p115-RhoGEF activation of Rac1

Stable Identifier
R-HSA-114544
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

At the beginning of this reaction, 1 molecule of 'GTP', and 1 molecule of 'Deactivated RAC1' are present. At the end of this reaction, 1 molecule of 'Activated RAC1', and 1 molecule of 'GDP' are present.

This reaction is mediated by the 'guanyl-nucleotide exchange factor activity' of 'Activated 115Rho GEF'.

Literature References
PubMed ID Title Journal Year
10648409 Activation of the small GTPases, rac and cdc42, after ligation of the platelet PAR-1 receptor

Azim, AC, Barkalow, K, Chou, J, Hartwig, JH

Blood 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of G13-activated p115-RhoGEF [plasma membrane]
Physical Entity
Activity
Orthologous Events