Reactome | DIABLO [cytosol]

DIABLO [cytosol]

Stable Identifier

R-HSA-114298

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SMAC, Smac protein, mitochondrial precursor, Second mitochondria-derived activator of caspase, Direct IAP binding protein with low pI

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9NR28 DIABLO

Gene Names

DIABLO, SMAC

Chain

transit peptide:1-21, chain:22-239, chain:56-239

Reference Genes

BioGPS Gene:56616 DIABLO

COSMIC (genes):DIABLO DIABLO

CTD Gene:56616 DIABLO

dbSNP Gene:56616 DIABLO

ENSEMBL:ENSG00000184047 DIABLO

HGNC:21528 DIABLO

KEGG:hsa:56616 DIABLO

Monarch:56616 DIABLO

NCBI Gene:56616 DIABLO

OMIM:605219 DIABLO

UCSC:Q9NR28 DIABLO

Reference Transcript

Participates

as an input of

SMAC (DIABLO) forms dimer (Homo sapiens)

as an output of

Release of SMAC (DIABLO) from mitochondria (Homo sapiens)

as a component of

DIABLO dimer [cytosol] (Homo sapiens)

Other forms of this molecule

DIABLO [mitochondrial intermembrane space]

Inferred To

diablo [cytosol] (Xenopus tropicalis)

Diablol1 [cytosol] (Rattus norvegicus)

Diablo [cytosol] (Mus musculus)

DIABLO [cytosol] (Bos taurus)

DIABLO [cytosol] (Canis familiaris)

DIABLO [cytosol] (Gallus gallus)

DIABLO [cytosol] (Sus scrofa)

diabloa [cytosol] (Danio rerio)

Cross References

ENSEMBL

ENSG00000184047, ENSP00000442360, ENST00000464942, ENSP00000320343, ENST00000353548

OpenTargets

ENSG00000184047

GeneCards

DIABLO

HPA

ENSG00000184047-DIABLO

PRO

Q9NR28

Pharos - Targets

Q9NR28

GlyGen

Q9NR28

Orphanet

DIABLO

PDB

8E2I, 8ATO, 8AUW, 8E2J, 1TW6, 6JX6, 1G3F, 3UIJ, 1OXQ, 1G73, 3D9U, 1XB1, 4TX5, 1XB0, 1FEW, 3UIH

Interactors (33)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P98170 XIAP	3	XIAP [cytosol] (R-HSA-50849) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [nucleoplasm] (R-HSA-3322366)	0.933	11
UniProt:Q13490 BIRC2	5	BIRC2 [cytosol] (R-HSA-50847) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512)	0.825	8
UniProt:Q15041 AR6P1			0.805	9
UniProt:Q96FJ2 DYNLL2	4	DYNLL2 [cytosol] (R-HSA-2029024) DYNLL2 [plasma membrane] (R-HSA-140527) DYNLL2 [cilium] (R-HSA-5624865) DYNLL2 [ciliary tip] (R-HSA-5625337)	0.725	4
UniProt:Q6RW13-2 AGTRAP			0.718	6
UniProt:Q96CA5 BIRC7	1	BIRC7 [cytosol] (R-HSA-50855)	0.688	9
UniProt:Q13489 BIRC3	3	BIRC3 [cytosol] (R-HSA-50845) K48pUb-BIRC3 [cytosol] (R-HSA-5675478) K63polyUb-BIRC3 [cytosol] (R-HSA-5668478)	0.669	3
UniProt:Q15390 MTFR1			0.666	5
UniProt:P63167 DYNLL1	6	DYNLL1 [cytosol] (R-HSA-387105) DYNLL1 [plasma membrane] (R-HSA-54017) DYNLL1 [tertiary granule membrane] (R-HSA-6801482) DYNLL1 [ficolin-1-rich granule membrane] (R-HSA-6801518) DYNLL1 [cilium] (R-HSA-5624863) DYNLL1 [ciliary tip] (R-HSA-5625335)	0.638	3
UniProt:Q60989	3	XIAP [nucleoplasm] (R-MMU-3322366) K48pUb-XIAP [cytosol] (R-MMU-5675477) XIAP [cytosol] (R-MMU-50849)	0.564	3
UniProt:Q7Z5P4 HSD17B13	1	HSD17B13 [cytosol] (R-HSA-8862029)	0.556	3
UniProt:Q9NPL8 TIMMDC1	1	TIMMDC1 [mitochondrial inner membrane] (R-HSA-5689720)	0.556	3
UniProt:Q6ZPD8 DGAT2L6	1	DGAT2L6 [endoplasmic reticulum membrane] (R-HSA-8848588)	0.556	3
UniProt:P55056 APOC4	1	APOC4 [extracellular region] (R-HSA-5215930)	0.556	3
UniProt:P27449 ATP6V0C	7	ATP6V0C [endosome membrane] (R-HSA-912591) ATP6V0C [phagocytic vesicle membrane] (R-HSA-1222603) ATP6V0C [tertiary granule membrane] (R-HSA-6800991) ATP6V0C [plasma membrane] (R-HSA-6806254) ATP6V0C [azurophil granule membrane] (R-HSA-6799363) ATP6V0C [ficolin-1-rich granule membrane] (R-HSA-6800908) ATP6V0C [lysosomal membrane] (R-HSA-9640194)	0.556	3
UniProt:Q08426 EHHADH	2	EHHADH [peroxisomal matrix] (R-HSA-400155) EHHADH [cytosol] (R-HSA-9033147)	0.556	3
UniProt:Q5XKP0 MICOS13	1	MIC13 (QIL1) [mitochondrial inner membrane] (R-HSA-8949561)	0.556	3
UniProt:Q8N2U9 S66A2			0.556	3
UniProt:P08247 SYP	1	SYP [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-5215991)	0.556	3
UniProt:Q8IZR5-2 Q8IZR52			0.556	3
UniProt:Q96LZ7 RMD2			0.556	3
UniProt:Q9GZP9 DERL2	1	DERL2 [endoplasmic reticulum membrane] (R-HSA-5362350)	0.556	3
UniProt:Q6NTF9-3 Q6NTF93			0.556	3
UniProt:Q9BYT1 S17A9			0.556	3
UniProt:Q8WV19 SFT2A			0.556	3
UniProt:Q9Y680 FKBP7			0.556	3
UniProt:Q96IW7 SEC22A	3	SEC22A [endoplasmic reticulum membrane] (R-HSA-5216111) SEC22A [ER to Golgi transport vesicle membrane] (R-HSA-5688560) SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688562)	0.556	3
UniProt:Q8N9I5 FADS6			0.556	3
UniProt:O95563 MPC2	1	MPC2 [mitochondrial inner membrane] (R-HSA-2512891)	0.556	3
UniProt:Q9H169-2 Q9H1692			0.556	3
UniProt:Q96LJ7 DHRS1			0.556	3
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.527	3
UniProt:P10809 HSPD1	6	HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1 [mitochondrial matrix] (R-HSA-1299448)	0.527	5

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