Reactome | p-S19,S23-Ub-NFKBIB [cytosol]

p-S19,S23-Ub-NFKBIB [cytosol]

Stable Identifier

R-HSA-1168571

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ub-K-p-S19,23-IKBB, Ubiquitinated Phospho-IkBB, NF-kappaB inhibitor beta(phosphorylated)

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q15653 NFKBIB

Gene Names

NFKBIB, IKBB, TRIP9

Chain

chain:1-356

Reference Genes

BioGPS Gene:4793 NFKBIB

COSMIC (genes):NFKBIB NFKBIB

CTD Gene:4793 NFKBIB

dbSNP Gene:4793 NFKBIB

ENSEMBL:ENSG00000104825 NFKBIB

ENSEMBL:ENSG00000104825.17 NFKBIB

ENSEMBL:ENSG00000282905.2 NFKBIB

HGNC:7798 NFKBIB

KEGG Gene (Homo sapiens):4793 NFKBIB

Monarch:4793 NFKBIB

NCBI Gene:4793 NFKBIB

OMIM:604495 NFKBIB

UCSC:Q15653 NFKBIB

Reference Transcript

Other Identifiers

11725835_at

11725836_x_at

11745604_x_at

11745832_a_at

16861895

214062_3p_x_at

214062_PM_x_at

214062_x_at

214448_3p_x_at

214448_PM_x_at

214448_x_at

228388_3p_at

228388_PM_at

228388_at

3832763

3832764

3832765

3832767

3832768

3832769

3832770

3832771

3832772

3832773

3832774

41065_at

43069_at

4793

8028552

A_23_P330895

A_23_P79086

A_24_P161086

A_33_P3343545

GE81164

GE87209

GO:0003713

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006954

GO:0007165

GO:0007253

GO:0023052

GO:0043122

GO:0043226

GO:0045893

GO:0071222

GO:0140110

HMNXSV003016327

HMNXSV003028472

HMNXSV003035878

Hs.9731.0.S1_3p_a_at

Hs.9731.0.S1_3p_at

Hs.9731.0.S1_3p_x_at

Hs.9731.1.S1_3p_a_at

Hs.9731.1.S1_3p_x_at

ILMN_1674152

ILMN_1712754

L40407_at

PH_hs_0030976

TC19000534.hg

TC19002129.hg

p34312

Participates

as a member of

ub-p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)

Other forms of this molecule

p-S19,S23-NFKBIB [cytosol]

NFKBIB [cytosol]

Inferred To

phospho-nfkbie [cytosol] (Xenopus tropicalis)

phospho-p-S19,S23-Ub-NFKBIB [cytosol] (Canis familiaris)

phospho-p-S19,S23-Ub-NFKBIB [cytosol] (Gallus gallus)

phospho-NFKBIB [cytosol] (Bos taurus)

phospho-NFKBIB [cytosol] (Sus scrofa)

phospho-Nfkbib [cytosol] (Mus musculus)

Modified Residues

Name

O-phospho-L-serine at 19

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 23

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position

Modification

K48polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001230045.1, NP_002494.2

OpenTargets

ENSG00000104825

HPA

ENSG00000104825-NFKBIB

GeneCards

Q15653

Ensembl

ENSP00000489145, ENST00000313582, ENST00000572515, ENSG00000104825, ENST00000634647, ENST00000635517, ENSP00000489138, ENSG00000282905, ENSP00000312988, ENSP00000459728

PRO

Q15653

Pharos - Targets

Q15653

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q04206 RELA	6	MeK310-RELA [nucleoplasm] (R-HSA-8865233) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.75	6
UniProt:P19838 NFKB1	8	NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-968) [cytosol] (R-HSA-451607) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) 3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619)	0.604	3