PTP1B binds the GH receptor complex

Stable Identifier
R-HSA-1168445
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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PTP1B has been shown to associate with GH-dependent phosphorylated GHR and induce its dephosphorylation (Pasquali et al. 2003). It can also dephosphorylate JAK2 (Gu et al. 2003). Both have the effect of reducing JAK signaling.

Literature References
PubMed ID Title Journal Year
12907755 Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor

Pasquali, C, Curchod, ML, Wälchli, S, Espanel, X, Guerrier, M, Arigoni, F, Strous, G, Hooft van Huijsduijnen, R

Mol Endocrinol 2003
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created