Reactome | BAD [mitochondrial outer membrane]

BAD [mitochondrial outer membrane]

Stable Identifier

R-HSA-114242

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

Synonyms

BAD protein, Bcl2-antagonist of cell death, Bcl-2 binding component 6, Bcl- XL/Bcl-2 associated death promoter, Bcl-2-like 8 protein

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Locations in the PathwayBrowser for interactor UniProt:Q15323 KRT31

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External Reference Information

External Reference

UniProt:Q92934 BAD

Gene Names

BAD, BBC6, BCL2L8

Chain

chain:1-168

Reference Genes

BioGPS Gene:572 BAD

COSMIC (genes):BAD BAD

CTD Gene:572 BAD

dbSNP Gene:572 BAD

ENSEMBL:ENSG00000002330 BAD

HGNC:936 BAD

KEGG Gene (Homo sapiens):572 BAD

Monarch:572 BAD

NCBI Gene:572 BAD

OMIM:603167 BAD

UCSC:Q92934 BAD

Reference Transcript

Other Identifiers

0002350358

0004050010

11727106_a_at

11750088_x_at

16739872

1861_at

209364_at

3376833

3376834

3376835

3376836

3376839

3376843

3376844

3376845

572

7949067

A_23_P150207

A_33_P3262043

GE61740

GO:0000003

GO:0001666

GO:0001836

GO:0001844

GO:0002376

GO:0003674

GO:0005515

GO:0005543

GO:0005575

GO:0005622

GO:0005737

GO:0005739

GO:0005741

GO:0005829

GO:0005975

GO:0006007

GO:0006810

GO:0006914

GO:0006915

GO:0006919

GO:0006950

GO:0007005

GO:0007155

GO:0007165

GO:0007267

GO:0007283

GO:0008150

GO:0008219

GO:0008283

GO:0008289

GO:0008625

GO:0008630

GO:0008656

GO:0009056

GO:0009725

GO:0009749

GO:0010033

GO:0010508

GO:0010918

GO:0014070

GO:0015031

GO:0016020

GO:0019050

GO:0019221

GO:0019899

GO:0019901

GO:0019903

GO:0021987

GO:0022607

GO:0030154

GO:0030234

GO:0030346

GO:0032024

GO:0032355

GO:0032570

GO:0033133

GO:0033574

GO:0034201

GO:0034641

GO:0035774

GO:0042493

GO:0042542

GO:0042592

GO:0042593

GO:0042981

GO:0043065

GO:0043167

GO:0043200

GO:0043226

GO:0043280

GO:0043281

GO:0043422

GO:0044281

GO:0044342

GO:0044403

GO:0045471

GO:0045579

GO:0045582

GO:0045862

GO:0046031

GO:0046034

GO:0046902

GO:0046931

GO:0048856

GO:0050679

GO:0051384

GO:0051592

GO:0051604

GO:0060139

GO:0061024

GO:0065003

GO:0071247

GO:0071260

GO:0071316

GO:0071396

GO:0071456

GO:0071889

GO:0090200

GO:0097190

GO:0097191

GO:0097192

GO:0097193

GO:0097202

GO:1900740

GO:1901216

GO:1901423

GO:1902220

GO:1904710

GO:2000078

GO:2001244

ILMN_1720360

ILMN_1738652

PH_hs_0004408

TC11001903.hg

U66879_at

g1683636_3p_s_at

Participant Of

hasMember

Bcl-XL interacting BH3-only proteins [mitochondrial outer membrane]

hasCandidate

Bcl-2 interacting BH-3 only proteins [mitochondrial outer membrane]

hasComponent

BAD:BCL-2 [mitochondrial outer membrane]

input

BAD displaces tBID from BCL-2 sequestration

output

Translocation of activated BAD protein to mitochondria

Other forms of this molecule

BAD [cytosol]

p-S99-BAD [cytosol]

p-S128-BAD [cytosol]

Inferred To

BAD [mitochondrial outer membrane] (Bos taurus)

BAD [mitochondrial outer membrane] (Canis familiaris)

BAD [mitochondrial outer membrane] (Sus scrofa)

BAD [mitochondrial outer membrane] (Xenopus tropicalis)

Bad [mitochondrial outer membrane] (Mus musculus)

Bad [mitochondrial outer membrane] (Rattus norvegicus)

badb [mitochondrial outer membrane] (Danio rerio)

Cross References

ZINC - Investigational

BAD_HUMAN

RefSeq

NP_004313.1, NP_116784.1

Target Pathogen

5b354852be737e166372ecfe

OpenTargets

ENSG00000002330

ZINC - Substances

BAD_HUMAN

GeneCards

Q92934

HPA

ENSG00000002330-BAD

ZINC target

Q92934

Ensembl

ENSP00000378040, ENST00000309032, ENST00000394532, ENSP00000309103, ENSG00000002330

PRO

Q92934

ZINC - Predictions - Purchasable

BAD_HUMAN

PDB

1G5J

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q07817 BCL2L1	2	BCL2L1 [mitochondrial outer membrane] (R-HSA-114236) BCL2L1 [cytosol] (R-HSA-50771)	0.974	34
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.864	8
UniProt:P10415 BCL2	1	BCL2 [mitochondrial outer membrane] (R-HSA-50757)	0.807	5
UniProt:Q07817-1 BCL2L1			0.807	6
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.804	6
UniProt:Q92843 B2CL2			0.765	7
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.738	5
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.687	5
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.667	4
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.659	4
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.659	4
UniProt:P04049 RAF1	54	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) RAF1 [cytosol] (R-HSA-167205) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098) p-S621-RAF1 G361A [cytosol] (R-HSA-9656092) p-S621-RAF1 G370R [cytosol] (R-HSA-9656094) p-S621-RAF1 D486G [cytosol] (R-HSA-9656085) p-S621-RAF1 T491R [cytosol] (R-HSA-9656145) p-S338,Y341,T492,S494,S621 RAF1 D486N [cytosol] (R-HSA-9656026) p-S338,Y341,T492,S494,S621 RAF1 S427G [cytosol] (R-HSA-9656070) p-S338,Y341,T492,S494,S621 RAF1 L613V [cytosol] (R-HSA-9656035) p-S338,Y341,S494,S621-RAF1 T491I [cytosol] (R-HSA-9656019) p-S338,Y341,T492,S494,S621 RAF1 G361A [cytosol] (R-HSA-9656029) p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol] (R-HSA-9656031) p-S338,Y341,T492,S494,S621 RAF1 D486G [cytosol] (R-HSA-9656023) p-S338,Y341,S494,S621 RAF1 T491R [cytosol] (R-HSA-9656017) p-S338,Y341,T492,S494,S621 RAF1 S259F [cytosol] (R-HSA-9656062) p-S338,Y341,T492,S494,S621 RAF1 P261A [cytosol] (R-HSA-9656041) p-S338,Y341,T492,S494,S621 RAF1 S257L [cytosol] (R-HSA-9656058) p-S338,Y341,T492,S494,S621 RAF1 P261L [cytosol] (R-HSA-9656043) p-S338,Y341,T492,S494,S621 RAF1 P261T [cytosol] (R-HSA-9656053) p-S338,Y341,T492,S494,S621 RAF1 N262K [cytosol] (R-HSA-9656037) p-S338,Y341,T492,S494,S621 RAF1 P261S [cytosol] (R-HSA-9656050) p-S338,Y341,T492,S494,S621 RAF1 S259T [cytosol] (R-HSA-9656067) p-S338,Y341,T492,S494,S621 RAF1 T260R [cytosol] (R-HSA-9656077) p-S338,Y341,T492,S494,S621 RAF1 P261R [cytosol] (R-HSA-9656047) p-S338,Y341,T492,S494,S621 RAF1 R256S [cytosol] (R-HSA-9656056) p-S338,Y341,T492,S494,S621 RAF1 T260I [cytosol] (R-HSA-9656074) p-S338,Y341,T492,S494,S621 RAF1 V263A [cytosol] (R-HSA-9656080) p-S338,Y341,T492,S494,S621 RAF1 S259P [cytosol] (R-HSA-9656065) hyperphosphorylated RAF1 [plasma membrane] (R-HSA-5675193) p-S621-RAF1 [plasma membrane] (R-HSA-206222) p-Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5675420) p-S259,S621-RAF1 [cytosol] (R-HSA-109786) p-S621-RAF1 [cytosol] (R-HSA-206028) p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5672665) p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (R-HSA-5672664)	0.589	2
UniProt:P07384 CAPN1	4	CAPN1 [ficolin-1-rich granule lumen] (R-HSA-6801284) CAPN1 [plasma membrane] (R-HSA-3828038) CAPN1 [extracellular region] (R-HSA-6806485) CAPN1 [cytosol] (R-HSA-3288367)	0.556	3
UniProt:P35609 ACTN2	3	ACTN2 [platelet alpha granule lumen] (R-HSA-349727) ACTN2 [cytosol] (R-HSA-390562) ACTN2 [extracellular region] (R-HSA-349725)	0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P17361 N1			0.524	2
UniProt:P03495 NS1			0.508	2
UniProt:O43521 BCL2L11	7	p-S65-BCL2L11 [cytosol] (R-HSA-2976671) BCL2L11 [mitochondrial outer membrane] (R-HSA-2976674) BCL2L11-BRAF fusion [cytosol] (R-HSA-6802276) p-BCL2L11-BRAF fusion [cytosol] (R-HSA-6802519) BCL2L11 [cytosol] (R-HSA-2976673) p-BCL2L11 [mitochondrial outer membrane] (R-HSA-3145027) p-BCL2L11 [cytosol] (R-HSA-140525)	0.499	2

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