Reactome: A Curated Pathway Database

p-S317,S345-CHEK1

Stable Identifier
R-HSA-113838
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
phospho-Chk1, Serine/threonine-protein kinase Chk1 (EC 2.7.1.-) phosphorylated, Serine/threonine-protein kinase Chk1
Locations in the PathwayBrowser
External Reference Information
External Reference
Gene Names
CHEK1, CHK1
Chain
chain:1-476
Reference Genes
Reference Transcript
Other Identifiers
 1111  11729663_a_at  11738250_at  11738251_x_at  11745948_a_at
 11745949_x_at  11759013_at  16733104  1IA8  1NVQ
 1NVR  1NVS  1ZLT  1ZYS  205393_s_at
 205394_at  238075_at  2AYP  2BR1  2BRB
 2BRG  2BRH  2BRM  2BRN  2BRO
 2C3J  2C3K  2C3L  2CGU  2CGV
 2CGW  2CGX  2E9N  2E9O  2E9P
 2E9U  2E9V  2GDO  2GHG  2HOG
 2HXL  2HXQ  2HY0  2QHM  2QHN
 2R0U  2WMQ  2WMR  2WMS  2WMT
 2WMU  2WMV  2WMW  2WMX  2X8D
 2X8E  2X8I  2XEY  2XEZ  2XF0
 2YDI  2YDJ  2YDK  2YER  2YEX
 2YM3  2YM4  2YM5  2YM6  2YM7
 2YM8  2YWP  3354800  3354801  3354802
 3354803  3354804  3354805  3354806  3354807
 3354808  3354809  3354810  3354811  3354812
 3354813  3354814  3354815  3354818  3354822
 3354823  3354824  3354826  3354828  3354829
 3354830  3354831  3354832  3354833  3354834
 3354839  38920_at  3F9N  3JVR  3JVS
 3NLB  3OT3  3OT8  3PA3  3PA4
 3PA5  3TKH  3TKI  3U9N  44364
 4FSM  4FSN  4FSQ  4FSR  4FST
 4FSU  4FSW  4FSY  4FSZ  4FT0
 4FT3  4FT5  4FT7  4FT9  4FTA
 4FTC  4FTI  4FTJ  4FTK  4FTL
 4FTM  4FTN  4FTO  4FTQ  4FTR
 4FTT  4FTU  4GH2  4HYH  4HYI
 4JIK  4QYE  4QYF  4QYG  4QYH
 4RVK  4RVL  4RVM  50018_at  5DLS
 5F4N  7945014  A_14_P109041  A_23_P116123  A_33_P3349536
 AAB88852  AAC51736  AAH04202  AAH17575  AAM78553
 AB032387  AB451222  AB451345  AEB71796  AF016582
 AF032874  AF527555  AK292549  AK293143  AK299783
 AP001132  BAA84577  BAF85238  BAG56691  BAG61665
 BAG70036  BAG70159  BC004202  BC017575  CCDS58191
 CCDS81645  CCDS8459  CH471065  CHEK1  CHEK1-203
 CHEK1-204  CHEK1-206  CHEK1-213  CHEK1-216  CHEK1-218
 EAW67644  ENSG00000149554  ENSP00000388648  ENSP00000412504  ENSP00000432890
 ENSP00000435371  ENSP00000442317  ENSP00000481616  ENST00000428830  ENST00000438015
 ENST00000524737  ENST00000532449  ENST00000534070  ENST00000544373  EntrezGene:1111
 g4502802_3p_at  GO:0000077  GO:0000166  GO:0000228  GO:0000278
 GO:0000781  GO:0000785  GO:0000794  GO:0003674  GO:0004672
 GO:0004674  GO:0005515  GO:0005524  GO:0005575  GO:0005576
 GO:0005615  GO:0005622  GO:0005623  GO:0005634  GO:0005654
 GO:0005694  GO:0005737  GO:0005813  GO:0005815  GO:0005829
 GO:0005856  GO:0006259  GO:0006260  GO:0006281  GO:0006464
 GO:0006468  GO:0006950  GO:0006974  GO:0006975  GO:0007010
 GO:0007049  GO:0007165  GO:0007568  GO:0008150  GO:0009058
 GO:0010569  GO:0010767  GO:0016301  GO:0016310  GO:0016740
 GO:0018107  GO:0019904  GO:0031572  GO:0034641  GO:0035402
 GO:0035407  GO:0035556  GO:0043167  GO:0043226  GO:0043231
 GO:0043234  GO:0045787  GO:0045839  GO:0046602  GO:0048096
 GO:0051276  GO:0071260  GO:0090399  GO:0140014  GO:1901796
 GO:2000615  HGNC:1925  HPA044364  Hs.24529  Hs.24529.0.A1_3p_at
 ILMN_1664630  IPR000719  IPR008271  IPR011009  IPR017441
 JF289264  MIM:603078  NM_001114121  NM_001114122  NM_001244846
 NM_001274  NM_001330428  NP_001107593  NP_001107594  NP_001231775
 NP_001265  NP_001317357  NR_045204  NR_045205  PF00069
 PH_hs_0022049  SM00220  TC11003470.hg  uc001qcf.5  uc001qcg.5
 uc009zbo.4  uc010sbi.3  uc058ivr.1  uc058ivx.1  UPI000013DBA3
 UPI00001FA642  UPI0002064EAC  XM_011542562  XM_011542563  XM_017017146
 XP_011540864  XP_016872635
Participant Of
This entity regulates
Other forms of this molecule
Inferred To
Modified Residues
Name Coordinate Modification PsiMod
O-phospho-L-serine at 317 317
O-phospho-L-serine [MOD:00046] A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
O-phospho-L-serine at 345 345
O-phospho-L-serine [MOD:00046] A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
ZINC - World Drugs
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
UCSC human
GeneCards
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors
Confidence Score Interactor Accession Interactor Name Evidence (IntAct)
0.656 P08238 HS90B_HUMAN 3
0.623 P30307 MPIP3_HUMAN 2
0.611 Q9HCE7-2 SMURF1 4
0.602 P61981 1433G_HUMAN 7
0.602 Q9HAW4 CLSPN_HUMAN 5
0.558 P06400 RB_HUMAN 3
0.524 Q06609 RAD51_HUMAN 3
0.499 Q95KV1 IKKA_BOVIN 3
0.463 P38398 BRCA1_HUMAN 3