PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine

Stable Identifier
R-HSA-1168373
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
Protein Kinase C beta (PKC-beta, PRKCB) is activated
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Human Protein kinase C beta (PKC-beta) is activated by calcium ions, diacylglycerol, and binds phosphatidylserine (Kochs et al. 1991). Experiments in mice have shown that knocking out PKC-beta causes severe defects in B cells, leading to the conclusion that PKC-beta is the predominant signaling PKC in these cells (Leitges et al. 1996, Su et al. 2002, Saijo et al. 2002).

Literature References
PubMed ID Title Journal Year
12118249 PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling

Su, TT, Guo, B, Kawakami, Y, Sommer, K, Chae, K, Humphries, LA, Kato, RM, Kang, S, Patrone, L, Wall, R, Teitell, M, Leitges, M, Kawakami, T, Rawlings, DJ

Nat Immunol 2002
8387275 Activation of purified human protein kinase C alpha and beta I isoenzymes in vitro by Ca2+, phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate

Kochs, G, Hummel, R, Fiebich, B, Sarre, TF, Marmé, D, Hug, H

Biochem J 1993
12070292 Protein kinase C beta controls nuclear factor kappaB activation in B cells through selective regulation of the IkappaB kinase alpha

Saijo, K, Mecklenbräuker, I, Santana, A, Leitger, M, Schmedt, C, Tarakhovsky, A

J Exp Med 2002
8670417 Immunodeficiency in protein kinase cbeta-deficient mice

Leitges, M, Schmedt, C, Guinamard, R, Davoust, J, Schaal, S, Stabel, S, Tarakhovsky, A

Science 1996
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