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p-S19,S23-Ub-NFKBIB [cytosol]
Stable Identifier
R-HSA-1168571
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
ub-K-p-S19,23-IKBB, Ubiquitinated Phospho-IkBB, NF-kappaB inhibitor beta(phosphorylated)
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Activation of NF-kappaB in B cells (Homo sapiens)
SCF-beta-TrCP ubiquitinylates IkB (Homo sapiens)
NF-kappaB p50,p65,c-Rel:ub-p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel:ub-p-IKB [cytosol] (Homo sapiens)
ub-p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S19,S23-Ub-NFKBIB [cytosol] (Homo sapiens)
NF-kappaB p50:p65:ub-p-IKB [cytosol] (Homo sapiens)
ub-p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S19,S23-Ub-NFKBIB [cytosol] (Homo sapiens)
Ubiquitinated IkB is degraded (Homo sapiens)
NF-kappaB p50,p65,c-Rel:ub-p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel:ub-p-IKB [cytosol] (Homo sapiens)
ub-p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S19,S23-Ub-NFKBIB [cytosol] (Homo sapiens)
NF-kappaB p50:p65:ub-p-IKB [cytosol] (Homo sapiens)
ub-p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S19,S23-Ub-NFKBIB [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15653 NFKBIB
Gene Names
NFKBIB, IKBB, TRIP9
Chain
chain:1-356
Reference Genes
BioGPS Gene:4793 NFKBIB
COSMIC (genes):NFKBIB NFKBIB
CTD Gene:4793 NFKBIB
dbSNP Gene:4793 NFKBIB
ENSEMBL:ENSG00000104825 NFKBIB
ENSEMBL:ENSG00000104825.17 NFKBIB
ENSEMBL:ENSG00000282905.2 NFKBIB
HGNC:7798 NFKBIB
KEGG Gene (Homo sapiens):4793 NFKBIB
Monarch:4793 NFKBIB
NCBI Gene:4793 NFKBIB
OMIM:604495 NFKBIB
UCSC:Q15653 NFKBIB
Reference Transcript
RefSeq:NM_001243116.1 NFKBIB
RefSeq:NM_002503.4 NFKBIB
Other Identifiers
11725835_at
11725836_x_at
11745604_x_at
11745832_a_at
16861895
214062_3p_x_at
214062_PM_x_at
214062_x_at
214448_3p_x_at
214448_PM_x_at
214448_x_at
228388_3p_at
228388_PM_at
228388_at
3832763
3832764
3832765
3832767
3832768
3832769
3832770
3832771
3832772
3832773
3832774
41065_at
43069_at
4793
8028552
A_23_P330895
A_23_P79086
A_24_P161086
A_33_P3343545
GE81164
GE87209
GO:0003713
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006954
GO:0007165
GO:0007253
GO:0023052
GO:0043122
GO:0043226
GO:0045893
GO:0071222
GO:0140110
HMNXSV003016327
HMNXSV003028472
HMNXSV003035878
Hs.9731.0.S1_3p_a_at
Hs.9731.0.S1_3p_at
Hs.9731.0.S1_3p_x_at
Hs.9731.1.S1_3p_a_at
Hs.9731.1.S1_3p_x_at
ILMN_1674152
ILMN_1712754
L40407_at
PH_hs_0030976
TC19000534.hg
TC19002129.hg
p34312
Participates
as a member of
ub-p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
Other forms of this molecule
p-S19,S23-NFKBIB [cytosol]
NFKBIB [cytosol]
Inferred To
phospho-nfkbie [cytosol]
(Xenopus tropicalis)
phospho-p-S19,S23-Ub-NFKBIB [cytosol]
(Canis familiaris)
phospho-p-S19,S23-Ub-NFKBIB [cytosol]
(Gallus gallus)
phospho-NFKBIB [cytosol]
(Bos taurus)
phospho-NFKBIB [cytosol]
(Sus scrofa)
phospho-Nfkbib [cytosol]
(Mus musculus)
Modified Residues
Name
O-phospho-L-serine at 19
Coordinate
19
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 23
Coordinate
23
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_001230045.1
,
NP_002494.2
OpenTargets
ENSG00000104825
HPA
ENSG00000104825-NFKBIB
GeneCards
Q15653
Ensembl
ENSP00000489145
,
ENST00000313582
,
ENST00000572515
,
ENSG00000104825
,
ENST00000634647
,
ENST00000635517
,
ENSP00000489138
,
ENSG00000282905
,
ENSP00000312988
,
ENSP00000459728
PRO
Q15653
Pharos - Targets
Q15653
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q04206 RELA
6
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
RELA [cytosol]
(R-HSA-168172)
RELA [nucleoplasm]
(R-HSA-177676)
0.75
6
UniProt:P19838 NFKB1
8
NFKB1(1-968) [secretory granule lumen]
(R-HSA-6801004)
NFKB1(1-968) [extracellular region]
(R-HSA-6806304)
NFKB1(1-968) [specific granule lumen]
(R-HSA-6799557)
NFKB1(1-433) [cytosol]
(R-HSA-168168)
NFKB1(1-433) [nucleoplasm]
(R-HSA-177655)
NFKB1(1-968) [cytosol]
(R-HSA-451607)
p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451611)
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451619)
0.604
3
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