CDK4

Stable Identifier
R-HSA-113843
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cdk4, Cell division protein kinase 4 (EC 2.7.1.- ) (Cyclin-dependent kinase 4) (PSK-J3) (CDK4), Cell division protein kinase 4 , Cyclin-dependent kinase 4, PSK-J3
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:P11802 CDK4
Gene Names
CDK4
Chain
initiator methionine:1, chain:2-303
Reference Genes
BioGPS Gene:1019 CDK4
COSMIC (genes):CDK4 CDK4
CTD Gene:1019 CDK4
dbSNP Gene:1019 CDK4
ENSEMBL:ENSG00000135446 CDK4
ENSEMBL:ENSG00000135446 CDK4
HGNC:1773 CDK4
KEGG Gene (Homo sapiens):hsa:1019 CDK4
Monarch:1019 CDK4
NCBI Gene:1019 CDK4
OMIM:123829 CDK4
UCSC:P11802 CDK4
Reference Transcript
Other Identifiers
0007040008
0007040292
1019
11722561_a_at
11722562_s_at
11750512_x_at
11753378_a_at
13116
16766683
1942_s_at
1LD2
202246_s_at
2W96
2W99
2W9F
2W9Z
3458784
3458785
3458786
3458790
3458791
3458793
3458799
3458801
3458802
3458803
3458805
3458809
3458810
3458811
3G33
5FWK
5FWL
5FWM
5FWP
6024
69405
7964522
A0A024RBB6
A_23_P24997
AAA35673
AAC39521
AAC50506
AAD13991
AAH03644
AAH05864
AAH10153
AAM23014
AC025165
AF507942
AK297901
AK313701
BAG36447
BAG60221
BC003644
BC005864
BC010153
CAA88834
CAB069405
CAG28596
CAG47043
CCDS8953
CDK4
CDK4-201
CH471054
CR407668
CR542247
EAW97058
EAW97060
ENSG00000135446
ENSP00000257904
ENST00000257904
EntrezGene:1019
g4502734_3p_s_at
GE57828
GE59111
GO:0000082
GO:0000166
GO:0000278
GO:0000307
GO:0000785
GO:0002088
GO:0003674
GO:0004672
GO:0004674
GO:0004693
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005635
GO:0005654
GO:0005667
GO:0005694
GO:0005730
GO:0005737
GO:0005829
GO:0005923
GO:0006367
GO:0006412
GO:0006464
GO:0006468
GO:0006629
GO:0006950
GO:0007049
GO:0007165
GO:0007275
GO:0007623
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0009056
GO:0009058
GO:0009636
GO:0010033
GO:0010288
GO:0010468
GO:0010971
GO:0016020
GO:0016301
GO:0016310
GO:0016538
GO:0016740
GO:0030234
GO:0030332
GO:0031100
GO:0031658
GO:0031965
GO:0032869
GO:0033574
GO:0034641
GO:0040007
GO:0040014
GO:0042127
GO:0042493
GO:0043065
GO:0043167
GO:0043226
GO:0043234
GO:0045727
GO:0045787
GO:0045793
GO:0046626
GO:0046890
GO:0048146
GO:0048471
GO:0048856
GO:0050994
GO:0051301
GO:0051726
GO:0055093
GO:0060612
GO:0071157
GO:0071222
GO:0071353
GO:0097129
GO:1904628
GO:1904637
HGNC:1773
HPA006024
ILMN_1689001
IPR000719
IPR008271
IPR011009
IPR017441
LRG_490
M14505
MIM:123829
MIM:609048
NM_000075
NP_000066
PF00069
PH_hs_0005210
PH_hs_0035491
Q96BE9
S67448
SM00220
TC12001633.hg
U37022
U37022_rna1_at
U81031
uc001spv.4
UPI0000113582
Z48970
Participant Of
hasMember
input
output
hasComponent
This entity regulates
Positive Regulation
Other forms of this molecule
p-T172-CDK4 [nucleoplasm]
CDK4 [cytosol]
Inferred To
Homologues of CDK4 [nucleoplasm] (Bos taurus)
Homologues of CDK4 [nucleoplasm] (Danio rerio)
Homologues of CDK4 [nucleoplasm] (Drosophila melanogaster)
Homologues of CDK4 [nucleoplasm] (Xenopus tropicalis)
CDK4 [nucleoplasm] (Bos taurus)
CDK4 [nucleoplasm] (Canis familiaris)
CDK4 [nucleoplasm] (Danio rerio)
CDK4 [nucleoplasm] (Drosophila melanogaster)
CDK4 [nucleoplasm] (Mus musculus)
CDK4 [nucleoplasm] (Rattus norvegicus)
CDK4 [nucleoplasm] (Saccharomyces cerevisiae)
CDK4 [nucleoplasm] (Sus scrofa)
CDK4 [nucleoplasm] (Xenopus tropicalis)
Cross References
RefSeq
ZINC - World Drugs
ZINC - FDA approved
ZINC - Substances
GeneCards
DOCK Blaster
ZINC target
PRO
BRENDA (Homo sapiens)
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
PDB
Interactors (24)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P24385 CCND1  4 0.977 29
 UniProt:P30281 CCND3  2 0.975 27
 UniProt:P42773 CDKN2C  1 0.957 19
 UniProt:P42772 CDKN2B  1 0.953 15
 UniProt:P42771 CDKN2A  1 0.944 14
 UniProt:P55273 CDKN2D  1 0.927 18
 UniProt:Q16543 CDC37  1 0.89 12
 UniProt:P46527 CDKN1B  6 0.87 6
 UniProt:P30279 CCND2  2 0.859 12
 UniProt:Q9UJC3 HOOK1      0.805 11
 UniProt:P38936 CDKN1A  5 0.8 5
 UniProt:Q8N720 ZNF655  1 0.683 5
 UniProt:P08238 HSP90AB1  5 0.641 3
 UniProt:P01106 MYC  2 0.592 2
 UniProt:P46379 BAG6      0.573 2
 UniProt:Q8IZT6 ASPM      0.564 2
 UniProt:Q15047 SETDB1  1 0.553 2
 UniProt:Q16254 E2F4  1 0.534 2
 UniProt:Q14004 CDK13  3 0.527 2
 UniProt:Q96D03 DDT4L      0.488 2
 UniProt:Q0VD86 INCA1      0.488 2
 UniProt:Q9ULD0 OGDHL      0.488 2
 UniProt:Q9UKT9 IKZF3      0.488 4
 UniProt:Q8N448 LNX2      0.488 2