Translocation of activated BAX to the mitochondria

Stable Identifier
R-HSA-114264
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Activated BAX integrates in the outer mitochondrial membrane (Eskes et al. 2000, Antonsson et al. 2001, Bellosillo et al. 2002, Yi et al. 2003).

Literature References
PubMed ID Title Journal Year
12624108 Inhibition of Bid-induced apoptosis by Bcl-2. tBid insertion, Bax translocation, and Bax/Bak oligomerization suppressed

Yi, X, Yin, XM, Dong, Z

J Biol Chem 2003
11136736 Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells.

Antonsson, B, Montessuit, S, Sanchez, B, Martinou, JC

J Biol Chem 2001
10629050 Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

Eskes, R, Desagher, S, Antonsson, B, Martinou, JC

Mol Cell Biol 2000
12176904 Spontaneous and drug-induced apoptosis is mediated by conformational changes of Bax and Bak in B-cell chronic lymphocytic leukemia.

Bellosillo, B, Villamor, N, López-Guillermo, A, Marcé, S, Bosch, F, Campo, E, Montserrat, E, Colomer, D

Blood 2002
Participants
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Event Information
Orthologous Events
Created