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ITGA2B(32-?) [platelet alpha granule membrane]
Stable Identifier
R-HSA-114511
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
platelet alpha granule membrane
Synonyms
Integrin alpha-IIb, Platelet membrane glycoprotein IIb, GPalpha IIb, GPIIb, CD41 antigen
Icon
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Surface deployment of platelet alpha granule membrane components (Homo sapiens)
Platelet alpha granule membrane components that are released on degranulation [platelet alpha granule membrane] (Homo sapiens)
Alpha IIb Beta 3 Integrin [platelet alpha granule membrane] (Homo sapiens)
ITGA2B(32-?) [platelet alpha granule membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08514 ITGA2B
Gene Names
ITGA2B, GP2B, ITGAB
Chain
signal peptide:1-31, chain:32-1039, chain:32-887, chain:891-1039, chain:903-1039
Reference Genes
BioGPS Gene:3674 ITGA2B
COSMIC (genes):ITGA2B ITGA2B
CTD Gene:3674 ITGA2B
dbSNP Gene:3674 ITGA2B
ENSEMBL:ENSG00000005961 ITGA2B
ENSEMBL_homo_sapiens_GENE:ENSG00000005961.19 ITGA2B
HGNC:6138 ITGA2B
KEGG Gene (Homo sapiens):3674 ITGA2B
Monarch:3674 ITGA2B
NCBI Gene:3674 ITGA2B
OMIM:607759 ITGA2B
UCSC:P08514 ITGA2B
Reference Transcript
RefSeq:NM_000419.4 ITGA2B
RefSeq:XM_011524749.1 ITGA2B
Other Identifiers
11731160_a_at
11731161_at
11749951_a_at
16845681
206493_PM_at
206493_at
206494_PM_s_at
206494_s_at
216956_PM_s_at
216956_s_at
3674
3759139
3759140
3759141
3759142
3759143
3759145
3759147
3759148
3759149
3759151
3759152
3759153
3759154
3759155
3759156
3759157
3759158
3759159
3759160
3759161
3759163
3759164
3759165
3759166
3759167
3759168
3759170
3759171
3759173
3759174
3759175
3759176
3759178
3759180
3759182
3759183
3759184
40643_at
40644_g_at
8016044
A_23_P77971
A_24_P65373
GO:0001525
GO:0002376
GO:0002687
GO:0005178
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0005925
GO:0007155
GO:0007160
GO:0007229
GO:0008305
GO:0009897
GO:0009986
GO:0016020
GO:0023052
GO:0031092
GO:0031410
GO:0033627
GO:0042802
GO:0043226
GO:0046872
GO:0048856
GO:0048870
GO:0050840
GO:0060090
GO:0070051
GO:0070062
GO:0072562
GO:0098609
HMNXSV003040038
Hs.785.1.S1_3p_a_at
ILMN_1721888
M34344_at
PH_hs_0024867
TC17001581.hg
g6006009_3p_at
Participates
as a component of
Alpha IIb Beta 3 Integrin [platelet alpha granule membrane] (Homo sapiens)
Other forms of this molecule
ITGA2B(32-1039) [plasma membrane]
Inferred To
itga2b.1 [platelet alpha granule membrane]
(Xenopus tropicalis)
ITGA2B [platelet alpha granule membrane]
(Bos taurus)
ITGA2B [platelet alpha granule membrane]
(Canis familiaris)
ITGA2B [platelet alpha granule membrane]
(Sus scrofa)
si:dkey-27b3.6 [platelet alpha granule membrane]
(Danio rerio)
pat-2 [platelet alpha granule membrane]
(Caenorhabditis elegans)
ITGA2B(32-?) [platelet alpha granule membrane]
(Gallus gallus)
ITGA2B(32-?) [platelet alpha granule membrane]
(Mus musculus)
if [platelet alpha granule membrane]
(Drosophila melanogaster)
Itga2b [platelet alpha granule membrane]
(Rattus norvegicus)
Cross References
RefSeq
XP_011523051.1
,
NP_000410.2
Guide to Pharmacology - Targets
2441
OpenTargets
ENSG00000005961
ZINC - Substances
ITA2B_HUMAN
ZINC target
P08514
PRO
P08514
PDB
3ZDY
,
4CAK
,
2VDM
,
2KNC
,
1DPQ
,
2VC2
,
2VDN
,
3ZDX
,
7L8P
,
4Z7Q
,
7TCT
,
1S4W
,
3ZE2
,
2VDO
,
7TPD
,
5HDB
,
7SFT
,
2VDP
,
7UH8
,
7UBR
,
3ZE1
,
7UJE
,
7U60
,
7UKO
,
2N9Y
,
7UE0
,
7UFH
,
7THO
,
1KUP
,
7U9F
,
3FCS
,
2VDQ
,
4Z7O
,
1TYE
,
7UJK
,
7UKT
,
2VDL
,
2K9J
,
1DPK
,
7UKP
,
7TD8
,
7UK9
,
3ZE0
,
7LA4
,
7KN0
,
7UCY
,
2MTP
,
7UDH
,
3T3P
,
3NID
,
3ZDZ
,
7UDG
,
7TMZ
,
3T3M
,
7SC4
,
3NIF
,
3FCU
,
6V4P
,
2VDR
,
3NIG
,
1M8O
,
1KUZ
,
7U9V
,
2K1A
,
2VDK
,
4Z7N
GeneCards
P08514
HPA
ENSG00000005961-ITGA2B
Ensembl
ENST00000262407
,
ENSG00000005961
,
ENSP00000262407
Pharos - Targets
P08514
ZINC - Predictions - Purchasable
ITA2B_HUMAN
Orphanet
16271
HMDB Protein
HMDBP02103
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05106 ITGB3
3
p-T779-ITGB3 [plasma membrane]
(R-HSA-432107)
ITGB3(27-?) [platelet alpha granule membrane]
(R-HSA-114512)
ITGB3 [plasma membrane]
(R-HSA-57600)
0.815
12
UniProt:P08514 ITGA2B
2
ITGA2B(32-?) [platelet alpha granule membrane]
(R-HSA-114511)
ITGA2B(32-1039) [plasma membrane]
(R-HSA-57578)
0.795
7
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