Reactome | BCL2L1 [mitochondrial outer membrane]

BCL2L1 [mitochondrial outer membrane]

Stable Identifier

R-HSA-114236

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

Synonyms

Apoptosis regulator Bcl-X, Bcl-2-like 1 protein

Locations in the PathwayBrowser for interactor UniProt:Q96LC9 BMF

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External Reference Information

External Reference

UniProt:Q07817 BCL2L1

Gene Names

BCL2L1, BCL2L, BCLX

Chain

chain:1-233

Reference Genes

BioGPS Gene:598 BCL2L1

COSMIC (genes):BCL2L1 BCL2L1

CTD Gene:598 BCL2L1

dbSNP Gene:598 BCL2L1

ENSEMBL:ENSG00000171552 BCL2L1

HGNC:992 BCL2L1

KEGG:hsa:598 BCL2L1

Monarch:598 BCL2L1

NCBI Gene:598 BCL2L1

OMIM:600039 BCL2L1

UCSC:Q07817 BCL2L1

Reference Transcript

Participates

as a component of

as an input of

as a member of

Bcl-2/Bcl-X(L) [mitochondrial outer membrane] (Homo sapiens)

Other forms of this molecule

BCL2L1 [cytosol]

Inferred To

BCL2L1 [mitochondrial outer membrane] (Bos taurus)

BCL2L1 [mitochondrial outer membrane] (Gallus gallus)

BCL2L1 [mitochondrial outer membrane] (Sus scrofa)

bcl2l1 [mitochondrial outer membrane] (Danio rerio)

bcl2l1 [mitochondrial outer membrane] (Xenopus tropicalis)

bcl-xL [mitochondrial outer membrane] (Canis familiaris)

Bcl2l1 [mitochondrial outer membrane] (Mus musculus)

Bcl2l1 [mitochondrial outer membrane] (Rattus norvegicus)

ced-9 [mitochondrial outer membrane] (Caenorhabditis elegans)

Cross References

Guide to Pharmacology - Targets

2845

OpenTargets

ENSG00000171552

ENSEMBL

ENSP00000395545, ENSP00000365230, ENSP00000504237, ENST00000676582, ENSP00000389688, ENST00000376062, ENST00000677194, ENSP00000401173, ENSP00000504536, ENST00000678563, ENST00000439267, ENSG00000171552, ENSP00000302564, ENST00000422920, ENST00000420488, ENST00000676942, ENSP00000390760, ENSP00000365223, ENST00000456404, ENST00000307677, ENSP00000503725, ENST00000376055, ENSP00000411252, ENST00000434194, ENSP00000504387

ZINC - Substances

B2CL1_HUMAN

ZINC - Biogenic

B2CL1_HUMAN

ZINC target

Q07817

PRO

Q07817

PDB

6ZHC, 6O0M, 3INQ, 3QKD, 6O0L, 4AQ3, 7JGV, 1R2G, 6F46, 7XGG, 7YAA, 3CVA, 6UVF, 2O2N, 3SP7, 6ST2, 1YSG, 2O1Y, 2YXJ, 7Y8D, 1BXL, 8VWZ, 2YQ6, 8IQL, 8U27, 6O0O, 3WIZ, 5VAY, 7LH7, 3PL7, 9AQZ, 4QVX, 3ZLN, 6YLI, 1R2E, 6UVE, 2B48, 6UVD, 5FMK, 6BF2, 7CA4, 4QVE, 4C52, 2M04, 4QVF, 1YSI, 4PPI, 4A1W, 3FDM, 5AGW, 5C3G, 6LHD, 8WLS, 6DCO, 6O0K, 2MEJ, 6DCN, 6X7I, 4EHR, 6IJQ, 6RNU, 1YSN, 3ZLO, 2LPC, 8VWX, 4BPK, 2O2M, 6UVH, 8FY0, 3SPF, 1MAZ, 1LXL, 2LP8, 4CIN, 2M03, 4Z9V, 6HJL, 5AGX, 3R85, 2ME8, 4TUH, 2PON, 2ME9, 5B1Z, 8IQK, 1R2I, 7JGW, 6O0P, 2YQ7, 6VWC, 3FDL, 1R2D, 1R2H, 3ZLR, 7XGF, 4C5D, 2P1L, 2YJ1, 6UVG, 5FMJ, 4HNJ, 6UVC, 3ZK6, 1G5J, 4IEH, 3IO8, 4A1U, 8XP5, 8VXN, 5VX3, 8VXM

ZINC - Investigational

B2CL1_HUMAN

ZINC - Metabolites

B2CL1_HUMAN

GeneCards

BCL2L1

HPA

ENSG00000171552-BCL2L1

Pharos - Targets

Q07817

ZINC - Predictions - Purchasable

B2CL1_HUMAN

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92934 BAD	4	p-S99-BAD [cytosol] (R-HSA-198335) BAD [cytosol] (R-HSA-50662) BAD [mitochondrial outer membrane] (R-HSA-114242) p-S91-BAD [cytosol] (R-HSA-217297)	0.977	50
UniProt:Q16611 BAK1	2	BAK1 activated [mitochondrial outer membrane] (R-HSA-50690) BAK1 [mitochondrial outer membrane] (R-HSA-139896)	0.958	38
UniProt:Q13323 BIK			0.914	12
UniProt:O43521 BCL2L11	7	BCL2L11 [cytosol] (R-HSA-2976673) p-BCL2L11 [cytosol] (R-HSA-140525) p-BCL2L11 [mitochondrial outer membrane] (R-HSA-3145027) p-S69-BCL2L11 [cytosol] (R-HSA-2976671) BCL2L11(1-131)-p-BRAF(397-766) fusion [cytosol] (R-HSA-6802519) BCL2L11(1-131)-BRAF(397-766) fusion [cytosol] (R-HSA-6802276) BCL2L11 [mitochondrial outer membrane] (R-HSA-2976674)	0.826	11
UniProt:Q96LC9 BMF	3	BMF [plasma membrane] (R-HSA-140209) p-BMF(1-89) [cytosol] (R-HSA-140529) p-BMF [mitochondrial outer membrane] (R-HSA-3145026)	0.805	12
UniProt:P55957 BID	4	BID(62-195) [cytosol] (R-HSA-139953) BID(1-195) [cytosol] (R-HSA-50825) MYS-BID(62-195) [cytosol] (R-HSA-141373) MYS-BID(62-195) [mitochondrial outer membrane] (R-HSA-114266)	0.675	3
UniProt:Q9C000 NLRP1	1	NLRP1 [cytosol] (R-HSA-561196)	0.646	9
UniProt:Q07812 BAX	3	BAX [mitochondrial outer membrane] (R-HSA-139949) BAX activated [cytosol] (R-HSA-139907) BAX [cytosol] (R-HSA-139916)	0.615	5
UniProt:Q14457 BECN1	4	BECN1 [cytosol] (R-HSA-1632841) p-S15-BECN1 [cytosol] (R-HSA-5682391) ISG15-K-BECN1 [cytosol] (R-HSA-9853030) K63polyUb-BECN1 [cytosol] (R-HSA-6782989)	0.564	2
UniProt:Q7Z5B4-5 RIC3			0.556	3
UniProt:P78317 RNF4	2	RNF4 [nucleoplasm] (R-HSA-5684076) RNF4 [cytosol] (R-HSA-975974)	0.556	3
UniProt:Q9GZR5 ELOVL4	1	ELOVL4 [endoplasmic reticulum membrane] (R-HSA-548705)	0.556	3
UniProt:Q6NTF9-3 Q6NTF93			0.556	3
UniProt:Q9H6H4 REEP4			0.556	3
UniProt:P27469 G0S2	1	G0S2 [lipid droplet] (R-HSA-1989741)	0.556	3
UniProt:Q5T7V8 GORAB			0.556	3
UniProt:Q9H2K0 MTIF3	1	MTIF3 [mitochondrial matrix] (R-HSA-5368284)	0.556	3
UniProt:Q8IYJ2-2 C10ORF67			0.556	3
UniProt:Q9Y282 ERGI3			0.556	3
UniProt:Q8NBJ4 GOLM1	2	p-GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956938) GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956710)	0.556	3
UniProt:P22749 GNLY	2	GNLY [phagocytic vesicle lumen] (R-HSA-6807564) GNLY [extracellular region] (R-HSA-6806691)	0.556	3
UniProt:P56557 TM50B			0.556	3
UniProt:P0C671 BNIP5			0.556	3
UniProt:Q7KZS0 Q7KZS0			0.556	3
UniProt:P37840 SNCA	5	SNCA [cytosol] (R-HSA-5658500) p-S129-SNCA [cytosol] (R-HSA-9836432) Ub-SNCA [cytosol] (R-HSA-5660754) SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569)	0.556	3
UniProt:P49810 PSEN2	2	PSEN2(298-448) [plasma membrane] (R-HSA-9013329) PSEN2(1-297) [plasma membrane] (R-HSA-201599)	0.543	3
UniProt:Q07817 BCL2L1	2	BCL2L1 [mitochondrial outer membrane] (R-HSA-114236) BCL2L1 [cytosol] (R-HSA-50771)	0.524	2
UniProt:P45983 MAPK8	3	p-T,Y-MAPK8 [nucleoplasm] (R-HSA-216349) p-T,Y-MAPK8 [cytosol] (R-HSA-194371) MAPK8 [cytosol] (R-HSA-168141)	0.516	2
UniProt:Q9H2V7 SPNS1			0.463	3

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