G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)

Stable Identifier
R-HSA-114548
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

p115-RhoGEF is a potent GTPase activating protein (GAP) for both G alpha 12 and G alpha 13 subunits. More importantly, the interaction between activated G alpha 13 (but not G alpha 12) triggers p115-RhoGEF activity. While this pathway may be important in vivo, in prostate-derived PC-3 cells RNAi mediated knockdown of p115-RhoGEF levels had no effect on the response to thrombin (Wang et al. 2004).

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Participant Of
Orthologous Events