Reactome | ITGB3(27-?) [platelet alpha granule membrane]

ITGB3(27-?) [platelet alpha granule membrane]

Stable Identifier

R-HSA-114512

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

platelet alpha granule membrane

Synonyms

Integrin beta-3, Platelet membrane glycoprotein IIIa, GPIIIa, CD61 antigen

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P05106 ITGB3

Gene Names

ITGB3, GP3A

Chain

signal peptide:1-26, chain:27-788

Reference Genes

BioGPS Gene:3690 ITGB3

COSMIC (genes):ITGB3 ITGB3

CTD Gene:3690 ITGB3

dbSNP Gene:3690 ITGB3

ENSEMBL:ENSG00000259207 ITGB3

HGNC:6156 ITGB3

KEGG Gene (Homo sapiens):3690 ITGB3

Monarch:3690 ITGB3

NCBI Gene:3690 ITGB3

OMIM:173470 ITGB3

UCSC:P05106 ITGB3

Reference Transcript

RefSeq:NM_000212.2 ITGB3

Other Identifiers

0006420722

11735062_at

11735063_a_at

11735064_at

11735065_a_at

11735066_at

11755065_a_at

16835158

1JV2

1KUP

1KUZ

1L5G

1M1X

1M8O

1MIZ

1MK7

1MK9

1RN0

1S4X

1TYE

1U8C

204625_s_at

204626_s_at

204627_s_at

204628_s_at

27852

2INI

2K9J

2KNC

2KV9

2L1C

2L91

2LJD

2LJE

2LJF

2MTP

2N9Y

2Q6W

2RMZ

2RN0

2VC2

2VDK

2VDL

2VDM

2VDN

2VDO

2VDP

2VDQ

2VDR

3690

3724547

3724552

3724554

3724555

3724556

3724557

3724558

3724559

3724560

3724562

3724563

3724564

3724566

3724569

3724570

3724571

3724572

3724573

3724575

3724576

3724577

37952_at

3FCS

3FCU

3IJE

3NID

3NIF

3NIG

3T3M

3T3P

3ZDX

3ZDY

3ZDZ

3ZE0

3ZE1

3ZE2

4CAK

4G1E

4G1M

4MMX

4MMY

4MMZ

4O02

4Z7N

4Z7O

4Z7Q

5HDB

6AVQ

6AVR

6AVU

6BXB

6BXF

6BXJ

6CKB

8007931

A_14_P115980

A_14_P131651

A_23_P38519

A_24_P318656

AAA16076

AAA20880

AAA35927

AAA36121

AAA52589

AAA52600

AAA60122

AAA67537

AAB23689

AAB71380

AAI27667

AAI27668

BC127666

BC127667

CCDS11511

CH471231

EAW57682

ENSG00000259207

ENSP00000452786

ENST00000559488

ENST00000559488.5

EntrezGene:3690

EntrezGene:ITGB3

g183452_3p_a_at

g183532_3p_a_at

g4557676_3p_a_at

GE57949

GO:0000902

GO:0001618

GO:0001934

GO:0001938

GO:0001968

GO:0002020

GO:0002376

GO:0002576

GO:0003674

GO:0003756

GO:0005161

GO:0005178

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005886

GO:0005887

GO:0005911

GO:0005925

GO:0006464

GO:0006810

GO:0006950

GO:0007155

GO:0007160

GO:0007165

GO:0007229

GO:0007596

GO:0008150

GO:0008283

GO:0008305

GO:0009058

GO:0009790

GO:0009986

GO:0010595

GO:0010745

GO:0010888

GO:0014909

GO:0015026

GO:0015031

GO:0016020

GO:0016021

GO:0016032

GO:0016192

GO:0016477

GO:0016853

GO:0017134

GO:0019899

GO:0019960

GO:0030054

GO:0030154

GO:0030168

GO:0030198

GO:0030949

GO:0031092

GO:0031258

GO:0031410

GO:0031527

GO:0031528

GO:0031589

GO:0031994

GO:0032147

GO:0032369

GO:0032587

GO:0032880

GO:0032991

GO:0033627

GO:0034113

GO:0034446

GO:0034683

GO:0035295

GO:0035866

GO:0035867

GO:0035868

GO:0038027

GO:0038132

GO:0040011

GO:0042060

GO:0042470

GO:0042592

GO:0042802

GO:0042995

GO:0043184

GO:0043226

GO:0043235

GO:0043277

GO:0044403

GO:0045124

GO:0045202

GO:0045211

GO:0045715

GO:0046718

GO:0048010

GO:0048333

GO:0048646

GO:0048856

GO:0048870

GO:0050731

GO:0050748

GO:0050839

GO:0050840

GO:0050900

GO:0050919

GO:0051611

GO:0060055

GO:0070062

GO:0070527

GO:0071062

GO:0098978

GO:0099149

HGNC:6156

HPA027852

Hs.87149.0.A1_3p_a_at

Hs.87149.2.A1_3p_a_at

I3L4X8

ILMN_1661614

ILMN_1733324

IPR002369

IPR012896

IPR013111

IPR014836

IPR015812

IPR016201

IPR027068

IPR032695

IPR033760

IPR036349

IPR036465

IPR040622

ITGB3

ITGB3-201

J02703

L28832

LRG_481

LRG_481t1

M20311

M25108

M32667

M32672

M32673

M32674

M32675

M32680

M32681

M32682

M32685

M32686

M35999

M35999_at

M57481

M57482

M57483

M57484

M57485

M57486

M57487

M57488

M57489

M57490

M57491

M57492

M57493

M57494

MIM:173470

MIM:187800

MIM:273800

MIM:608446

NM_000212

NP_000203

PF00362

PF07965

PF07974

PF08725

PF17205

PF18372

PH_hs_0004893

PR01186

Q16157

S49379

SM00187

SM00423

SM01241

SM01242

TC17002878.hg

U03881

U95204

UPI000013D240

Participant Of

hasComponent

Alpha IIb Beta 3 Integrin [platelet alpha granule membrane]

Other forms of this molecule

p-T779-ITGB3 [plasma membrane]

ITGB3 [plasma membrane]

Inferred To

Homologues of ITGB3(27-?) [platelet alpha granule membrane] (Drosophila melanogaster)

ITGB3(27-?) [platelet alpha granule membrane] (Bos taurus)

ITGB3(27-?) [platelet alpha granule membrane] (Caenorhabditis elegans)

ITGB3(27-?) [platelet alpha granule membrane] (Canis familiaris)

ITGB3(27-?) [platelet alpha granule membrane] (Danio rerio)

ITGB3(27-?) [platelet alpha granule membrane] (Drosophila melanogaster)

ITGB3(27-?) [platelet alpha granule membrane] (Gallus gallus)

ITGB3(27-?) [platelet alpha granule membrane] (Mus musculus)

ITGB3(27-?) [platelet alpha granule membrane] (Rattus norvegicus)

ITGB3(27-?) [platelet alpha granule membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_000203.2

OpenTargets

ENSG00000259207

GeneCards

P05106

PRO

P05106

Orphanet

16274

PDB

2MTP, 6MK0, 2INI, 2VDK, 6CKB, 1KUZ, 3ZE2, 3FCU, 2Q6W, 4Z7Q, 1RN0, 2LJF, 2KV9, 1S4X, 2K9J, 2N9Y, 2RMZ, 2VDM, 3IJE, 2KNC, 4Z7N, 1M8O, 2RN0, 4Z7O, 2VDL, 2VDO, 2VDN, 1MIZ, 1TYE, 3T3M, 2VDQ, 1JV2, 4CAK, 2VDP, 2VC2, 6BXB, 2L91, 3NIF, 6AVR, 4G1E, 1M1X, 3T3P, 3NID, 6BXF, 2VDR, 4O02, 1MK7, 2L1C, 4MMY, 4G1M, 3NIG, 4MMX, 6AVQ, 5HDB, 3ZDX, 1L5G, 1MK9, 6AVU, 2LJE, 3ZE1, 1KUP, 3FCS, 4MMZ, 6BXJ, 1U8C, 3ZDZ, 3ZE0, 3ZDY, 2LJD

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P26039	2	TLN1 [extracellular region] (R-MMU-350693) TLN1 [cytosol] (R-MMU-350713)	0.842	8
UniProt:P02751 FN1	8	FN1(32-271) [extracellular region] (R-HSA-3787935) FN1(32-2386) [platelet alpha granule lumen] (R-HSA-114620) FN1(272-2386) [extracellular region] (R-HSA-3788024) FN1(32-?) [extracellular region] (R-HSA-2533850) FN1(?-2386) [extracellular region] (R-HSA-2533841) p-FN1 [endoplasmic reticulum lumen] (R-HSA-8956937) FN1 [endoplasmic reticulum lumen] (R-HSA-8956708) FN1(32-2386) [extracellular region] (R-HSA-54851)	0.75	5
UniProt:P08514 ITGA2B	2	ITGA2B(32-1039) [plasma membrane] (R-HSA-57578) ITGA2B(32-?) [platelet alpha granule membrane] (R-HSA-114511)	0.75	11
UniProt:P78423 CX3CL1	1	CX3CL1 [extracellular region] (R-HSA-373368)	0.718	7
UniProt:Q9Y490 TLN1	2	TLN1 [cytosol] (R-HSA-350713) TLN1 [extracellular region] (R-HSA-350693)	0.618	4
UniProt:P21333 FLNA	3	p-S2152-FLNA [cytosol] (R-HSA-5669246) FLNA [cytosol] (R-HSA-210019) FLNA [extracellular region] (R-HSA-350712)	0.611	3
UniProt:P97465	2	DOK1 [cytosol] (R-MMU-74763) phospho-p-Y362-DOK1 [cytosol] (R-MMU-8848784)	0.602	3
UniProt:P05480 Src	12	phospho-p-Y419-SRC [cytosol] (R-MMU-377592) SRC-2 [cytosol] (R-MMU-191648) phospho-MyrG-p-Y419-SRC [plasma membrane] (R-MMU-1810408) SRC-1 [plasma membrane] (R-MMU-65043) phospho-MyrG,p-Y530-SRC [plasma membrane] (R-MMU-377598) Src [cytosol] (R-MMU-418782) phospho-p-Y419-SRC-1 [plasma membrane] (R-MMU-112331) MyrG-SRC [plasma membrane] (R-MMU-8876922) MyrG-p-Y424-Src [plasma membrane] (R-MMU-9011258) Activated Src [nucleoplasm] (R-MMU-8937700) phospho-p-Y416-SRC [cytosol] (R-MMU-8964276) SRC [cytosol] (R-MMU-9628701)	0.602	5
UniProt:Q9QZS3 Numb	2	NUMB [plasma membrane] (R-MMU-443595) Numb [plasma membrane] (R-MMU-2077469)	0.544	2
UniProt:P18031 PTPN1	1	PTPN1 [cytosol] (R-HSA-210625)	0.499	4
UniProt:P23471 PTPRZ1	1	PTPRZ1 [plasma membrane] (R-HSA-374561)	0.463	2