Lyn activates ERK

Stable Identifier
R-HSA-1168459
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
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The activation of Lyn by GHR is thought to indirectly activate ERK. Mutations of GHR predicted to disable a conformational change brought about by GH binding impaired ERK signaling but not JAK2/STAT5 signaling. ERK signaling was demonstrated to involve the Src family kinase Lyn (Rowlinson et al. 2008) and suggested to involve Src kinase dependent activation of Phospholipase C gamma and thereby Ras, similar to a mechanism proposed by Bivona et al. (2003). ERK activation mechanisms involving Src kinases and PLCgamma have been reported for the erythropoietin, thrombopoietin and prolactin receptors (Brooks & Waters 2010).

Literature References
PubMed ID Title Journal Year
18488018 An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway

Rowlinson, SW, Yoshizato, H, Barclay, JL, Brooks, AJ, Behncken, SN, Kerr, LM, Millard, K, Palethorpe, K, Nielsen, K, Clyde-Smith, J, Hancock, JF, Waters, MJ

Nat Cell Biol 2008
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Catalyst Activity
Title
non-membrane spanning protein tyrosine kinase activity of Growth Hormone:Growth Hormone Receptor-JAK2 dimer:LYN [plasma membrane]
Physical Entity
Activity
Orthologous Events
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