Rac1 activation of PI3K

Stable Identifier
R-HSA-114542
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PIP3 produced by PI3K activity is essential for receptor-driven stimulation of Rac activation, but PI3K also lies downstream of Rac, as Rac1 can form a complex with PI3K alpha leading to its activation.

Literature References
PubMed ID Title Journal Year
8645157 Rac GTPase interacts specifically with phosphatidylinositol 3-kinase

Bokoch, GM, Vlahos, CJ, Wang, Y, Knaus, UG, Traynor-Kaplan, AE

Biochem J 1996
11803464 Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaB

Murga, C, Zohar, M, Teramoto, H, Gutkind, JS

Oncogene 2002
7744773 Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation

Kovacsovics, TJ, Bachelot, C, Toker, A, Vlahos, CJ, Duckworth, B, Cantley, LC, Hartwig, JH

J Biol Chem 1995
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Orthologous Events