Reactome | CDK4 [nucleoplasm]

CDK4 [nucleoplasm]

Stable Identifier

R-HSA-113843

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Cdk4, Cell division protein kinase 4 (EC 2.7.1.- ) (Cyclin-dependent kinase 4) (PSK-J3) (CDK4), Cell division protein kinase 4 , Cyclin-dependent kinase 4, PSK-J3

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P11802 CDK4

Gene Names

CDK4

Chain

initiator methionine:1, chain:2-303

Reference Genes

BioGPS Gene:1019 CDK4

COSMIC (genes):CDK4 CDK4

CTD Gene:1019 CDK4

dbSNP Gene:1019 CDK4

ENSEMBL:ENSG00000135446 CDK4

HGNC:1773 CDK4

KEGG Gene (Homo sapiens):1019 CDK4

Monarch:1019 CDK4

NCBI Gene:1019 CDK4

OMIM:123829 CDK4

UCSC:P11802 CDK4

Reference Transcript

RefSeq:NM_000075.3 CDK4

Other Identifiers

0007040008

0007040292

1019

11722561_a_at

11722562_s_at

11750512_x_at

11753378_a_at

16766683

1942_s_at

202246_s_at

3458784

3458785

3458786

3458790

3458791

3458793

3458799

3458801

3458802

3458803

3458805

3458809

3458810

3458811

7964522

A_23_P24997

GE57828

GE59111

GO:0000079

GO:0000082

GO:0000166

GO:0000278

GO:0000307

GO:0000785

GO:0002088

GO:0003674

GO:0004672

GO:0004674

GO:0004693

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005635

GO:0005654

GO:0005667

GO:0005694

GO:0005730

GO:0005737

GO:0005829

GO:0005923

GO:0006367

GO:0006412

GO:0006464

GO:0006468

GO:0006629

GO:0006950

GO:0007049

GO:0007165

GO:0007623

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0008353

GO:0009056

GO:0009058

GO:0009636

GO:0010033

GO:0010288

GO:0010468

GO:0010971

GO:0016020

GO:0016301

GO:0016310

GO:0016538

GO:0016592

GO:0016740

GO:0030234

GO:0030332

GO:0031100

GO:0031965

GO:0032869

GO:0032991

GO:0033574

GO:0034641

GO:0040007

GO:0040014

GO:0042127

GO:0042493

GO:0043065

GO:0043167

GO:0043226

GO:0044877

GO:0045727

GO:0045787

GO:0045793

GO:0046626

GO:0046890

GO:0048146

GO:0048471

GO:0048856

GO:0050994

GO:0051301

GO:0051726

GO:0055093

GO:0060612

GO:0071157

GO:0071222

GO:0071353

GO:0097129

GO:1904628

GO:1904637

GO:2000134

ILMN_1689001

PH_hs_0005210

PH_hs_0035491

TC12001633.hg

U37022_rna1_at

g4502734_3p_s_at

Participant Of

hasComponent

input

output

Resolution of meiotic holliday junction

hasMember

CDK4,CDK6 [nucleoplasm]

This entity regulates

Positively

Expression of FABP4 (aP2)

Other forms of this molecule

p-T172-CDK4 [nucleoplasm]

CDK4 [cytosol]

Inferred To

cdk8 [nucleoplasm] (Dictyostelium discoideum)

Homologues of CDK4 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of CDK4 [nucleoplasm] (Schizosaccharomyces pombe)

SSN3 [nucleoplasm] (Saccharomyces cerevisiae)

YGK3 [nucleoplasm] (Saccharomyces cerevisiae)

CAK1 [nucleoplasm] (Saccharomyces cerevisiae)

cdk4 [nucleoplasm] (Danio rerio)

srb10 [nucleoplasm] (Schizosaccharomyces pombe)

Cdk4 [nucleoplasm] (Drosophila melanogaster)

Cdk4 [nucleoplasm] (Mus musculus)

Cdk4 [nucleoplasm] (Rattus norvegicus)

CDK4 [nucleoplasm] (Bos taurus)

CDK4 [nucleoplasm] (Canis familiaris)

CDK4 [nucleoplasm] (Plasmodium falciparum)

CDK4 [nucleoplasm] (Sus scrofa)

CDK4 [nucleoplasm] (Xenopus tropicalis)

cdk-4 [nucleoplasm] (Caenorhabditis elegans)

csk1 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_000066.1

ZINC - World Drugs

CDK4_HUMAN

OpenTargets

ENSG00000135446

ZINC - FDA approved

CDK4_HUMAN

ZINC - Substances

CDK4_HUMAN

ZINC - Biogenic

CDK4_HUMAN

ZINC target

P11802

PRO

P11802

PDB

6P8F, 5FWM, 2W9Z, 2W96, 6P8G, 2W9F, 6P8H, 5FWK, 6P8E, 5FWP, 1LD2, 2W99, 5FWL, 3G33

ZINC - Investigational

CDK4_HUMAN

HPA

ENSG00000135446-CDK4

GeneCards

P11802

Ensembl

ENSP00000257904, ENSG00000135446, ENST00000257904

ZINC - Predictions - Purchasable

CDK4_HUMAN

Orphanet

15422

HMDB Protein

HMDBP01403

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P24385 CCND1	4	CCND1 [cytosol] (R-HSA-68328) CCND1 [nucleoplasm] (R-HSA-113832) p-T286-CCND1 [cytosol] (R-HSA-75813) p-T286-CCND1 [nucleoplasm] (R-HSA-75811)	0.982	38
UniProt:P30281 CCND3	2	CCND3 [cytosol] (R-HSA-68333) CCND3 [nucleoplasm] (R-HSA-113835)	0.978	35
UniProt:P42773 CDKN2C	1	CDKN2C [cytosol] (R-HSA-182572)	0.967	24
UniProt:P42772 CDKN2B	1	CDKN2B [cytosol] (R-HSA-182586)	0.964	19
UniProt:P55273 CDKN2D	1	CDKN2D [cytosol] (R-HSA-182580)	0.961	24
UniProt:P42771 CDKN2A	80	p16INK4A E88* [cytosol] (R-HSA-9632588) p16INK4A D84G [cytosol] (R-HSA-9632461) p16INK4A R87P [cytosol] (R-HSA-9632335) p16INK4A V126D [cytosol] (R-HSA-9631055) p16INK4A W110* [cytosol] (R-HSA-9632585) p16INK4A D84H [cytosol] (R-HSA-9632489) p16INK4A R80* [cytosol] (R-HSA-9632586) p16INK4A P114L [cytosol] (R-HSA-9630916) p16INK4A R58* [cytosol] (R-HSA-9632582) p16INK4A D84N [cytosol] (R-HSA-9632483) p16INK4A M53I [cytosol] (R-HSA-9630911) p16INK4A D84Y [cytosol] (R-HSA-9632478) p16INK4A G101W [cytosol] (R-HSA-9631257) p16INK4A P81L [cytosol] (R-HSA-9632280) p16INK4A A20P [cytosol] (R-HSA-9630805) p16INK4A D84V [cytosol] (R-HSA-9632465) p16INK4A P81T [cytosol] (R-HSA-9632275) p16INK4A P81H [cytosol] (R-HSA-9632293) p16INK4A D84A [cytosol] (R-HSA-9632486) p16INK4A P81R [cytosol] (R-HSA-9632294) p16INK4A E10* [cytosol] (R-HSA-9648382) p16INK4A S12* [cytosol] (R-HSA-9648383) p16INK4A P114T [cytosol] (R-HSA-9631034) p16INK4A P114S [cytosol] (R-HSA-9631027) p16INK4A G23fs3 [cytosol] (R-HSA-9648652) p16INK4A E61 [cytosol] (R-HSA-9648396) p16INK4A A20T [cytosol] (R-HSA-9630861) p16INK4A A36fs17 [cytosol] (R-HSA-9648653) p16INK4A E69 [cytosol] (R-HSA-9648397) p16INK4A W15fs1 [cytosol] (R-HSA-9648654) p16INK4A Y44 [cytosol] (R-HSA-9648398) p16INK4A T18fs15 [cytosol] (R-HSA-9648655) p16INK4A E26 [cytosol] (R-HSA-9648392) p16INK4A E33* [cytosol] (R-HSA-9648393) p16INK4A Q50* [cytosol] (R-HSA-9648394) p16INK4A E120* [cytosol] (R-HSA-9632587) p16INK4A S7fs8 [cytosol] (R-HSA-9648651) p16INK4A W15 [cytosol] (R-HSA-9648395) p16INK4A P75* [cytosol] (R-HSA-9648388) p16INK4A C72* [cytosol] (R-HSA-9648389) p16INK4A E119* [cytosol] (R-HSA-9648390) p16INK4A A20E [cytosol] (R-HSA-9630855) p16INK4A N39fs14 [cytosol] (R-HSA-9648647) p16INK4A P114R [cytosol] (R-HSA-9631046) p16INK4A P114H [cytosol] (R-HSA-9631043) p16INK4A E27 [cytosol] (R-HSA-9648387) p16INK4A P81S [cytosol] (R-HSA-9632287) p16INK4A G101V [cytosol] (R-HSA-9631263) p16INK4A Y44fs1 [cytosol] (R-HSA-9648664) p16INK4A V126I [cytosol] (R-HSA-9631130) p16INK4A L16fs9 [cytosol] (R-HSA-9648663) p16INK4A V126A [cytosol] (R-HSA-9631126) p16INK4A T18fs8 [cytosol] (R-HSA-9648656) p16INK4A V126F [cytosol] (R-HSA-9631120) p16INK4A L37fs16 [cytosol] (R-HSA-9648659) p16INK4A G35V [cytosol] (R-HSA-9631308) p16INK4A G23D [cytosol] (R-HSA-9630892) p16INK4A R24P [cytosol] (R-HSA-9630828) p16INK4A R80P [cytosol] (R-HSA-9632270) p16INK4A G35A [cytosol] (R-HSA-9631306) p16INK4A E88K [cytosol] (R-HSA-9632548) p16INK4A T77P [cytosol] (R-HSA-9632257) p16INK4A L97R [cytosol] (R-HSA-9632512) p16INK4A T18_A19dup [cytosol] (R-HSA-9632192) p16INK4A G67_N71del [cytosol] (R-HSA-9632252) p16INK4A A60R [cytosol] (R-HSA-9632216) p16INK4A D74Y [cytosol] (R-HSA-9632088) p16INK4A A60V [cytosol] (R-HSA-9632212) p16INK4A R112_L113insR [cytosol] (R-HSA-9632566) p16INK4A R99P [cytosol] (R-HSA-9632531) p16INK4A A60S [cytosol] (R-HSA-9632206) p16INK4A L97P [cytosol] (R-HSA-9632523) p16INK4A G23S [cytosol] (R-HSA-9631163) p16INK4A A60E [cytosol] (R-HSA-9632202) p16INK4A G23V [cytosol] (R-HSA-9631157) p16INK4A G35R [cytosol] (R-HSA-9631316) p16INK4A T77S [cytosol] (R-HSA-9632256) p16INK4A [cytosol] (R-HSA-182578) p16INK4A G35E [cytosol] (R-HSA-9631314) p16INK4A G35W [cytosol] (R-HSA-9631328)	0.952	16
UniProt:P30279 CCND2	2	CCND2 [nucleoplasm] (R-HSA-113827) CCND2 [cytosol] (R-HSA-68340)	0.928	15
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.928	14
UniProt:P46527 CDKN1B	8	CDKN1B [nucleoplasm] (R-HSA-182563) CDKN1B [cytosol] (R-HSA-198622) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.904	7
UniProt:P38936 CDKN1A	5	p-Y77-CDKN1A [cytosol] (R-HSA-8942601) p-T145-CDKN1A [cytosol] (R-HSA-198614) CDKN1A [cytosol] (R-HSA-182512) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857) CDKN1A [nucleoplasm] (R-HSA-182585)	0.883	7
UniProt:Q9UJC3 HOOK1			0.857	14
UniProt:P08238 HSP90AB1	6	HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.723	4
UniProt:Q8N720 ZNF655	1	ZNF655 [nucleoplasm] (R-HSA-2127575)	0.709	6
UniProt:Q9UH17 APOBEC3B	1	APOBEC3B [nucleoplasm] (R-HSA-8875003)	0.65	9
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.592	2
UniProt:P46379 BAG6	1	BAG6 [cytosol] (R-HSA-201567)	0.573	2
UniProt:Q8IZT6 ASPM			0.564	2
UniProt:Q9ULD0 OGDHL			0.556	3
UniProt:Q9UKT9 IKZF3			0.556	6
UniProt:Q0VD86 INCA1			0.556	3
UniProt:Q15047 SETDB1	1	SETDB1 [nucleoplasm] (R-HSA-417136)	0.553	2
UniProt:Q16254 E2F4	1	E2F4 [nucleoplasm] (R-HSA-68664)	0.534	2
UniProt:Q13451 FKBP5	2	FKBP5 [nucleoplasm] (R-HSA-8939165) FKBP5 [cytosol] (R-HSA-5618096)	0.527	2
UniProt:Q14004 CDK13	3	CDK13 [ficolin-1-rich granule lumen] (R-HSA-6801374) CDK13 [extracellular region] (R-HSA-6806442) CDK13 [nucleoplasm] (R-HSA-6797014)	0.527	2
UniProt:Q8N448 LNX2			0.488	2

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