Reactome | p-S317,S345-CHEK1 [nucleoplasm]

p-S317,S345-CHEK1 [nucleoplasm]

Stable Identifier

R-HSA-113838

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

phospho-Chk1, Serine/threonine-protein kinase Chk1 (EC 2.7.1.-) phosphorylated, Serine/threonine-protein kinase Chk1

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External Reference Information

External Reference

UniProt:O14757 CHEK1

Gene Names

CHEK1, CHK1

Chain

chain:1-476

Reference Genes

BioGPS Gene:1111 CHEK1

COSMIC (genes):CHEK1 CHEK1

CTD Gene:1111 CHEK1

dbSNP Gene:1111 CHEK1

ENSEMBL:ENSG00000149554 CHEK1

ENSEMBL_homo_sapiens_GENE:ENSG00000149554.15 CHEK1

HGNC:1925 CHEK1

KEGG Gene (Homo sapiens):1111 CHEK1

Monarch:1111 CHEK1

NCBI Gene:1111 CHEK1

OMIM:603078 CHEK1

UCSC:O14757 CHEK1

Reference Transcript

Other Identifiers

1111

11729663_a_at

11738250_at

11738251_x_at

11745948_a_at

11745949_x_at

11759013_at

16733104

205393_PM_s_at

205393_s_at

205394_PM_at

205394_at

238075_PM_at

238075_at

3354800

3354801

3354802

3354803

3354804

3354805

3354806

3354807

3354808

3354809

3354810

3354811

3354812

3354813

3354814

3354815

3354818

3354822

3354823

3354824

3354826

3354828

3354829

3354830

3354831

3354832

3354833

3354834

3354839

38920_at

50018_at

7945014

A_14_P109041

A_14_P137119

A_23_P116123

A_33_P3349536

GE62458

GO:0000077

GO:0000086

GO:0000166

GO:0000228

GO:0000278

GO:0000781

GO:0000785

GO:0000794

GO:0001833

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005657

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006260

GO:0006281

GO:0006310

GO:0006325

GO:0006338

GO:0006468

GO:0006915

GO:0006974

GO:0006997

GO:0007010

GO:0007049

GO:0007095

GO:0010468

GO:0010569

GO:0010972

GO:0012501

GO:0016301

GO:0016310

GO:0016740

GO:0018107

GO:0019904

GO:0023052

GO:0032991

GO:0035402

GO:0035556

GO:0036211

GO:0042127

GO:0042770

GO:0043226

GO:0043231

GO:0044818

GO:0045787

GO:0045814

GO:0045839

GO:0046602

GO:0048856

GO:0070317

GO:0071260

GO:0071310

GO:0071313

GO:0090399

GO:0106310

GO:0140014

GO:0140096

GO:1901796

GO:1902742

GO:2000279

HMNXSV003031264

HMNXSV003055633

Hs.24529.0.A1_3p_at

ILMN_1664630

PH_hs_0022049

TC11003470.hg

g4502802_3p_at

Participates

as an output of

This entity regulates

Negatively

Other forms of this molecule

CHEK1 [cytosol]

CHEK1 [nucleoplasm]

Inferred To

phospho-p-S317,S345-CHEK1 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-S317,S345-CHEK1 [nucleoplasm] (Canis familiaris)

phospho-p-S317,S345-CHEK1 [nucleoplasm] (Drosophila melanogaster)

phospho-p-S317,S345-CHEK1 [nucleoplasm] (Mus musculus)

phospho-p-S317,S345-CHEK1 [nucleoplasm] (Rattus norvegicus)

phospho-p-S317,S345-CHEK1 [nucleoplasm] (Saccharomyces cerevisiae)

phospho-p-S317,S345-CHEK1 [nucleoplasm] (Schizosaccharomyces pombe)

phospho-p-S317,S345-CHEK1 [nucleoplasm] (Sus scrofa)

Modified Residues

Name

O-phospho-L-serine at 317

Coordinate

317

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 345

Coordinate

345

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001107593.1, NP_001265.2, NP_001317357.1, NP_001231775.1, NP_001107594.1, XP_016872635.1

ZINC - World Drugs

CHK1_HUMAN

Guide to Pharmacology - Targets

1987

OpenTargets

ENSG00000149554

ZINC - FDA approved

CHK1_HUMAN

ZINC - Substances

CHK1_HUMAN

ZINC - Biogenic

CHK1_HUMAN

ZINC target

O14757

PRO

O14757

PDB

2WMT, 2YM4, 8SIV, 4FST, 4FTM, 7BKN, 2WMU, 2E9N, 2HXL, 2XF0, 2WMV, 7AKM, 5OQ5, 7BJJ, 6FC8, 2WMW, 3TKI, 7BJM, 2HOG, 2YDI, 4FSM, 1ZLT, 4FSZ, 2YEX, 5OPU, 5OOT, 4FTR, 2E9V, 4RVM, 7BJR, 4FSQ, 3NLB, 1NVQ, 4FTK, 7SUF, 4FTU, 7BK1, 7BJX, 5OPR, 2CGW, 4FT3, 5OP4, 2X8D, 2XEZ, 2CGX, 5OPB, 4FT9, 2GDO, 4FTC, 5OOR, 2X8I, 4HYI, 8E81, 2YM6, 5OQ6, 7BJE, 7MCK, 2C3K, 3OT3, 4QYE, 3F9N, 2CGV, 5DLS, 7BK3, 4FTQ, 2E9U, 7BJH, 5F4N, 2WMR, 4QYG, 5OP5, 2WMS, 2YDJ, 2YWP, 7BK2, 3JVR, 3U9N, 1ZYS, 7BJD, 3PA4, 2GHG, 4FTN, 1NVR, 3TKH, 1NVS, 2YM3, 1IA8, 2BRN, 4FSR, 4FTL, 4QYH, 2BRM, 2BR1, 2E9O, 2HXQ, 4FTO, 2BRO, 2E9P, 7AKO, 2HY0, 2C3J, 5OPS, 4RVK, 4FTT, 2R0U, 4FT0, 5OP2, 2YM8, 2YER, 4GH2, 2BRB, 4FSY, 2C3L, 2QHM, 8SIX, 2QHN, 6FCK, 5WI2, 2BRG, 4FSN, 4JIK, 4FTJ, 2BRH, 7BJO, 5OQ7, 2YM5, 7BKO, 2XEY, 2AYP, 5OQ8, 8SIW, 6FCF, 5OPV, 2YM7, 5OP7, 4FSW, 7SUJ, 8E80, 4FTA, 5OOP, 2X8E, 4FSU, 4HYH, 7SUH, 2WMX, 3PA3, 4FTI, 2WMQ, 2CGU, 7SUI, 3JVS, 4FT7, 3OT8, 3PA5, 4FT5, 4RVL, 7SUG, 2YDK, 4QYF

ZINC - Investigational

CHK1_HUMAN

GeneCards

O14757

HPA

ENSG00000149554-CHEK1

Ensembl

ENSP00000412504, ENSP00000278916, ENST00000532449, ENSP00000481616, ENSP00000432890, ENST00000428830, ENSP00000442317, ENST00000438015, ENSP00000435371, ENST00000544373, ENST00000524737, ENSP00000388648, ENSG00000149554, ENST00000278916, ENST00000534070

Pharos - Targets

O14757

ZINC - Predictions - Purchasable

CHK1_HUMAN

HMDB Protein

HMDBP01474

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.697	8
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.656	3
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.643	3
UniProt:P30307 CDC25C	8	p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol] (R-HSA-8863654) p-S191-CDC25C [nucleoplasm] (R-HSA-6802968) p-S216-CDC25C [cytosol] (R-HSA-75003) p-S216-CDC25C [nucleoplasm] (R-HSA-156496) CDC25C [nucleoplasm] (R-HSA-69741) CDC25C [cytosol] (R-HSA-157879) p-S198-CDC25C [cytosol] (R-HSA-8981697) p-S198-CDC25C [nucleoplasm] (R-HSA-156668)	0.623	2
UniProt:Q9HCE7-2 SMURF1			0.611	4
UniProt:Q9HAW4 CLSPN	5	PolyUb-CLSPN [nucleoplasm] (R-HSA-6783087) CLSPN(1-1072) [nucleoplasm] (R-HSA-351929) CLSPN(1073-1332) [nucleoplasm] (R-HSA-351935) CLSPN [nucleoplasm] (R-HSA-176282) p-T916,S945-CLSPN [nucleoplasm] (R-HSA-176296)	0.602	5
UniProt:Q30154 HLA-DRB5	9	HLA class II histocompatibility antigen, DR beta 5 chain [lumenal side of endoplasmic reticulum membrane] (R-HSA-2130361) HLA class II histocompatibility antigen, DR beta 5 chain [ER to Golgi transport vesicle membrane] (R-HSA-2130691) HLA class II histocompatibility antigen, DR beta 5 chain [Golgi membrane] (R-HSA-2214365) HLA class II histocompatibility antigen, DR beta 5 chain [trans-Golgi network membrane] (R-HSA-2130357) HLA class II histocompatibility antigen, DR beta 5 chain [transport vesicle membrane] (R-HSA-2130326) HLA class II histocompatibility antigen, DR beta 5 chain [clathrin-coated endocytic vesicle membrane] (R-HSA-2130548) HLA class II histocompatibility antigen, DR beta 5 chain [endocytic vesicle membrane] (R-HSA-2130382) HLA class II histocompatibility antigen, DR beta 5 chain [lysosomal membrane] (R-HSA-2130591) HLA class II histocompatibility antigen, DR beta 5 chain [plasma membrane] (R-HSA-1235083)	0.564	2
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.564	2
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.558	3
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.527	2
UniProt:Q15170 TCAL1			0.527	3
UniProt:O00165 HAX1			0.527	2
UniProt:O15496 PLA2G10	1	PLA2G10 [extracellular region] (R-HSA-1498793)	0.527	2
UniProt:Q86X45 DAA11			0.527	2
UniProt:Q9H0H5 RACGAP1	1	RACGAP1 [cytosol] (R-HSA-195122)	0.527	2
UniProt:Q2NKX8 ERCC6L	1	ERCC6L [cytosol] (R-HSA-376250)	0.527	2
UniProt:Q9UGM1 CHRNA9	1	CHRNA9 [plasma membrane] (R-HSA-507827)	0.527	2
UniProt:Q9BZR8 BCL2L14	1	BCL2L14 [cytosol] (R-HSA-6791317)	0.527	2
UniProt:Q14627 IL13RA2	1	IL13RA2 [extracellular region] (R-HSA-449666)	0.527	2
UniProt:Q06609 RAD51	2	RAD51 [nucleoplasm] (R-HSA-62637) p-T309-RAD51 [nucleoplasm] (R-HSA-5685231)	0.524	3
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.463	3

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