Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen

Stable Identifier
Reaction [binding]
Homo sapiens
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GPVI receptor has little affinity for soluble forms of collagen but binds collagen fibrils. Recent structural models indicate that each GPVI receptor complex could bind up to 3 collagen fibrils (Jung & Moroi 2008). The Src family kinases Fyn and Lyn constitutively associate with the GPVI-FceRIgamma complex in platelets and initiate platelet activation through phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) in the FceRIgamma chain, leading to binding and activation of the tyrosine kinase Syk. Downstream of Syk, a series of adapter molecules and effectors lead to platelet activation.

Literature References
PubMed ID Title Journal Year
9295288 A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets

Tsuji, M, Ezumi, Y, Arai, M, Takayama, H

J Biol Chem 1997
Participant Of
Orthologous Events
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