Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7

Stable Identifier
R-HSA-114392
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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The linker region preceding BIR2 of XIAP is responsible for the inhibition of caspase-3 and -7, which is further stabilized by interaction with the BIR2 domain itself (Scott et al. 2005). Binding of a dimeric SMAC (DIABLO) N-terminal peptide with the BIR2 domain of XIAP effectively antagonized inhibition of caspase-7 by XIAP (Wu G et al. 2000; Chai J et al. 2000). As DIABLO has a higher affinity for the BIR2 domain than caspase-7, DIABLO (SMAC) binding to XIAP results in the liberation of caspase-7 (Huang et al. 2001).

Literature References
PubMed ID Title Journal Year
11257231 Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain

Huang, Y, Park, YC, Rich, RL, Segal, D, Myszka, DG, Wu, H

Cell 2001
Participants
Participant Of
Orthologous Events
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