Reactome | p-S19,S23-Ub-NFKBIB [cytosol]

p-S19,S23-Ub-NFKBIB [cytosol]

Stable Identifier

R-HSA-1168571

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ub-K-p-S19,23-IKBB, Ubiquitinated Phospho-IkBB, NF-kappaB inhibitor beta(phosphorylated)

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q15653 NFKBIB

Gene Names

NFKBIB, IKBB, TRIP9

Chain

chain:1-356

Reference Genes

BioGPS Gene:4793 NFKBIB

COSMIC (genes):NFKBIB NFKBIB

CTD Gene:4793 NFKBIB

dbSNP Gene:4793 NFKBIB

ENSEMBL:ENSG00000104825 NFKBIB

HGNC:7798 NFKBIB

KEGG:hsa:4793 NFKBIB

Monarch:4793 NFKBIB

NCBI Gene:4793 NFKBIB

OMIM:604495 NFKBIB

UCSC:Q15653 NFKBIB

Reference Transcript

Other Identifiers

11725835_at

11725836_x_at

11745604_x_at

11745832_a_at

16861895

214062_3p_x_at

214062_PM_x_at

214062_x_at

214448_3p_x_at

214448_PM_x_at

214448_x_at

228388_3p_at

228388_PM_at

228388_at

3832761

3832763

3832764

3832765

3832767

3832768

3832769

3832770

3832771

3832772

3832773

3832774

41065_at

43069_at

4793

8028552

A_23_P330895

A_23_P79086

A_24_P161086

A_33_P3343545

GE81164

GE87209

GO:0003713

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006954

GO:0007165

GO:0043122

GO:0043226

GO:0045893

GO:0060090

GO:0071222

GO:0140110

HMNXSV003016327

HMNXSV003028472

HMNXSV003035878

Hs.9731.0.S1_3p_a_at

Hs.9731.0.S1_3p_at

Hs.9731.0.S1_3p_x_at

Hs.9731.1.S1_3p_a_at

Hs.9731.1.S1_3p_at

Hs.9731.1.S1_3p_x_at

ILMN_1674152

ILMN_1690473

ILMN_1712754

L40407_at

PH_hs_0030976

TC19000534.hg

TC19002129.hg

p34312

Participates

as a member of

ub-p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)

Other forms of this molecule

p-S19,S23-NFKBIB [cytosol]

NFKBIB [cytosol]

Inferred To

phospho-p-S19,S23-Ub-NFKBIB [cytosol] (Gallus gallus)

phospho-p-S19,S23-Ub-NFKBIB [cytosol] (Sus scrofa)

phospho-NFKBIB [cytosol] (Bos taurus)

phospho-NFKBIB [cytosol] (Canis familiaris)

phospho-Nfkbib [cytosol] (Mus musculus)

Modified Residues

Name

O-phospho-L-serine at 19

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 23

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position

Modification

K48polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

ENSEMBL

ENSG00000282905, ENST00000313582, ENSP00000489138, ENST00000635517, ENST00000634647, ENSP00000459728, ENSP00000312988, ENSG00000104825, ENSP00000489145, ENST00000572515

OpenTargets

ENSG00000104825

GeneCards

NFKBIB

HPA

ENSG00000104825-NFKBIB

PRO

Q15653

Pharos - Targets

Q15653

PDB

9CK0

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q04206 RELA	7	RELA [nucleoplasm] (R-HSA-177676) RELA [cytosol] (R-HSA-168172) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S536-RELA [nucleoplasm] (R-HSA-9861499) MeK310-RELA [nucleoplasm] (R-HSA-8865233)	0.85	9
UniProt:P19838 NFKB1	8	3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) NFKB1(1-968) [cytosol] (R-HSA-451607) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557)	0.763	6
UniProt:O14920 IKBKB	3	IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506) IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518)	0.564	2
UniProt:Q9Y6K9 IKBKG	12	IKBKG [cytosol] (R-HSA-168108) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-IKBKG [cytosol] (R-HSA-202530) IKBKG [nucleoplasm] (R-HSA-4755413) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG D406V [cytosol] (R-HSA-5262943)	0.564	2
UniProt:Q9GZS1 POLR1E	1	POLR1E [nucleoplasm] (R-HSA-5419294)	0.564	2
UniProt:P25963 NFKBIA	9	NFKBIA [cytosol] (R-HSA-168151) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA [nucleoplasm] (R-HSA-4656929) monoSUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805) PolyUb-NFKBIA [cytosol] (R-HSA-6782960)	0.564	2
UniProt:P20226 TBP	1	TBP [nucleoplasm] (R-HSA-83718)	0.564	3
UniProt:Q00653 NFKB2	6	NFKB2(1-454) [nucleoplasm] (R-HSA-177674) NFKB2(1-454) [cytosol] (R-HSA-168144) p-7S-p100 [cytosol] (R-HSA-5607629) K48-polyUb-p-7S-p100 [cytosol] (R-HSA-5607636) NFKB2(1-900) [cytosol] (R-HSA-2677931) monoSUMO1-K90,K298,K689,K863-NFKB2(1-900) [cytosol] (R-HSA-4755500)	0.564	4
UniProt:O15111 CHUK	4	CHUK [cytosol] (R-HSA-168104) p-S176,S180-CHUK [cytosol] (R-HSA-177667) p-T23-CHUK [cytosol] (R-HSA-198615) p-Y187,Y198-CHUK [cytosol] (R-HSA-9861501)	0.564	3

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