RAC1,RAC2,RHOG activate PI3K

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PIP3 produced by PI3K activity is essential for receptor-driven stimulation of Rac activation, but PI3K also lies downstream of Rac, as Rac1 can form a complex with PI3K alpha leading to its activation.

Literature References
PubMed ID Title Journal Year
11803464 Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaB

Murga, C, Teramoto, H, Zohar, M, Gutkind, JS

Oncogene 2002
8645157 Rac GTPase interacts specifically with phosphatidylinositol 3-kinase

Knaus, UG, Wang, Y, Bokoch, GM, Traynor-Kaplan, AE, Vlahos, CJ

Biochem J 1996
7744773 Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation

Hartwig, JH, Cantley, LC, Toker, A, Bachelot, C, Duckworth, B, Vlahos, CJ, Kovacsovics, TJ

J Biol Chem 1995
Orthologous Events
Cite Us!