Reactome | REL [cytosol]

REL [cytosol]

Stable Identifier

R-HSA-1168579

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Proto-oncogene c-Rel, REL_HUMAN

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Signaling by the B Cell Receptor (BCR) (Homo sapiens)
    - Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
      - Activation of NF-kappaB in B cells (Homo sapiens)
        
        Activated IKK phosphorylates I-kappaB (Homo sapiens)
        
        NF-kappa-B p50,p65,c-Rel:IKB [cytosol] (Homo sapiens)
        
        NF-kappaB p50:c-Rel:IkB [cytosol] (Homo sapiens)
        
        NF-kappaB p50:c-Rel [cytosol] (Homo sapiens)
        
        REL [cytosol] (Homo sapiens)
        
        NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Homo sapiens)
        
        NF-kappaB p50:c-Rel:p-IKB [cytosol] (Homo sapiens)
        
        NF-kappaB p50:c-Rel [cytosol] (Homo sapiens)
        
        REL [cytosol] (Homo sapiens)
        
        NF-kappaB translocates from the cytosol to the nucleus (Homo sapiens)
        
        NF-kappaB p50,p65,c-Rel dimer [cytosol] (Homo sapiens)
        
        NF-kappaB p50:c-Rel [cytosol] (Homo sapiens)
        
        REL [cytosol] (Homo sapiens)
        
        SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Homo sapiens)
        
        NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Homo sapiens)
        
        NF-kappaB p50:c-Rel:p-IKB [cytosol] (Homo sapiens)
        
        NF-kappaB p50:c-Rel [cytosol] (Homo sapiens)
        
        REL [cytosol] (Homo sapiens)
        
        NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Homo sapiens)
        
        NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Homo sapiens)
        
        NF-kappaB p50:c-Rel:p-IKB [cytosol] (Homo sapiens)
        
        NF-kappaB p50:c-Rel [cytosol] (Homo sapiens)
        
        REL [cytosol] (Homo sapiens)
        
        SCF-beta-TrCP ubiquitinylates IkB (Homo sapiens)
        
        NF-kappaB p50,p65,c-Rel:ub-p-IKB [cytosol] (Homo sapiens)
        
        NF-kappaB p50:c-Rel:ub-p-IKB [cytosol] (Homo sapiens)
        
        NF-kappaB p50:c-Rel [cytosol] (Homo sapiens)
        
        REL [cytosol] (Homo sapiens)
        
        NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Homo sapiens)
        
        NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Homo sapiens)
        
        NF-kappaB p50:c-Rel:p-IKB [cytosol] (Homo sapiens)
        
        NF-kappaB p50:c-Rel [cytosol] (Homo sapiens)
        
        REL [cytosol] (Homo sapiens)
        
        Ubiquitinated IkB is degraded (Homo sapiens)
        
        NF-kappaB p50,p65,c-Rel dimer [cytosol] (Homo sapiens)
        
        NF-kappaB p50:c-Rel [cytosol] (Homo sapiens)
        
        REL [cytosol] (Homo sapiens)
        
        NF-kappaB p50,p65,c-Rel:ub-p-IKB [cytosol] (Homo sapiens)
        
        NF-kappaB p50:c-Rel:ub-p-IKB [cytosol] (Homo sapiens)
        
        NF-kappaB p50:c-Rel [cytosol] (Homo sapiens)
        
        REL [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q04864 REL

Gene Names

REL

Chain

initiator methionine:, chain:2-619

Reference Genes

COSMIC (genes):REL REL

dbSNP Gene:5966 REL

ENSEMBL:ENSG00000162924 REL

Participates

as a component of

NF-kappaB p50:c-Rel [cytosol] (Homo sapiens)

Other forms of this molecule

REL [nucleoplasm]

Inferred To

Rel [cytosol] (Mus musculus)

rel [cytosol] (Xenopus tropicalis)

REL [cytosol] (Bos taurus)

REL [cytosol] (Canis familiaris)

REL [cytosol] (Gallus gallus)

REL [cytosol] (Sus scrofa)

Dif [cytosol] (Drosophila melanogaster)

Homologues of REL [cytosol] (Drosophila melanogaster)

dl [cytosol] (Drosophila melanogaster)

Interactors (43)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P19838 NFKB1	8	3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) NFKB1(1-968) [cytosol] (R-HSA-451607) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004)	0.816	10
UniProt:P25963 NFKBIA	9	NFKBIA [cytosol] (R-HSA-168151) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA [nucleoplasm] (R-HSA-4656929) monoSUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805) PolyUb-NFKBIA [cytosol] (R-HSA-6782960)	0.744	6
UniProt:Q00653 NFKB2	6	NFKB2(1-454) [nucleoplasm] (R-HSA-177674) NFKB2(1-454) [cytosol] (R-HSA-168144) p-7S-p100 [cytosol] (R-HSA-5607629) K48-polyUb-p-7S-p100 [cytosol] (R-HSA-5607636) NFKB2(1-900) [cytosol] (R-HSA-2677931) monoSUMO1-K90,K298,K689,K863-NFKB2(1-900) [cytosol] (R-HSA-4755500)	0.744	6
UniProt:Q8NFZ5 TNIP2	1	TNIP2 [cytosol] (R-HSA-451661)	0.669	3
UniProt:Q04206 RELA	7	RELA [nucleoplasm] (R-HSA-177676) RELA [cytosol] (R-HSA-168172) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S536-RELA [nucleoplasm] (R-HSA-9861499) MeK310-RELA [nucleoplasm] (R-HSA-8865233)	0.659	5
UniProt:Q16236 NFE2L2	13	p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) ub-NFE2L2 [cytosol] (R-HSA-9758077) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736)	0.625	5
UniProt:Q969S2 NEIL2	1	NEIL2 [nucleoplasm] (R-HSA-5649650)	0.556	3
UniProt:Q96LC9 BMF	3	BMF [plasma membrane] (R-HSA-140209) p-BMF(1-89) [cytosol] (R-HSA-140529) p-BMF [mitochondrial outer membrane] (R-HSA-3145026)	0.556	3
UniProt:Q9NQ94 A1CF	1	A1CF [nucleoplasm] (R-HSA-3211440)	0.556	3
UniProt:Q9NQT4 EXOSC5	2	EXOSC5 [cytosol] (R-HSA-429889) EXOSC5 [nucleoplasm] (R-HSA-6791550)	0.556	3
UniProt:Q9UBH0 IL36RN	1	IL36RN [extracellular region] (R-HSA-8940995)	0.556	3
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.556	3
UniProt:Q9Y316 MEMO1	1	MEMO1 [cytosol] (R-HSA-6785630)	0.556	3
UniProt:O95848 NUDT14	1	NUDT14 [cytosol] (R-HSA-6809220)	0.556	3
UniProt:Q7Z3C6 ATG9A	1	ATG9A [phagophore assembly site membrane] (R-HSA-5671732)	0.556	3
UniProt:Q9NSA3 CTNNBIP1	1	CTNNBIP1 [nucleoplasm] (R-HSA-3772388)	0.556	3
UniProt:Q5SY16 NOL9	1	NOL9 [nucleoplasm] (R-HSA-6791216)	0.556	3
UniProt:P21673 SAT1	1	SAT1 [cytosol] (R-HSA-351236)	0.556	3
UniProt:P55957 BID	4	MYS-BID(62-195) [mitochondrial outer membrane] (R-HSA-114266) MYS-BID(62-195) [cytosol] (R-HSA-141373) BID(1-195) [cytosol] (R-HSA-50825) BID(62-195) [cytosol] (R-HSA-139953)	0.556	3
UniProt:P62875 POLR2L	2	POLR2L [cytosol] (R-HSA-1964467) POLR2L [nucleoplasm] (R-HSA-83715)	0.556	3
UniProt:O95602 POLR1A	1	POLR1A [nucleoplasm] (R-HSA-63494)	0.556	3
UniProt:O94979 SEC31A	5	SEC31A [ER to Golgi transport vesicle membrane] (R-HSA-204010) SEC31A [cytosol] (R-HSA-203983) SEC31A [endoplasmic reticulum membrane] (R-HSA-204000) SEC31A(1-989)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713478) SEC31A(1-989)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713475)	0.556	3
UniProt:O60573 EIF4E2	1	EIF4E2 [cytosol] (R-HSA-1678822)	0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:P09917 ALOX5	6	p-S272-ALOX5 [nuclear envelope] (R-HSA-2318765) ALOX5 [cytosol] (R-HSA-429010) ALOX5 [secretory granule lumen] (R-HSA-6801306) ALOX5 [extracellular region] (R-HSA-6806468) ALOX5 [ficolin-1-rich granule lumen] (R-HSA-6801302) p-S272-ALOX5 [cytosol] (R-HSA-265276)	0.556	3
UniProt:Q9Y4Z2 NEUROG3	1	NEUROG3 [nucleoplasm] (R-HSA-189530)	0.556	3
UniProt:Q8IVS8 GLYCTK	1	GLYCTK [cytosol] (R-HSA-6799244)	0.556	3
UniProt:Q6DKK2 TTC19	1	TTC19 [mitochondrial inner membrane] (R-HSA-9906047)	0.556	3
UniProt:Q13541 EIF4EBP1	2	p-T37,T46-EIF4EBP1 [cytosol] (R-HSA-165685) EIF4EBP1 [cytosol] (R-HSA-72580)	0.556	3
UniProt:Q13882 PTK6	5	PTK6 [cytosol] (R-HSA-8848000) p-Y342-PTK6 [cytosol] (R-HSA-8848007) p-Y342-PTK6 [nucleoplasm] (R-HSA-8848937) p-Y351-PTK6 [cytosol] (R-HSA-8857570) p-Y342,Y447-PTK6 [cytosol] (R-HSA-8849103)	0.556	3
UniProt:P48065 SLC6A12	1	SLC6A12 [plasma membrane] (R-HSA-351969)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.556	3
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.556	3
UniProt:Q9UI95 MAD2L2	1	MAD2L2 [nucleoplasm] (R-HSA-59092)	0.556	3
UniProt:O14734 ACOT8	2	ACOT8 [cytosol] (R-HSA-9033134) ACOT8 [peroxisomal matrix] (R-HSA-193426)	0.556	3
UniProt:P98177 FOXO4	8	PolyUb-FOXO4 [nucleoplasm] (R-HSA-6782501) Ac-K-FOXO4 [nucleoplasm] (R-HSA-9617761) EP300-S-S-FOXO4 [nucleoplasm] (R-HSA-9617681) CREBBP-S-S-FOXO4 [nucleoplasm] (R-HSA-9617679) SOH-C481-FOXO4 [nucleoplasm] (R-HSA-9617655) p-T32,S197,S262-FOXO4 [cytosol] (R-HSA-9614415) p-T32,S197,S262-FOXO4 [nucleoplasm] (R-HSA-199314) FOXO4 [nucleoplasm] (R-HSA-5690183)	0.556	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.556	3
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.556	3
UniProt:Q8NFF5 FLAD1	1	FLAD1 [cytosol] (R-HSA-196980)	0.556	3
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.556	3
UniProt:Q9UJK0 TSR3	1	TSR3 [cytosol] (R-HSA-8868776)	0.527	3
UniProt:O14965 AURKA	6	p-T288-AURKA [cytosol] (R-HSA-2574832) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) AURKA [nucleoplasm] (R-HSA-4655443) PolyUb-AURKA [cytosol] (R-HSA-8854040) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367)	0.527	2
UniProt:Q01201 RELB	2	RELB [nucleoplasm] (R-HSA-5607656) RELB [cytosol] (R-HSA-5607652)	0.527	3

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