Collagen type I binds integrin alpha1beta1, alpha2beta1, alpha10beta1

Stable Identifier
R-HSA-114563
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Integrin alpha1beta1 binds to collagen type IV and VI with higher affinity than to types I-III, whereas alpha2beta1 has a higher affinity for collagen types I-III than for type IV. Integrin alpha10beta1 binds collagen types I, IV, and VI with similar affinities (Tulla et al. 2001). Integrin alpha11beta1 binds preferentially to the fibril-forming collagen types I and II, binding to type III is weaker and collagens IV and VI are poor ligands (Zhang et al. 2003).

Binding to collagen type I occurs at sites corresponding to the six-residue sequence G(F/L)OGER (Knight et al. 1998, 2000, Xu et al. 2000).

Integrin alpha2beta1 is the major platelet collagen receptor (Kunicki et al. 1988). It requires Mg2+ to interact with collagen and may require initiation mediated by the activation of Integrin alphaIIbBeta3 (van de Walle 2007).

Participants
Participant Of
Inferred From
Authored
Reviewed
Created