Reactome | p-S157,S161-Ub-NFKBIE [cytosol]

p-S157,S161-Ub-NFKBIE [cytosol]

Stable Identifier

R-HSA-1168563

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ub-K-p-S157,161-IKBE, Ubiquitinated Phospho-NF-kappa-B inhibitor epsilon, NFKBIE, IKBE_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O00221 NFKBIE

Gene Names

NFKBIE, IKBE

Chain

chain:1-500

Reference Genes

BioGPS Gene:4794 NFKBIE

COSMIC (genes):NFKBIE NFKBIE

CTD Gene:4794 NFKBIE

dbSNP Gene:4794 NFKBIE

ENSEMBL:ENSG00000146232 NFKBIE

HGNC:7799 NFKBIE

KEGG:hsa:4794 NFKBIE

Monarch:4794 NFKBIE

NCBI Gene:4794 NFKBIE

OMIM:604548 NFKBIE

UCSC:O00221 NFKBIE

Reference Transcript

RefSeq:NM_004556.2 NFKBIE

Other Identifiers

11743007_at

17019565

203927_PM_at

203927_at

2955074

2955075

2955077

2955078

2955079

2955080

2955081

2955082

2955084

2955085

2955086

2955087

2955088

2955090

2955091

2955092

2955093

38276_at

4794

53701_at

7896696

7896713

8126666

A_23_P30655

GE81408

GO:0001650

GO:0005515

GO:0005654

GO:0005737

GO:0005829

GO:0006355

GO:0042942

GO:0042994

GO:0048471

GO:0055085

HMNXSV003038089

ILMN_1717313

PH_hs_0026336

TC06001762.hg

U91616_at

g4758805_3p_at

Participates

as a member of

ub-p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)

as a component of

NF-kappaB p65:p65:ub-p-IkB [cytosol] (Homo sapiens)

Other forms of this molecule

NFKBIE [cytosol]

p-S157,S161-NFKBIE [cytosol]

Inferred To

phospho-Nfkbie [cytosol] (Rattus norvegicus)

phospho-Potefam3d [cytosol] (Mus musculus)

phospho-NFKBIE [cytosol] (Bos taurus)

phospho-NFKBIE [cytosol] (Canis familiaris)

phospho-Charon [cytosol] (Drosophila melanogaster)

phospho-nfkbie [cytosol] (Danio rerio)

phospho-p-S157,S161-Ub-NFKBIE [cytosol] (Sus scrofa)

Homologues of p-S157,S161-Ub-NFKBIE [cytosol] (Mus musculus)

phospho-Potefam3c [cytosol] (Mus musculus)

Modified Residues

Name

O-phospho-L-serine at 157

Coordinate

157

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 161

Coordinate

161

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position

Modification

K48polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_004547.2

ENSEMBL

ENST00000275015, ENSP00000275015

OpenTargets

ENSG00000146232

HPA

ENSG00000146232-NFKBIE

PRO

O00221

Pharos - Targets

O00221

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q01201 RELB	2	RELB [nucleoplasm] (R-HSA-5607656) RELB [cytosol] (R-HSA-5607652)	0.669	4
UniProt:Q04206 RELA	7	RELA [nucleoplasm] (R-HSA-177676) RELA [cytosol] (R-HSA-168172) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S536-RELA [nucleoplasm] (R-HSA-9861499) MeK310-RELA [nucleoplasm] (R-HSA-8865233)	0.621	3
UniProt:P19838 NFKB1	8	3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) NFKB1(1-968) [cytosol] (R-HSA-451607) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004)	0.604	3