Reactome | p-T68-CHEK2 [nucleoplasm]

p-T68-CHEK2 [nucleoplasm]

Stable Identifier

R-HSA-113825

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

phospho-Chk2, Serine/threonine-protein kinase Chk2 (EC 2.7.1.-) (Cds1) phosphorylated, Serine/threonine-protein kinase Chk2 , Cds1

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External Reference Information

External Reference

UniProt:O96017 CHEK2

Gene Names

CHEK2, CDS1, CHK2, RAD53

Chain

chain:1-543

Reference Genes

BioGPS Gene:11200 CHEK2

COSMIC (genes):CHEK2 CHEK2

CTD Gene:11200 CHEK2

dbSNP Gene:11200 CHEK2

ENSEMBL:ENSG00000183765 CHEK2

ENSEMBL_homo_sapiens_GENE:ENSG00000183765.24 CHEK2

HGNC:16627 CHEK2

KEGG Gene (Homo sapiens):11200 CHEK2

Monarch:11200 CHEK2

NCBI Gene:11200 CHEK2

OMIM:604373 CHEK2

UCSC:O96017 CHEK2

Reference Transcript

Other Identifiers

11200

11753669_x_at

11755467_x_at

16933502

210416_PM_s_at

210416_s_at

3582924

3582926

3658279

3688788

3689056

37887_at

3935863

3935864

3935866

3956444

3956445

3956447

3956449

3956450

3956451

3956452

3956453

3956454

3956456

3956457

3956458

3956459

3956464

3956467

3956468

3956469

3956470

3956473

3956474

3956475

3956476

3956477

3956480

3956482

8075164

A_23_P109452

A_33_P3386760

GO:0000077

GO:0000086

GO:0000166

GO:0000278

GO:0000781

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005794

GO:0006281

GO:0006302

GO:0006351

GO:0006355

GO:0006468

GO:0006915

GO:0006974

GO:0006977

GO:0006978

GO:0007010

GO:0007049

GO:0007059

GO:0008630

GO:0010332

GO:0012501

GO:0016301

GO:0016310

GO:0016605

GO:0016740

GO:0019901

GO:0023052

GO:0030163

GO:0031573

GO:0031625

GO:0036211

GO:0042176

GO:0042770

GO:0042771

GO:0042802

GO:0042803

GO:0043226

GO:0044773

GO:0045893

GO:0046777

GO:0046872

GO:0050821

GO:0051301

GO:0070242

GO:0071480

GO:0090307

GO:0090399

GO:0106310

GO:0140014

GO:0140096

GO:1901796

HMNXSV003018841

HMNXSV003035313

HMNXSV003046320

ILMN_1759585

ILMN_2395236

ILMN_2395240

PH_hs_0008730

PH_hs_0032531

g13278893_3p_a_at

Participates

as a component of

p-T68-CHEK2 dimer [nucleoplasm] (Homo sapiens)

as an input of

p-T68-CHEK2 dimerizes (Homo sapiens)

as an output of

Phosphorylation and activation of CHEK2 by ATM (Homo sapiens)

Other forms of this molecule

CHEK2 [nucleoplasm]

p-S,3T-CHEK2 [nucleoplasm]

Inferred To

Homologues of p-T68-CHEK2 [nucleoplasm] (Saccharomyces cerevisiae)

phospho-p-T68-CHEK2 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-T68-CHEK2 [nucleoplasm] (Dictyostelium discoideum)

phospho-p-T68-CHEK2 [nucleoplasm] (Drosophila melanogaster)

phospho-p-T68-CHEK2 [nucleoplasm] (Gallus gallus)

phospho-p-T68-CHEK2 [nucleoplasm] (Mus musculus)

phospho-p-T68-CHEK2 [nucleoplasm] (Plasmodium falciparum)

phospho-p-T68-CHEK2 [nucleoplasm] (Rattus norvegicus)

phospho-p-T68-CHEK2 [nucleoplasm] (Saccharomyces cerevisiae)

phospho-p-T68-CHEK2 [nucleoplasm] (Schizosaccharomyces pombe)

phospho-CHEK2 [nucleoplasm] (Bos taurus)

phospho-CHEK2 [nucleoplasm] (Canis familiaris)

phospho-CHEK2 [nucleoplasm] (Sus scrofa)

phospho-chek2 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-threonine at 68

Coordinate

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_009125.1, XP_011528147.1, XP_016884050.1, NP_001244316.1, NP_001005735.1, NP_665861.1

ZINC - World Drugs

CHK2_HUMAN

Guide to Pharmacology - Targets

1988

OpenTargets

ENSG00000183765

ZINC - FDA approved

CHK2_HUMAN

ZINC - Substances

CHK2_HUMAN

ZINC target

O96017

ZINC - Biogenic

CHK2_HUMAN

PRO

O96017

PDB

2CN5, 4A9T, 4BDG, 2YCR, 2XM9, 4BDH, 2XM8, 2WTC, 2YCQ, 2XK9, 4BDA, 2YIR, 2YIQ, 4BDF, 2CN8, 2WTJ, 2W7X, 2WTI, 2YCS, 4A9U, 2WTD, 4BDK, 4BDD, 2YIT, 4BDB, 2W0J, 4BDE, 3I6W, 3VA4, 4BDI, 4A9S, 2XBJ, 4A9R, 4BDJ, 1GXC, 2YCF, 3I6U, 4BDC

ZINC - Investigational

CHK2_HUMAN

IntEnz

2.7.11.1

GeneCards

O96017

HPA

ENSG00000183765-CHEK2

Ensembl

ENST00000404276, ENST00000650281, ENST00000405598, ENST00000417588, ENST00000403642, ENSP00000329012, ENST00000348295, ENSP00000372023, ENST00000448511, ENSP00000404400, ENSP00000390244, ENST00000382580, ENST00000425190, ENSP00000497000, ENSP00000404567, ENSP00000386087, ENSP00000385747, ENST00000649563, ENST00000433728, ENSG00000183765, ENSP00000384919, ENSP00000412901, ENSP00000496928

Pharos - Targets

O96017

Orphanet

15444

ZINC - Predictions - Purchasable

CHK2_HUMAN

HMDB Protein

HMDBP01248

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P52292 KPNA2	2	KPNA2 [nucleoplasm] (R-HSA-206045) KPNA2 [cytosol] (R-HSA-205976)	0.733	7
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603)	0.72	7
UniProt:O96017 CHEK2	3	p-T68-CHEK2 [nucleoplasm] (R-HSA-113825) CHEK2 [nucleoplasm] (R-HSA-113824) p-S,3T-CHEK2 [nucleoplasm] (R-HSA-5683784)	0.719	6
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.66	6
UniProt:Q15172 PPP2R5A	2	p-S28-PPP2R5A [cytosol] (R-HSA-9836658) PPP2R5A [cytosol] (R-HSA-196235)	0.658	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.646	3
UniProt:P18887 XRCC1	1	XRCC1 [nucleoplasm] (R-HSA-67455)	0.645	8
UniProt:Q13362-3 PPP2R5C			0.633	4
UniProt:P30304 CDC25A	6	PolyUb-CDC25A [cytosol] (R-HSA-6782810) CDC25A [nucleoplasm] (R-HSA-143487) CDC25A [cytosol] (R-HSA-157410) p-S124-CDC25A [nucleoplasm] (R-HSA-143488) p-S124-CDC25A [cytosol] (R-HSA-69588) p-S40,S116,S261-CDC25A [nucleoplasm] (R-HSA-8863634)	0.623	2
UniProt:Q9NY61 AATF	1	AATF [cytosol] (R-HSA-205071)	0.602	4
UniProt:Q13362-1 PPP2R5C			0.602	3
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.602	3
UniProt:Q93009 USP7	2	USP7 [cytosol] (R-HSA-8853511) USP7 [nucleoplasm] (R-HSA-3215278)	0.59	2
UniProt:O15355 PPM1G			0.564	2
UniProt:P27958-PRO_0000037577			0.556	3
UniProt:Q96KN1 LRAT2			0.543	3
UniProt:Q9UQ88-1 CDK11A			0.524	2
UniProt:P55072 VCP	8	Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) VCP [nucleoplasm] (R-HSA-5643745) VCP [secretory granule lumen] (R-HSA-6801039) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [extracellular region] (R-HSA-6806191) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [cytosol] (R-HSA-1181251)	0.524	2
UniProt:Q5VTR2 RNF20	2	RNF20 [cytosol] (R-HSA-9715141) RNF20 [nucleoplasm] (R-HSA-5689011)	0.508	3
UniProt:Q15173 PPP2R5B	2	p-S368-PPP2R5B [cytosol] (R-HSA-6811453) PPP2R5B [cytosol] (R-HSA-535469)	0.508	2
UniProt:Q13362-2 PPP2R5C			0.508	2
UniProt:Q16537 PPP2R5E	1	PPP2R5E [cytosol] (R-HSA-1638770)	0.508	3
UniProt:P0C6X7-PRO_0000037319 REP			0.508	2
UniProt:Q13007 IL24	1	IL24 [extracellular region] (R-HSA-448438)	0.508	3
UniProt:Q9Y248 GINS2	1	GINS2 [nucleoplasm] (R-HSA-176975)	0.499	2
UniProt:P56645 PER3			0.499	2
UniProt:P06725 UL83	1	CMVPP65 [viral tegument] (R-HCY-5685583)	0.499	2

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