Reactome | Translocation of activated BAX to the mitochondria

Translocation of activated BAX to the mitochondria

Stable Identifier

R-HSA-114264

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, mitochondrial outer membrane

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Translocation of activated BAX to the mitochondria

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Activated BAX integrates in the outer mitochondrial membrane (Eskes et al. 2000, Antonsson et al. 2001, Bellosillo et al. 2002, Yi et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12624108	Inhibition of Bid-induced apoptosis by Bcl-2. tBid insertion, Bax translocation, and Bax/Bak oligomerization suppressed Yi, X, Yin, XM, Dong, Z	J Biol Chem	2003
11136736	Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells. Antonsson, B, Montessuit, S, Sanchez, B, Martinou, JC	J Biol Chem	2001
10629050	Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane Eskes, R, Desagher, S, Antonsson, B, Martinou, JC	Mol Cell Biol	2000
12176904	Spontaneous and drug-induced apoptosis is mediated by conformational changes of Bax and Bak in B-cell chronic lymphocytic leukemia. Bellosillo, B, Villamor, N, López-Guillermo, A, Marcé, S, Bosch, F, Campo, E, Montserrat, E, Colomer, D	Blood	2002