Cleavage of Procaspase-7 by the apoptosome

Stable Identifier
R-HSA-114261
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Cleavage of Procaspase-7 by the apoptosome
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Caspases-3 and -7 are directly cleaved downstream of caspase-9 in the cytochrome c/Apaf-1-inducible caspase cascade (Slee et al., 1999).
Literature References
PubMed ID Title Journal Year
11701129 Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding

Alnemri, ES, Chai, J, Shi, Y, Srinivasula, SM, Shiozaki, E, Wu, Q

Cell 2001
12824163 Human caspase-7 activity and regulation by its N-terminal peptide

Denault, JB, Salvesen, GS

J. Biol. Chem. 2003
11752425 Structural basis for the activation of human procaspase-7

Kairies, N, Fuentes-Prior, P, Riedl, SJ, Bode, W, Huber, R, Salvesen, GS, Renatus, M, Krapp, S

Proc. Natl. Acad. Sci. U.S.A. 2001
16916640 Engineered hybrid dimers: tracking the activation pathway of caspase-7

Békés, M, Sexton, KM, Denault, JB, Bogyo, M, Scott, FL, Salvesen, GS

Mol. Cell 2006
9922454 Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

Wolf, BB, Reed, JC, Kluck, RM, Newmeyer, DD, Wang, HG, Casiano, CA, Harte, MT, Slee, EA, Martin, SJ, Green, DR, Nicholson, DW, Alnemri, ES

J Cell Biol 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cysteine-type endopeptidase activity of Apoptosome [cytosol]

Physical Entity
Apoptosome [cytosol] (Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
This event is regulated
Negatively by
Regulator
XIAP [cytosol] (Homo sapiens)
Orthologous Events
Cleavage of Procaspase-7 by the apoptosome (Bos taurus)
Cleavage of Procaspase-7 by the apoptosome (Canis familiaris)
Cleavage of Procaspase-7 by the apoptosome (Danio rerio)
Cleavage of Procaspase-7 by the apoptosome (Gallus gallus)
Cleavage of Procaspase-7 by the apoptosome (Mus musculus)
Cleavage of Procaspase-7 by the apoptosome (Rattus norvegicus)
Cleavage of Procaspase-7 by the apoptosome (Sus scrofa)
Cleavage of Procaspase-7 by the apoptosome (Xenopus tropicalis)
Authored
Alnemri, E  (2004-02-17)
Reviewed
Matthews, L  (2018-09-25)
Created
Alnemri, E  (2004-02-17)
Cite Us!