p115-RhoGEF activation of RHOA

Stable Identifier
R-HSA-114544
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

ARHEF1 (p115-RhoGEF), recruited to the plasma membrane by binding to GTP-bound G-protein alpha (13) (GNA13), stimulates GDP to GTP exchange on RHOA, resulting in activation of the RHOA GTPase (Chen et al. 2012).

Literature References
PubMed ID Title Journal Year
22661716 Activation of p115-RhoGEF requires direct association of G?13 and the Dbl homology domain

Chen, Z, Guo, L, Hadas, J, Gutowski, S, Sprang, SR, Sternweis, PC

J. Biol. Chem. 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of G13-activated p115-RhoGEF [plasma membrane]
Physical Entity
Activity
Orthologous Events