Reactome: A Curated Pathway Database

Lyn activates ERK

Stable Identifier
R-HSA-1168459
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The activation of Lyn by GHR is thought to indirectly activate ERK. Mutations of GHR predicted to disable a conformational change brought about by GH binding impaired ERK signaling but not JAK2/STAT5 signaling. ERK signaling was demonstrated to involve the Src family kinase Lyn (Rowlinson et al. 2008) and suggested to involve Src kinase dependent activation of Phospholipase C gamma and thereby Ras, similar to a mechanism proposed by Bivona et al. (2003). ERK activation mechanisms involving Src kinases and PLCgamma have been reported for the erythropoietin, thrombopoietin and prolactin receptors (Brooks & Waters 2010).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
non-membrane spanning protein tyrosine kinase activity of Growth Hormone:Growth Hormone Receptor-JAK2 dimer:LYN [plasma membrane] Growth Hormone:Growth Hormone Receptor-JAK2 dimer:LYN [plasma membrane] non-membrane spanning protein tyrosine kinase activity (0004715)
Orthologous Events