Reactome: A Curated Pathway Database

PTP1B binds the GH receptor complex

Stable Identifier
R-HSA-1168445
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PTP1B has been shown to associate with GH-dependent phosphorylated GHR and induce its dephosphorylation (Pasquali et al. 2003). It can also dephosphorylate JAK2 (Gu et al. 2003). Both have the effect of reducing JAK signaling.

Literature References
Participants
Participant Of
Orthologous Events