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p-S157,S161-NFKBIE [cytosol]
Stable Identifier
R-HSA-1168561
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-S157,161-IKBE, Phospho-NF-kappa-B inhibitor epsilon, NFKBIE, IKBE_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Activation of NF-kappaB in B cells (Homo sapiens)
Activated IKK phosphorylates I-kappaB (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S157,S161-NFKBIE [cytosol] (Homo sapiens)
NF-kappaB p50:p65:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S157,S161-NFKBIE [cytosol] (Homo sapiens)
NF-kappaB p65:p65:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S157,S161-NFKBIE [cytosol] (Homo sapiens)
SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S157,S161-NFKBIE [cytosol] (Homo sapiens)
NF-kappaB p50:p65:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S157,S161-NFKBIE [cytosol] (Homo sapiens)
NF-kappaB p65:p65:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S157,S161-NFKBIE [cytosol] (Homo sapiens)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S157,S161-NFKBIE [cytosol] (Homo sapiens)
NF-kappaB p50:p65:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S157,S161-NFKBIE [cytosol] (Homo sapiens)
NF-kappaB p65:p65:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S157,S161-NFKBIE [cytosol] (Homo sapiens)
SCF-beta-TrCP ubiquitinylates IkB (Homo sapiens)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S157,S161-NFKBIE [cytosol] (Homo sapiens)
NF-kappaB p50:p65:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S157,S161-NFKBIE [cytosol] (Homo sapiens)
NF-kappaB p65:p65:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S157,S161-NFKBIE [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00221 NFKBIE
Gene Names
NFKBIE, IKBE
Chain
chain:1-500
Reference Genes
BioGPS Gene:4794 NFKBIE
COSMIC (genes):NFKBIE NFKBIE
CTD Gene:4794 NFKBIE
dbSNP Gene:4794 NFKBIE
ENSEMBL:ENSG00000146232 NFKBIE
ENSEMBL:ENSG00000146232.17 NFKBIE
HGNC:7799 NFKBIE
KEGG Gene (Homo sapiens):4794 NFKBIE
Monarch:4794 NFKBIE
NCBI Gene:4794 NFKBIE
OMIM:604548 NFKBIE
UCSC:O00221 NFKBIE
Reference Transcript
RefSeq:NM_004556.2 NFKBIE
Other Identifiers
11743007_at
17019565
203927_PM_at
203927_at
2955074
2955075
2955077
2955078
2955079
2955080
2955081
2955082
2955084
2955085
2955086
2955088
2955090
2955091
2955092
2955093
38276_at
4794
53701_at
7896696
7896713
8126666
A_23_P30655
GE81408
GO:0001650
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0042994
GO:0043226
HMNXSV003038089
ILMN_1717313
PH_hs_0026336
TC06001762.hg
U91616_at
g4758805_3p_at
Participates
as a member of
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
Other forms of this molecule
p-S157,S161-Ub-NFKBIE [cytosol]
NFKBIE [cytosol]
Inferred To
phospho-Nfkbie [cytosol]
(Mus musculus)
phospho-Nfkbie [cytosol]
(Rattus norvegicus)
phospho-NFKBIE [cytosol]
(Bos taurus)
phospho-NFKBIE [cytosol]
(Sus scrofa)
phospho-p-S157,S161-NFKBIE [cytosol]
(Danio rerio)
Modified Residues
Name
O-phospho-L-serine at 157
Coordinate
157
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 161
Coordinate
161
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_004547.2
OpenTargets
ENSG00000146232
HPA
ENSG00000146232-NFKBIE
GeneCards
O00221
Ensembl
ENST00000275015
,
ENSP00000275015
,
ENSG00000146232
PRO
O00221
Pharos - Targets
O00221
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19838 NFKB1
8
NFKB1(1-968) [secretory granule lumen]
(R-HSA-6801004)
NFKB1(1-968) [extracellular region]
(R-HSA-6806304)
NFKB1(1-968) [specific granule lumen]
(R-HSA-6799557)
NFKB1(1-433) [cytosol]
(R-HSA-168168)
NFKB1(1-433) [nucleoplasm]
(R-HSA-177655)
NFKB1(1-968) [cytosol]
(R-HSA-451607)
p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451611)
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451619)
0.604
3
UniProt:Q01201 RELB
2
RELB [nucleoplasm]
(R-HSA-5607656)
RELB [cytosol]
(R-HSA-5607652)
0.564
2
UniProt:Q04206 RELA
6
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
RELA [cytosol]
(R-HSA-168172)
RELA [nucleoplasm]
(R-HSA-177676)
0.488
2
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