Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CCND1 [nucleoplasm]
Stable Identifier
R-HSA-113832
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
G1/S-specific cyclin D1, PRAD1 oncogene, BCL-1 oncogene
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1 Phase (Homo sapiens)
Cyclin D associated events in G1 (Homo sapiens)
CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Homo sapiens)
CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
CDK4,CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
CDK4/6:CCND [nucleoplasm] (Homo sapiens)
Cyclin D [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
CDK4:CCND [nucleoplasm] (Homo sapiens)
CDK4:CCND1 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
CDK6:CCND [nucleoplasm] (Homo sapiens)
Cyclin D1:Cdk6 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
Cyclin D:CDK4,CDK6:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
Cyclin D [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
Cyclin D [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
Cyclin D [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
p-T172-CDK4:CCND [nucleoplasm] (Homo sapiens)
p-T172-CDK4:CCND1 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND1 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
Cyclin D [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
Cyclin D [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
p-T172-CDK4:CCND [nucleoplasm] (Homo sapiens)
p-T172-CDK4:CCND1 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND1 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
Cyclin D [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
Cyclin D [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
p-T172-CDK4:CCND [nucleoplasm] (Homo sapiens)
p-T172-CDK4:CCND1 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND1 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Homo sapiens)
p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Homo sapiens)
p-T172-CDK4:CCND1 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND:CDK6 inhibitors [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND1:CDK6 inhibitors (CCND1) [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND1 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
Cyclin D [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
Cyclin D [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
p-T172-CDK4:CCND [nucleoplasm] (Homo sapiens)
p-T172-CDK4:CCND1 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND1 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
Drug-mediated inhibition of CDK4/CDK6 activity (Homo sapiens)
CDK4 inhibitors bind CDK4 (Homo sapiens)
p-T172-CDK4:CCND [nucleoplasm] (Homo sapiens)
p-T172-CDK4:CCND1 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Homo sapiens)
p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Homo sapiens)
p-T172-CDK4:CCND1 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
CDK6 inhibitors bind CDK6 (Homo sapiens)
p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND1 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND:CDK6 inhibitors [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND1:CDK6 inhibitors (CCND1) [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND1 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
Cyclin D [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
Cyclin D [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
Cyclin D [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
p-T172-CDK4:CCND [nucleoplasm] (Homo sapiens)
p-T172-CDK4:CCND1 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND1 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Homo sapiens)
CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
CDK4,CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
CDK4/6:CCND [nucleoplasm] (Homo sapiens)
Cyclin D [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
CDK4:CCND [nucleoplasm] (Homo sapiens)
CDK4:CCND1 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
CDK6:CCND [nucleoplasm] (Homo sapiens)
Cyclin D1:Cdk6 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
Cyclin D:CDK4,CDK6:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
Cyclin D [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Ubiquitin-dependent degradation of Cyclin D (Homo sapiens)
Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta (Homo sapiens)
CDK4:CCND1 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
RMTs methylate histone arginines (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Homo sapiens)
CCND1:CDK4:PRMT5:WDR77 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77:COPRS [nucleoplasm] (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77:COPRS [nucleoplasm] (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77:COPRS [nucleoplasm] (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of mitotic cell cycle (Homo sapiens)
Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects (Homo sapiens)
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) (Homo sapiens)
Defective RB1 does not bind E2F1,(E2F2,E2F3) (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
Cyclin D [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
Cyclin D [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
Cyclin D [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
p-T172-CDK4:CCND [nucleoplasm] (Homo sapiens)
p-T172-CDK4:CCND1 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND1 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
Regulation of RUNX1 Expression and Activity (Homo sapiens)
CBFB binds RUNX1 (Homo sapiens)
CCND3,(CCND1,CCND2) [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
RUNX1:CCND3,(CCND1,CCND2) [nucleoplasm] (Homo sapiens)
CCND3,(CCND1,CCND2) [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
CCND3,(CCND1,CCND2) binds RUNX1 (Homo sapiens)
CCND3,(CCND1,CCND2) [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
RUNX1:CCND3,(CCND1,CCND2) [nucleoplasm] (Homo sapiens)
CCND3,(CCND1,CCND2) [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
CDK4 phosphorylates RUNX2 (Homo sapiens)
CDK4:CCND1 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
RUNX3 regulates p14-ARF (Homo sapiens)
CCND1 binds RUNX3 and displaces EP300 (Homo sapiens)
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
CCND1 recruits HDAC4 to RUNX3 (Homo sapiens)
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 [nucleoplasm] (Homo sapiens)
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
HDAC4 deacetylates RUNX3 (Homo sapiens)
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 [nucleoplasm] (Homo sapiens)
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
RUNX3:CBFB:CCND1:HDAC4 [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of STAT3-upregulated nuclear proteins (Homo sapiens)
STAT3-upregulated nuclear proteins [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Pre-NOTCH Expression and Processing (Homo sapiens)
Pre-NOTCH Transcription and Translation (Homo sapiens)
CCND1:CREBBP binds NOTCH1 promoter (Homo sapiens)
CCND1:CREBBP [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
CCND1:CREBBP:NOTCH1 Gene [nucleoplasm] (Homo sapiens)
CCND1:CREBBP [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
NOTCH1 gene transcription (Homo sapiens)
CCND1:CREBBP [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
CCND1:CREBBP:NOTCH1 Gene [nucleoplasm] (Homo sapiens)
CCND1:CREBBP [nucleoplasm] (Homo sapiens)
CCND1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P24385 CCND1
Gene Names
CCND1, BCL1, PRAD1
Chain
chain:1-295
Reference Genes
BioGPS Gene:595 CCND1
COSMIC (genes):CCND1 CCND1
CTD Gene:595 CCND1
dbSNP Gene:595 CCND1
ENSEMBL:ENSG00000110092 CCND1
ENSEMBL_homo_sapiens_GENE:ENSG00000110092.4 CCND1
HGNC:1582 CCND1
KEGG Gene (Homo sapiens):595 CCND1
Monarch:595 CCND1
NCBI Gene:595 CCND1
OMIM:168461 CCND1
Reference Transcript
RefSeq:NM_053056.2 CCND1
Other Identifiers
11721255_at
11721256_a_at
11721257_at
11751330_a_at
16728261
2017_s_at
2020_at
208711_PM_s_at
208711_s_at
208712_3p_at
208712_PM_at
208712_at
3338194
3338195
3338196
3338204
3338205
3338207
3338211
3338212
3338213
3338214
3338215
3338216
38418_at
595
7942123
A_14_P117958
A_23_P202837
A_24_P124550
A_24_P193011
GO:0000082
GO:0000122
GO:0000278
GO:0000307
GO:0000320
GO:0001934
GO:0003714
GO:0003824
GO:0004672
GO:0005515
GO:0005634
GO:0005635
GO:0005654
GO:0005737
GO:0005829
GO:0005923
GO:0006351
GO:0006355
GO:0006974
GO:0007049
GO:0007595
GO:0008283
GO:0009410
GO:0010971
GO:0012501
GO:0016020
GO:0016055
GO:0016301
GO:0016538
GO:0016740
GO:0017053
GO:0019899
GO:0019901
GO:0023052
GO:0030154
GO:0030182
GO:0030857
GO:0030968
GO:0031571
GO:0031965
GO:0033598
GO:0033601
GO:0036211
GO:0042826
GO:0043226
GO:0043524
GO:0044321
GO:0044772
GO:0045444
GO:0045737
GO:0048856
GO:0051301
GO:0051726
GO:0060749
GO:0061575
GO:0070064
GO:0070141
GO:0071310
GO:0097128
GO:0097421
GO:0098772
GO:0140096
GO:0140110
GO:2000045
HMNXSV003049250
ILMN_1688480
PH_hs_0024184
TC11000718.hg
X59798_at
g12652656_3p_s_at
g179364_3p_at
g179364_3p_x_at
Participates
as a member of
STAT3-upregulated nuclear proteins [nucleoplasm] (Homo sapiens)
Cyclin D [nucleoplasm] (Homo sapiens)
as a component of
CCND1:CDK4:PRMT5:WDR77 [nucleoplasm] (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
RUNX3:CBFB:CCND1:HDAC4 [nucleoplasm] (Homo sapiens)
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1 [nucleoplasm] (Homo sapiens)
CCND1:CREBBP [nucleoplasm] (Homo sapiens)
CDK4:CCND1 [nucleoplasm] (Homo sapiens)
Cyclin D1:Cdk6 [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND1 [nucleoplasm] (Homo sapiens)
p-T172-CDK4:CCND1 [nucleoplasm] (Homo sapiens)
as a candidate of
CCND3,(CCND1,CCND2) [nucleoplasm] (Homo sapiens)
as an input of
CCND1 binds RUNX3 and displaces EP300 (Homo sapiens)
Other forms of this molecule
CCND1 [cytosol]
p-T286-CCND1 [nucleoplasm]
p-T286-CCND1 [cytosol]
Inferred To
Ccnd1 [nucleoplasm]
(Mus musculus)
Ccnd1 [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of CCND1 [nucleoplasm]
(Dictyostelium discoideum)
CycD [nucleoplasm]
(Drosophila melanogaster)
CCND1 [nucleoplasm]
(Bos taurus)
CCND1 [nucleoplasm]
(Canis familiaris)
CCND1 [nucleoplasm]
(Gallus gallus)
CCND1 [nucleoplasm]
(Sus scrofa)
ccnd1 [nucleoplasm]
(Danio rerio)
ccnd1 [nucleoplasm]
(Xenopus tropicalis)
crs1 [nucleoplasm]
(Schizosaccharomyces pombe)
cyd-1 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_444284.1
OpenTargets
ENSG00000110092
GeneCards
P24385
HPA
ENSG00000110092-CCND1
Ensembl
ENST00000227507
,
ENSG00000110092
,
ENSP00000227507
PRO
P24385
Pharos - Targets
P24385
Orphanet
15408
HMDB Protein
HMDBP02156
PDB
2W9F
,
2W99
,
5VZU
,
6P8G
,
2W9Z
,
6P8E
,
2W96
,
6P8F
,
6P8H
Interactors (24)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11802 CDK4
3
CDK4 [cytosol]
(R-HSA-68330)
CDK4 [nucleoplasm]
(R-HSA-113843)
p-T172-CDK4 [nucleoplasm]
(R-HSA-113830)
0.985
45
UniProt:P38936 CDKN1A
5
p-T145-CDKN1A [cytosol]
(R-HSA-198614)
p-Y77-CDKN1A [cytosol]
(R-HSA-8942601)
CDKN1A [cytosol]
(R-HSA-182512)
CDKN1A [nucleoplasm]
(R-HSA-182585)
p-S130-CDKN1A [nucleoplasm]
(R-HSA-187857)
0.962
25
UniProt:P46527 CDKN1B
8
p-S10 CDKN1B [cytosol]
(R-HSA-9632829)
p-S10 CDKN1B [nucleoplasm]
(R-HSA-9632832)
p-T157-CDKN1B [cytosol]
(R-HSA-198629)
CDKN1B [cytosol]
(R-HSA-198622)
p-Y88-CDKN1B [cytosol]
(R-HSA-8848438)
p-Y88-CDKN1B [nucleoplasm]
(R-HSA-8942808)
p-T187-CDKN1B [nucleoplasm]
(R-HSA-187525)
CDKN1B [nucleoplasm]
(R-HSA-182563)
0.905
12
UniProt:P24941 CDK2
5
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
CDK2 [cytosol]
(R-HSA-157440)
CDK2 [nucleoplasm]
(R-HSA-68365)
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
0.845
8
UniProt:Q00534 CDK6
3
CDK6 [cytosol]
(R-HSA-68336)
CDK6 [nucleoplasm]
(R-HSA-141283)
p-T177-CDK6 [nucleoplasm]
(R-HSA-69628)
0.839
7
IntAct:EBI-4399559 UBIQ
0.743
4
UniProt:P06400 RB1
20
RB1 R661W [nucleoplasm]
(R-HSA-9659801)
RB1 C706F [nucleoplasm]
(R-HSA-9659812)
RB1 N480del [nucleoplasm]
(R-HSA-9659792)
RB1 C706Y [nucleoplasm]
(R-HSA-9659821)
RB1 R661Q [nucleoplasm]
(R-HSA-9659807)
RB1 I703_E737del [nucleoplasm]
(R-HSA-9661065)
RB1 R830_G887del [cytosol]
(R-HSA-9661059)
RB1 K791* [cytosol]
(R-HSA-9662284)
RB1 Q176* [cytosol]
(R-HSA-9661774)
RB1 S114* [cytosol]
(R-HSA-9661775)
RB1 K765* [cytosol]
(R-HSA-9662281)
RB1 W99* [cytosol]
(R-HSA-9661769)
RB1 S149* [cytosol]
(R-HSA-9661770)
RB1 E166* [cytosol]
(R-HSA-9661767)
RB1 G100* [cytosol]
(R-HSA-9661763)
RB1 E125* [cytosol]
(R-HSA-9661784)
RB1 Q121* [cytosol]
(R-HSA-9661780)
RB1 E184* [cytosol]
(R-HSA-9661781)
RB1 E137* [cytosol]
(R-HSA-9661782)
RB1 K745* [cytosol]
(R-HSA-9662288)
0.73
5
UniProt:P06493 CDK1
11
CDK1 [endoplasmic reticulum membrane]
(R-HSA-264424)
p-Y4-CDK1 [cytosol]
(R-HSA-9836187)
p-T14,T161-CDK1 [nucleoplasm]
(R-HSA-170078)
p-T14-CDK1 [nucleoplasm]
(R-HSA-170045)
p-T14-CDK1 [cytosol]
(R-HSA-170064)
CDK1 [nucleoplasm]
(R-HSA-68889)
CDK1 [cytosol]
(R-HSA-170075)
p-T14,Y15,T161-CDK1 [cytosol]
(R-HSA-170071)
p-T161-CDK1 [cytosol]
(R-HSA-157415)
p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-HSA-170074)
p-T161-CDK1 [nucleoplasm]
(R-HSA-170066)
0.643
3
UniProt:Q00535 CDK5
4
CDK5 [nucleoplasm]
(R-HSA-8863586)
p-Y15,S159-CDK5 [nucleoplasm]
(R-HSA-6805249)
CDK5 [cytosol]
(R-HSA-180064)
p-Y15-CDK5 [cytosol]
(R-HSA-399809)
0.643
4
UniProt:Q96PU4 UHRF2
1
UHRF2 [nucleoplasm]
(R-HSA-976050)
0.602
4
UniProt:P12004 PCNA
5
monoSUMO1-K164,K254,K-PCNA [nucleoplasm]
(R-HSA-4615861)
K63polyUb-K164-PCNA [nucleoplasm]
(R-HSA-8943000)
ISG-K164,ISG-K168-PCNA [nucleoplasm]
(R-HSA-5653768)
MonoUb-K164-PCNA [nucleoplasm]
(R-HSA-5651986)
PCNA [nucleoplasm]
(R-HSA-68439)
0.59
2
UniProt:P59595 N
9
N [cytosol]
(R-COV-9683625)
p-S177-N [cytosol]
(R-COV-9683754)
ADPr-p-S177-N [cytosol]
(R-COV-9686058)
SUMO1-K62-ADPr-p-S177-N [cytosol]
(R-COV-9682916)
SUMO1-K62-ADPr-p-S177-N [viral capsid]
(R-COV-9685478)
SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9683641)
N [plasma membrane]
(R-COV-9683611)
SUMO1-K62-ADPr-p-S177-N [nucleolus]
(R-COV-9683730)
SUMO1-K62-ADPr-p-S177-N [plasma membrane]
(R-COV-9686063)
0.576
3
UniProt:Q5XUX0 FBXO31
1
FBXO31 [cytosol]
(R-HSA-8850911)
0.576
4
UniProt:Q96TE0 Q96TE0
0.556
3
UniProt:O15379 HDAC3
2
HDAC3 [nucleoplasm]
(R-HSA-442464)
Unfolded HDAC3 [cytosol]
(R-HSA-6813777)
0.544
3
UniProt:P10275 AR
4
PolyUb-AR [nucleoplasm]
(R-HSA-6782984)
monoSUMO1-K386,520-AR [nucleoplasm]
(R-HSA-4090320)
AR [nucleoplasm]
(R-HSA-446174)
AR [cytosol]
(R-HSA-5618082)
0.544
4
UniProt:P42773 CDKN2C
1
CDKN2C [cytosol]
(R-HSA-182572)
0.527
3
UniProt:Q07283 TCHH
2
TCHH [cornified envelope]
(R-HSA-8934848)
TCHH [cytosol]
(R-HSA-6810842)
0.527
2
UniProt:P49918 CDKN1C
3
p-Y91-CDKN1C [cytosol]
(R-HSA-8942606)
CDKN1C [cytosol]
(R-HSA-8941913)
CDKN1C [nucleoplasm]
(R-HSA-8948130)
0.527
3
UniProt:Q16656 NRF1
1
NRF1 [nucleoplasm]
(R-HSA-1592205)
0.508
2
UniProt:P30260 CDC27
2
CDC27 [nucleoplasm]
(R-HSA-174175)
CDC27 [cytosol]
(R-HSA-174073)
0.499
3
UniProt:P42771 CDKN2A
20
p16INK4A D84G [cytosol]
(R-HSA-9632461)
p16INK4A E88* [cytosol]
(R-HSA-9632588)
p16INK4A R87P [cytosol]
(R-HSA-9632335)
p16INK4A V126D [cytosol]
(R-HSA-9631055)
p16INK4A W110* [cytosol]
(R-HSA-9632585)
p16INK4A D84H [cytosol]
(R-HSA-9632489)
p16INK4A R80* [cytosol]
(R-HSA-9632586)
p16INK4A P114L [cytosol]
(R-HSA-9630916)
p16INK4A R58* [cytosol]
(R-HSA-9632582)
p16INK4A D84N [cytosol]
(R-HSA-9632483)
p16INK4A M53I [cytosol]
(R-HSA-9630911)
p16INK4A D84Y [cytosol]
(R-HSA-9632478)
p16INK4A G101W [cytosol]
(R-HSA-9631257)
p16INK4A P81L [cytosol]
(R-HSA-9632280)
p16INK4A A20P [cytosol]
(R-HSA-9630805)
p16INK4A D84V [cytosol]
(R-HSA-9632465)
p16INK4A P81T [cytosol]
(R-HSA-9632275)
p16INK4A P81H [cytosol]
(R-HSA-9632293)
p16INK4A D84A [cytosol]
(R-HSA-9632486)
p16INK4A P81R [cytosol]
(R-HSA-9632294)
0.491
2
UniProt:P38398 BRCA1
20
polySUMO2,3-BRCA1 [nucleoplasm]
(R-HSA-2997624)
monoSUMO1-K109-BRCA1 [nucleoplasm]
(R-HSA-2997644)
BRCA1 M1411T [nucleoplasm]
(R-HSA-9702140)
BRCA1 M1400V [nucleoplasm]
(R-HSA-9701202)
BRCA1 L1407P [nucleoplasm]
(R-HSA-9702135)
BRCA1 Y777* [nucleoplasm]
(R-HSA-9702765)
BRCA1 S1009* [nucleoplasm]
(R-HSA-9702755)
BRCA1 P724Lfs*12 [nucleoplasm]
(R-HSA-9703778)
BRCA1 S451* [nucleoplasm]
(R-HSA-9702754)
BRCA1 S864* [nucleoplasm]
(R-HSA-9702752)
BRCA1 P897Kfs*5 [nucleoplasm]
(R-HSA-9703782)
BRCA1 N555Kfs*17 [nucleoplasm]
(R-HSA-9703781)
BRCA1 Y1127Sfs*6 [nucleoplasm]
(R-HSA-9703780)
BRCA1 S886Cfs*16 [nucleoplasm]
(R-HSA-9703802)
BRCA1 V83Cfs*2 [nucleoplasm]
(R-HSA-9703800)
BRCA1 T464Pfs*11 [nucleoplasm]
(R-HSA-9703807)
BRCA1 G813Dfs*2 [nucleoplasm]
(R-HSA-9703549)
BRCA1 V340Gfs*6 [nucleoplasm]
(R-HSA-9703804)
BRCA1 Y655* [nucleoplasm]
(R-HSA-9702769)
BRCA1 W372* [nucleoplasm]
(R-HSA-9702768)
0.463
3
UniProt:Q13761 RUNX3
7
RUNX3 [nucleoplasm]
(R-HSA-8865393)
RUNX3 [cytosol]
(R-HSA-8937797)
Ac-K94,K171-RUNX3 [nucleoplasm]
(R-HSA-8951965)
PolyUb-K94,K148-RUNX3 [cytosol]
(R-HSA-8952400)
PolyUb-K94,K148-RUNX3 [nucleoplasm]
(R-HSA-8952387)
p-Y-RUNX3 [cytosol]
(R-HSA-8937805)
PolyUb-RUNX3 [nucleoplasm]
(R-HSA-8952417)
0.462
8
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text