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Oligomerization of BAK at the mitochondrial membrane
Stable Identifier
R-HSA-114263
Type
Reaction [binding]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Activation and oligomerization of BAK protein (Homo sapiens)
Oligomerization of BAK at the mitochondrial membrane (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Once activated BAK insterts in the outer mitochondrial membrane, it oligomerizes and these oligomeric BAK complexes are important for the cytochrome C efflux (Ruffolo and Shore 2003).
Literature References
PubMed ID
Title
Journal
Year
12721291
BCL-2 selectively interacts with the BID-induced open conformer of BAK, inhibiting BAK auto-oligomerization
Shore, GC
,
Ruffolo, SC
J Biol Chem
2003
Participants
Input
x 2
BAK1 activated [mitochondrial outer membrane]
(Homo sapiens)
Output
Active oligomeric BAK [mitochondrial outer membrane]
(Homo sapiens)
Participates
as an event of
Activation and oligomerization of BAK protein (Homo sapiens)
Orthologous Events
Oligomerization of BAK at the mitochondrial membrane (Bos taurus)
Oligomerization of BAK at the mitochondrial membrane (Canis familiaris)
Oligomerization of BAK at the mitochondrial membrane (Gallus gallus)
Oligomerization of BAK at the mitochondrial membrane (Mus musculus)
Oligomerization of BAK at the mitochondrial membrane (Rattus norvegicus)
Oligomerization of BAK at the mitochondrial membrane (Sus scrofa)
Created
Hardwick, JM (2004-08-09)
Tsujimoto, Y (2004-08-09)
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