G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)

Stable Identifier
R-HSA-114548
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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p115-RhoGEF is a potent GTPase activating protein (GAP) for both G alpha 12 and G alpha 13 subunits. More importantly, the interaction between activated G alpha 13 (but not G alpha 12) triggers p115-RhoGEF activity. While this pathway may be important in vivo, in prostate-derived PC-3 cells RNAi mediated knockdown of p115-RhoGEF levels had no effect on the response to thrombin (Wang et al. 2004).

Literature References
PubMed ID Title Journal Year
11313914 RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?

Fukuhara, S, Chikumi, H, Gutkind, JS

Oncogene 2001
15951850 The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits

Siderovski, DP, Willard, FS

Int J Biol Sci 2005
22661716 Activation of p115-RhoGEF requires direct association of Gα13 and the Dbl homology domain

Chen, Z, Guo, L, Hadas, J, Gutowski, S, Sprang, SR, Sternweis, PC

J. Biol. Chem. 2012
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