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ITGB3(27-?) [platelet alpha granule membrane]
Stable Identifier
R-HSA-114512
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
platelet alpha granule membrane
Synonyms
Integrin beta-3, Platelet membrane glycoprotein IIIa, GPIIIa, CD61 antigen
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Surface deployment of platelet alpha granule membrane components (Homo sapiens)
Platelet alpha granule membrane components that are released on degranulation [platelet alpha granule membrane] (Homo sapiens)
Alpha IIb Beta 3 Integrin [platelet alpha granule membrane] (Homo sapiens)
ITGB3(27-?) [platelet alpha granule membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P05106 ITGB3
Gene Names
ITGB3, GP3A
Chain
signal peptide:1-26, chain:27-788
Reference Genes
BioGPS Gene:3690 ITGB3
COSMIC (genes):ITGB3 ITGB3
CTD Gene:3690 ITGB3
dbSNP Gene:3690 ITGB3
ENSEMBL:ENSG00000259207 ITGB3
ENSEMBL_homo_sapiens_GENE:ENSG00000259207.10 ITGB3
HGNC:6156 ITGB3
KEGG Gene (Homo sapiens):3690 ITGB3
Monarch:3690 ITGB3
NCBI Gene:3690 ITGB3
OMIM:173470 ITGB3
UCSC:P05106 ITGB3
Reference Transcript
RefSeq:NM_000212.2 ITGB3
Other Identifiers
11735062_at
11735063_a_at
11735064_at
11735065_a_at
11735066_at
11755065_a_at
1176_at
16835158
204625_PM_s_at
204625_s_at
204626_PM_s_at
204626_s_at
204627_PM_s_at
204627_s_at
204628_PM_s_at
204628_s_at
216261_PM_at
216261_at
242094_PM_at
242094_at
3690
3724547
3724552
3724554
3724555
3724556
3724557
3724558
3724559
3724560
3724562
3724563
3724564
3724566
3724569
3724570
3724571
3724572
3724573
3724574
3724575
3724576
3724577
3724582
3724583
3724584
3724585
37952_at
73263_at
8007931
A_14_P115980
A_14_P131651
A_23_P38519
A_24_P318656
A_24_P889473
GE57949
GO:0001618
GO:0001934
GO:0001938
GO:0001954
GO:0001968
GO:0002020
GO:0002376
GO:0002687
GO:0003756
GO:0003824
GO:0005080
GO:0005161
GO:0005178
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005886
GO:0005911
GO:0005925
GO:0007010
GO:0007044
GO:0007155
GO:0007160
GO:0007229
GO:0007566
GO:0007596
GO:0008277
GO:0008305
GO:0009897
GO:0009986
GO:0010595
GO:0010628
GO:0010745
GO:0010763
GO:0010888
GO:0012501
GO:0014823
GO:0014909
GO:0014911
GO:0015026
GO:0016020
GO:0016192
GO:0016324
GO:0016853
GO:0017134
GO:0019899
GO:0019960
GO:0022414
GO:0023052
GO:0030054
GO:0030154
GO:0030168
GO:0030198
GO:0030335
GO:0030949
GO:0031092
GO:0031258
GO:0031410
GO:0031527
GO:0031528
GO:0031589
GO:0031994
GO:0032147
GO:0032369
GO:0032587
GO:0032880
GO:0032956
GO:0032991
GO:0033627
GO:0033630
GO:0033690
GO:0034113
GO:0034330
GO:0034446
GO:0034683
GO:0035295
GO:0035866
GO:0035867
GO:0035868
GO:0036119
GO:0036120
GO:0036211
GO:0038027
GO:0038132
GO:0042060
GO:0042470
GO:0042802
GO:0042995
GO:0043184
GO:0043226
GO:0043235
GO:0043277
GO:0045124
GO:0045202
GO:0045211
GO:0045766
GO:0045780
GO:0046718
GO:0048008
GO:0048146
GO:0048333
GO:0048661
GO:0048856
GO:0048870
GO:0050731
GO:0050748
GO:0050839
GO:0050840
GO:0050919
GO:0051279
GO:0051604
GO:0051611
GO:0055065
GO:0055085
GO:0060055
GO:0060089
GO:0061097
GO:0070051
GO:0070062
GO:0070161
GO:0070374
GO:0070527
GO:0071062
GO:0071133
GO:0071260
GO:0071466
GO:0072126
GO:0072378
GO:0097060
GO:0098690
GO:0098880
GO:0098978
GO:0099149
GO:0140096
GO:0150054
GO:1900026
GO:1900731
GO:1901163
GO:1903053
GO:1905598
GO:1990314
GO:2000352
GO:2000406
HMNXSV003022425
Hs.225198.0.A1_3p_at
Hs.87149.0.A1_3p_a_at
Hs.87149.2.A1_3p_a_at
Hs.87149.3.A1_3p_at
ILMN_1733324
M35999_at
PH_hs_0004893
PH_hs_0012597
TC17002878.hg
g183452_3p_a_at
g183532_3p_a_at
g4557676_3p_a_at
Participates
as a component of
Alpha IIb Beta 3 Integrin [platelet alpha granule membrane] (Homo sapiens)
Other forms of this molecule
p-T779-ITGB3 [plasma membrane]
ITGB3 [plasma membrane]
Inferred To
Homologues of ITGB3(27-?) [platelet alpha granule membrane]
(Caenorhabditis elegans)
Homologues of ITGB3(27-?) [platelet alpha granule membrane]
(Drosophila melanogaster)
itgb3 [platelet alpha granule membrane]
(Xenopus tropicalis)
itgb3.1 [platelet alpha granule membrane]
(Danio rerio)
mys [platelet alpha granule membrane]
(Drosophila melanogaster)
ITGB3(27-?) [platelet alpha granule membrane]
(Caenorhabditis elegans)
ITGB3(27-?) [platelet alpha granule membrane]
(Gallus gallus)
ITGB3(27-?) [platelet alpha granule membrane]
(Mus musculus)
ITGB3(27-?) [platelet alpha granule membrane]
(Rattus norvegicus)
Itgbn [platelet alpha granule membrane]
(Drosophila melanogaster)
pat-3 [platelet alpha granule membrane]
(Caenorhabditis elegans)
ITGB3 [platelet alpha granule membrane]
(Bos taurus)
ITGB3 [platelet alpha granule membrane]
(Canis familiaris)
ITGB3 [platelet alpha granule membrane]
(Sus scrofa)
Cross References
RefSeq
NP_000203.2
Guide to Pharmacology - Targets
2457
OpenTargets
ENSG00000259207
HPA
ENSG00000259207-ITGB3
GeneCards
P05106
Ensembl
ENSP00000513002
,
ENSP00000452786
,
ENST00000559488
,
ENSG00000259207
,
ENST00000696963
PRO
P05106
Pharos - Targets
P05106
Orphanet
16274
PDB
7UK9
,
1KUP
,
2Q6W
,
6AVR
,
1U8C
,
1MIZ
,
4MMX
,
4MMY
,
2K9J
,
4Z7Q
,
7TMZ
,
3FCU
,
7LA4
,
2VDQ
,
6BXF
,
6BXJ
,
2VDP
,
7KN0
,
4MMZ
,
7L8P
,
7UKO
,
7TPD
,
6MSL
,
4CAK
,
7U9F
,
2VDO
,
7U60
,
6MSU
,
1MK9
,
2VDN
,
7UFH
,
2L1C
,
7UE0
,
1KUZ
,
2RN0
,
3T3M
,
2VDM
,
2KNC
,
7UKT
,
6MK0
,
4G1E
,
3ZE2
,
4Z7N
,
3NIF
,
6NAJ
,
6BXB
,
2L91
,
4Z7O
,
1M1X
,
7U9V
,
3T3P
,
1JV2
,
7TD8
,
4G1M
,
2KV9
,
2LJF
,
6CKB
,
7TCT
,
2LJE
,
3NIG
,
6AVU
,
3FCS
,
1TYE
,
3IJE
,
7UBR
,
7UDG
,
7UH8
,
1L5G
,
2LJD
,
5HDB
,
3ZDX
,
7UDH
,
7THO
,
1MK7
,
7UKP
,
1M8O
,
7UJE
,
3ZDY
,
4O02
,
2RMZ
,
6V4P
,
3ZE0
,
2N9Y
,
3ZDZ
,
2VDL
,
2VDK
,
7UJK
,
3ZE1
,
2MTP
,
3NID
,
7UCY
,
1S4X
,
6AVQ
,
2VC2
,
2VDR
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P26039
2
Tln1 [extracellular region]
(R-MMU-350693)
Tln1 [cytosol]
(R-MMU-350713)
0.842
8
UniProt:P08514 ITGA2B
2
ITGA2B(32-?) [platelet alpha granule membrane]
(R-HSA-114511)
ITGA2B(32-1039) [plasma membrane]
(R-HSA-57578)
0.815
12
UniProt:P02751 FN1
10
FN1(32-2386) [platelet alpha granule lumen]
(R-HSA-114620)
FN1(32-271) [extracellular region]
(R-HSA-3787935)
FN1(272-2386) [extracellular region]
(R-HSA-3788024)
FN1(32-?) [extracellular region]
(R-HSA-2533850)
FN1(?-2386) [extracellular region]
(R-HSA-2533841)
FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane]
(R-HSA-9713462)
FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane]
(R-HSA-9713459)
p-FN1 [endoplasmic reticulum lumen]
(R-HSA-8956937)
FN1 [endoplasmic reticulum lumen]
(R-HSA-8956708)
FN1(32-2386) [extracellular region]
(R-HSA-54851)
0.75
5
UniProt:Q9Y490 TLN1
2
TLN1 [extracellular region]
(R-HSA-350693)
TLN1 [cytosol]
(R-HSA-350713)
0.715
5
UniProt:P78423 CX3CL1
1
CX3CL1 [extracellular region]
(R-HSA-373368)
0.688
6
UniProt:P21333 FLNA
3
FLNA [extracellular region]
(R-HSA-350712)
p-S2152-FLNA [cytosol]
(R-HSA-5669246)
FLNA [cytosol]
(R-HSA-210019)
0.611
3
UniProt:P97465
2
phospho-Dok1 [cytosol]
(R-MMU-8848784)
Dok1 [cytosol]
(R-MMU-74763)
0.602
3
UniProt:Q9QZS3 Numb
2
Numb [plasma membrane]
(R-MMU-2077469)
Numb [plasma membrane]
(R-MMU-443595)
0.544
2
UniProt:P05094
3
ACTN1 [extracellular region]
(R-GGA-349722)
ACTN1 [platelet alpha granule lumen]
(R-GGA-349724)
ACTN1 [cytosol]
(R-GGA-354096)
0.524
2
UniProt:P18031 PTPN1
2
PTPN1 [cytosol]
(R-HSA-210625)
PTPN1 [endosome membrane]
(R-HSA-9815895)
0.499
4
UniProt:P23471 PTPRZ1
2
C4S-PTPRZ1 [plasma membrane]
(R-HSA-9699799)
PTPRZ1 [plasma membrane]
(R-HSA-374561)
0.463
2
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