BDI  4BDJ  4BDK  8075164
 A_23_P109452  A_33_P3386760  AAC83693  AAD11784  AAD48504
 AAG17218  AAH04207  AAS58456  AAS58457  AAS58458
 AAS58459  AAS58460  AAS58461  AAS58462  AAS58463
 AAS58464  AAS58465  AAS58466  AAV41895  AB040105
 AF086904  AF096279  AF174135  AF217975  AJ131197
 AK290754  AL117330  AL121825  AY551295  AY551296
 AY551297  AY551298  AY551299  AY551300  AY551301
 AY551302  AY551303  AY551304  AY551305  AY800241
 BAB17231  BAF83443  BC004207  CAA10319  CAB002030
 CAG30304  CAH73823  CAH73875  CAX11957  CAX11958
 CAX11959  CAX14026  CAX14027  CAX14028  CCDS13843
 CCDS13844  CCDS33629  CH471095  CHEK2  CHEK2-201
 CHEK2-202  CHEK2-204  CHEK2-206  CHEK2-207  CHEK2-208
 CHEK2-209  CHEK2-211  CHEK2-214  CHEK2-219  CR456418
 EAW59755  ENSG00000183765  ENSP00000329012  ENSP00000329178  ENSP00000372023
 ENSP00000384835  ENSP00000384919  ENSP00000385747  ENSP00000386087  ENSP00000404400
 ENSP00000404567  ENSP00000412901  ENST00000328354  ENST00000348295  ENST00000382580
 ENST00000402731  ENST00000403642  ENST00000404276  ENST00000405598  ENST00000417588
 ENST00000433728  ENST00000448511  EntrezGene:11200  g13278893_3p_a_at  GO:0000077
 GO:0000086  GO:0000166  GO:0000278  GO:0000781  GO:0001302
 GO:0001934  GO:0003674  GO:0004672  GO:0004674  GO:0005515
 GO:0005524  GO:0005575  GO:0005622  GO:0005623  GO:0005634
 GO:0005654  GO:0005694  GO:0005737  GO:0005794  GO:0006259
 GO:0006281  GO:0006302  GO:0006351  GO:0006355  GO:0006464
 GO:0006468  GO:0006915  GO:0006950  GO:0006974  GO:0006975
 GO:0006977  GO:0006978  GO:0007010  GO:0007049  GO:0007165
 GO:0007568  GO:0008150  GO:0008219  GO:0008630  GO:0009056
 GO:0009058  GO:0010332  GO:0016301  GO:0016310  GO:0016605
 GO:0016740  GO:0018105  GO:0018107  GO:0019899  GO:0019901
 GO:0022607  GO:0031625  GO:0034641  GO:0035690  GO:0042176
 GO:0042770  GO:0042771  GO:0042802  GO:0042803  GO:0042981
 GO:0043167  GO:0043226  GO:0044257  GO:0045893  GO:0046777
 GO:0046872  GO:0050821  GO:0051301  GO:0071157  GO:0071480
 GO:0072428  GO:0090307  GO:0090399  GO:0140014  GO:1901796
 GO:1903416  GO:1903926  GO:2000002  GO:2000210  HGNC:16627
 HPA001878  Hs.291363  ILMN_1743378  ILMN_1759585  ILMN_2395236
 IPR000253  IPR000719  IPR001245  IPR008271  IPR008984
 IPR011009  IPR020636  MIM:114480  MIM:176807  MIM:259500
 MIM:604373  MIM:609265  NM_001005735  NM_001257387  NM_007194
 NM_145862  NP_001005735  NP_001244316  NP_009125  NP_665861
 PF00069  PF00498  PF07714  PH_hs_0008730  PH_hs_0032531
 PR02045  SM00220  SM00240  uc003adt.2  uc003adu.2
 uc003adv.1  uc010gvh.2  uc062cuf.1  uc062cuh.1  uc062cui.1
 uc062cuj.1  uc062cuk.1  uc062cul.1  UPI00000316FF  UPI000006EA3C
 UPI000034E4A3  UPI000034E4A4  UPI000034E4A6  UPI000034E4A7  UPI000034E4A8
 XM_011529839  XM_011529840  XM_011529841  XM_011529842  XM_011529843
 XM_011529845  XM_017028560  XM_017028561  XP_011528141  XP_011528142
 XP_011528143  XP_011528144  XP_011528147  XP_016884049  XP_016884050
 XR_937805
Participant Of
Other forms of this molecule
Inferred To
Modified Residues
Name Coordinate Modification PsiMod
O-phospho-L-threonine at 68 68
O-phospho-L-threonine [MOD:00047] A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
ZINC - World Drugs
ZINC - FDA approved
ZINC - Substances
ZINC target
PRO
UCSC human
GeneCards
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors
Confidence Score Interactor Accession Interactor Name Evidence (IntAct)
0.733 P52292 IMA1_HUMAN 7
0.719 O96017 CHK2_HUMAN 6
0.66 Q00987 MDM2_HUMAN 6
0.646 P04637 P53_HUMAN 3
0.645 P18887 XRCC1_HUMAN 8
0.633 Q13362-3 PPP2R5C 4
0.623 P30304 MPIP1_HUMAN 2
0.619 P53350 PLK1_HUMAN 6
0.602 Q13362-1 PPP2R5C 3
0.602 P06400 RB_HUMAN 3
0.602 Q9NY61 AATF_HUMAN 4
0.556 P27958-PRO_0000037577 3
0.543 Q96KN1 FA84B_HUMAN 3
0.524 P55072 TERA_HUMAN 2
0.524 Q9UQ88-1 CDK11A 2
0.508 Q13362-2 PPP2R5C 2
0.508 Q15173 2A5B_HUMAN 2
0.508 Q15172 2A5A_HUMAN 2
0.508 Q5VTR2 BRE1A_HUMAN 3
0.508 Q16537 2A5E_HUMAN 3
0.508 Q13007 IL24_HUMAN 3
0.499 P56645 PER3_HUMAN 2
0.499 Q9Y248 PSF2_HUMAN 2