SMAC binds XIAP:Caspase-7

Stable Identifier
R-HSA-114354
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The linker region preceding BIR2 of XIAP is responsible for the inhibition of caspase‑3 and ‑7, which is further stabilized by interaction with the BIR2 domain itself (Scott et al. 2005). Binding of a dimeric SMAC (DIABLO) N‑terminal peptide with the BIR2 domain of XIAP effectively antagonized inhibition of caspase‑7 by XIAP (Wu G et al. 2000; Chai J et al. 2000).

Literature References
PubMed ID Title Journal Year
9230442 X-linked IAP is a direct inhibitor of cell-death proteases.

Deveraux, QL, Takahashi, R, Salvesen, GS, Reed, JC

Nature 1997
11257231 Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain

Huang, Y, Park, YC, Rich, RL, Segal, D, Myszka, DG, Wu, H

Cell 2001
14960576 Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells.

Yang, QH, Du, C

J Biol Chem 2004
18619610 A mechanistic insight into SMAC peptide interference with XIAP-Bir2 inhibition of executioner caspases

Abhari, BA, Davoodi, J

J. Mol. Biol. 2008
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