Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
REL [cytosol]
Stable Identifier
R-HSA-1168579
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Proto-oncogene c-Rel, REL_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Activation of NF-kappaB in B cells (Homo sapiens)
Activated IKK phosphorylates I-kappaB (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel:IkB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel [cytosol] (Homo sapiens)
REL [cytosol] (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel [cytosol] (Homo sapiens)
REL [cytosol] (Homo sapiens)
NF-kappaB translocates from the cytosol to the nucleus (Homo sapiens)
NF-kappaB p50,p65,c-Rel dimer [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel [cytosol] (Homo sapiens)
REL [cytosol] (Homo sapiens)
SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel [cytosol] (Homo sapiens)
REL [cytosol] (Homo sapiens)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel [cytosol] (Homo sapiens)
REL [cytosol] (Homo sapiens)
SCF-beta-TrCP ubiquitinylates IkB (Homo sapiens)
NF-kappaB p50,p65,c-Rel:ub-p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel:ub-p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel [cytosol] (Homo sapiens)
REL [cytosol] (Homo sapiens)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel [cytosol] (Homo sapiens)
REL [cytosol] (Homo sapiens)
Ubiquitinated IkB is degraded (Homo sapiens)
NF-kappaB p50,p65,c-Rel dimer [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel [cytosol] (Homo sapiens)
REL [cytosol] (Homo sapiens)
NF-kappaB p50,p65,c-Rel:ub-p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel:ub-p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel [cytosol] (Homo sapiens)
REL [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q04864 REL
Gene Names
REL
Chain
initiator methionine:1, chain:2-619
Reference Genes
BioGPS Gene:5966 REL
COSMIC (genes):REL REL
CTD Gene:5966 REL
dbSNP Gene:5966 REL
ENSEMBL:ENSG00000162924 REL
HGNC:9954 REL
KEGG:hsa:5966 REL
Monarch:5966 REL
NCBI Gene:5966 REL
OMIM:164910 REL
UCSC:Q04864 REL
Reference Transcript
RefSeq:NM_001291746.2 REL
RefSeq:NM_002908.4 REL
Participates
as a component of
NF-kappaB p50:c-Rel [cytosol] (Homo sapiens)
Other forms of this molecule
REL [nucleoplasm]
Inferred To
Rel [cytosol]
(Mus musculus)
Rel [cytosol]
(Rattus norvegicus)
rel [cytosol]
(Danio rerio)
rel [cytosol]
(Xenopus tropicalis)
REL [cytosol]
(Bos taurus)
REL [cytosol]
(Gallus gallus)
REL [cytosol]
(Sus scrofa)
Dif [cytosol]
(Drosophila melanogaster)
Homologues of REL [cytosol]
(Drosophila melanogaster)
dl [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_002899.1
,
NP_001278675.1
Guide to Pharmacology - Targets
3283
OpenTargets
ENSG00000162924
ENSEMBL
ENST00000295025
,
ENSG00000162924
,
ENSP00000377989
,
ENST00000394479
,
ENSP00000295025
GeneCards
REL
HPA
ENSG00000162924-REL
PRO
Q04864
Pharos - Targets
Q04864
GlyGen
Q04864
Interactors (47)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19838 NFKB1
8
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451619)
p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451611)
NFKB1(1-968) [cytosol]
(R-HSA-451607)
NFKB1(1-433) [nucleoplasm]
(R-HSA-177655)
NFKB1(1-433) [cytosol]
(R-HSA-168168)
NFKB1(1-968) [specific granule lumen]
(R-HSA-6799557)
NFKB1(1-968) [extracellular region]
(R-HSA-6806304)
NFKB1(1-968) [secretory granule lumen]
(R-HSA-6801004)
0.816
10
UniProt:Q00653 NFKB2
6
NFKB2(1-454) [nucleoplasm]
(R-HSA-177674)
NFKB2(1-454) [cytosol]
(R-HSA-168144)
p-7S-p100 [cytosol]
(R-HSA-5607629)
K48-polyUb-p-7S-p100 [cytosol]
(R-HSA-5607636)
NFKB2(1-900) [cytosol]
(R-HSA-2677931)
monoSUMO1-K90,K298,K689,K863-NFKB2(1-900) [cytosol]
(R-HSA-4755500)
0.744
6
UniProt:P25963 NFKBIA
9
NFKBIA [cytosol]
(R-HSA-168151)
p-S32,S36-NFKBIA [cytosol]
(R-HSA-177677)
Ub-K21,22-p-S32,S36-NFKBIA [cytosol]
(R-HSA-1168581)
NFKBIA [nucleoplasm]
(R-HSA-4656929)
monoSUMO1-K21-NFKBIA [nucleoplasm]
(R-HSA-4656935)
NFKBIA S32I [cytosol]
(R-HSA-5228846)
NFKBIA F2_M37del [cytosol]
(R-HSA-9630119)
NFKBIA M37K [cytosol]
(R-HSA-5228805)
PolyUb-NFKBIA [cytosol]
(R-HSA-6782960)
0.744
6
UniProt:Q15653 NFKBIB
3
NFKBIB [cytosol]
(R-HSA-168132)
p-S19,S23-NFKBIB [cytosol]
(R-HSA-177670)
p-S19,S23-Ub-NFKBIB [cytosol]
(R-HSA-1168571)
0.669
5
UniProt:Q8NFZ5 TNIP2
1
TNIP2 [cytosol]
(R-HSA-451661)
0.669
3
UniProt:Q04206 RELA
7
RELA [nucleoplasm]
(R-HSA-177676)
RELA [cytosol]
(R-HSA-168172)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
0.659
5
UniProt:Q16236 NFE2L2
13
p-S40-NFE2L2 [nucleoplasm]
(R-HSA-9715109)
p-S,T-NFE2L2 [nucleoplasm]
(R-HSA-9715110)
p-S40-NFE2L2 [cytosol]
(R-HSA-8932290)
p-S,T-NFE2L2 [cytosol]
(R-HSA-8932311)
NFE2L2 [cytosol]
(R-HSA-201566)
p-S,T-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760033)
p-S40-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760018)
ub-NFE2L2 [cytosol]
(R-HSA-9758077)
ub-p-S335, S338,T-NFE2L2 [nucleoplasm]
(R-HSA-9762055)
ub-p-S40, S335, S338- NFE2L2 [nucleoplasm]
(R-HSA-9762058)
p-S344, S347,T-NFE2L2 [nucleoplasm]
(R-HSA-9762048)
p-S40, S344, S347- NFE2L2 [nucleoplasm]
(R-HSA-9762050)
p-S,T,S558-NFE2L2 [nucleoplasm]
(R-HSA-9795736)
0.625
5
UniProt:Q969S2 NEIL2
1
NEIL2 [nucleoplasm]
(R-HSA-5649650)
0.556
3
UniProt:P55957 BID
4
MYS-BID(61-195) [mitochondrial outer membrane]
(R-HSA-114266)
MYS-BID(61-195) [cytosol]
(R-HSA-141373)
BID(1-195) [cytosol]
(R-HSA-50825)
BID(61-195) [cytosol]
(R-HSA-139953)
0.556
3
UniProt:O94979 SEC31A
5
SEC31A [ER to Golgi transport vesicle membrane]
(R-HSA-204010)
SEC31A [cytosol]
(R-HSA-203983)
SEC31A [endoplasmic reticulum membrane]
(R-HSA-204000)
SEC31A(1-989)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713478)
SEC31A(1-989)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713475)
0.556
3
UniProt:Q9Y4Z2 NEUROG3
1
NEUROG3 [nucleoplasm]
(R-HSA-189530)
0.556
3
UniProt:Q13882 PTK6
5
PTK6 [cytosol]
(R-HSA-8848000)
p-Y342-PTK6 [cytosol]
(R-HSA-8848007)
p-Y351-PTK6 [cytosol]
(R-HSA-8857570)
p-Y342,Y447-PTK6 [cytosol]
(R-HSA-8849103)
p-Y342-PTK6 [nucleoplasm]
(R-HSA-8848937)
0.556
3
UniProt:Q96LC9 BMF
3
BMF [plasma membrane]
(R-HSA-140209)
p-BMF [cytosol]
(R-HSA-140529)
p-BMF [mitochondrial outer membrane]
(R-HSA-3145026)
0.556
3
UniProt:Q9NQ94 A1CF
1
A1CF [nucleoplasm]
(R-HSA-3211440)
0.556
3
UniProt:P48065 SLC6A12
1
SLC6A12 [plasma membrane]
(R-HSA-351969)
0.556
3
UniProt:P98177 FOXO4
8
FOXO4 [nucleoplasm]
(R-HSA-5690183)
p-T32,S197,S262-FOXO4 [nucleoplasm]
(R-HSA-199314)
p-T32,S197,S262-FOXO4 [cytosol]
(R-HSA-9614415)
SOH-C481-FOXO4 [nucleoplasm]
(R-HSA-9617655)
CREBBP-S-S-FOXO4 [nucleoplasm]
(R-HSA-9617679)
EP300-S-S-FOXO4 [nucleoplasm]
(R-HSA-9617681)
Ac-K-FOXO4 [nucleoplasm]
(R-HSA-9617761)
PolyUb-FOXO4 [nucleoplasm]
(R-HSA-6782501)
0.556
3
UniProt:O95602 POLR1A
1
POLR1A [nucleoplasm]
(R-HSA-63494)
0.556
3
UniProt:O60573 EIF4E2
1
EIF4E2 [cytosol]
(R-HSA-1678822)
0.556
3
UniProt:Q9NQT4 EXOSC5
3
EXOSC5 [cytosol]
(R-HSA-429889)
EXOSC5 [nucleoplasm]
(R-HSA-6791550)
EXOSC5 [nucleolus]
(R-HSA-9935829)
0.556
3
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.556
3
UniProt:Q9Y316 MEMO1
1
MEMO1 [cytosol]
(R-HSA-6785630)
0.556
3
UniProt:Q14192 FHL2
1
FHL2 [nucleoplasm]
(R-HSA-561161)
0.556
3
UniProt:Q08117 TLE5
1
AES [nucleoplasm]
(R-HSA-4648963)
0.556
3
UniProt:Q9UBH0 IL36RN
1
IL36RN [extracellular region]
(R-HSA-8940995)
0.556
3
UniProt:P61024 CKS1B
1
CKS1B [nucleoplasm]
(R-HSA-187533)
0.556
3
UniProt:O14734 ACOT8
2
ACOT8 [cytosol]
(R-HSA-9033134)
ACOT8 [peroxisomal matrix]
(R-HSA-193426)
0.556
3
UniProt:Q9UI95 MAD2L2
1
MAD2L2 [nucleoplasm]
(R-HSA-59092)
0.556
3
UniProt:O95848 NUDT14
1
NUDT14 [cytosol]
(R-HSA-6809220)
0.556
3
UniProt:Q495W5 FUT11
1
FUT11 [endoplasmic reticulum membrane]
(R-HSA-9034108)
0.556
3
UniProt:P09917 ALOX5
6
p-S272-ALOX5 [nuclear envelope]
(R-HSA-2318765)
ALOX5 [cytosol]
(R-HSA-429010)
ALOX5 [secretory granule lumen]
(R-HSA-6801306)
ALOX5 [extracellular region]
(R-HSA-6806468)
ALOX5 [ficolin-1-rich granule lumen]
(R-HSA-6801302)
p-S272-ALOX5 [cytosol]
(R-HSA-265276)
0.556
3
UniProt:P62875 POLR2L
2
POLR2L [cytosol]
(R-HSA-1964467)
POLR2L [nucleoplasm]
(R-HSA-83715)
0.556
3
UniProt:Q5SY16 NOL9
1
NOL9 [nucleoplasm]
(R-HSA-6791216)
0.556
3
UniProt:Q8IVS8 GLYCTK
1
GLYCTK [cytosol]
(R-HSA-6799244)
0.556
3
UniProt:Q13541 EIF4EBP1
2
EIF4EBP1 [cytosol]
(R-HSA-72580)
p-T37,T46-EIF4EBP1 [cytosol]
(R-HSA-165685)
0.556
3
UniProt:Q10570 CPSF1
1
CPSF1 [nucleoplasm]
(R-HSA-71989)
0.556
3
UniProt:Q8NFF5 FLAD1
1
FLAD1 [cytosol]
(R-HSA-196980)
0.556
3
UniProt:P21673 SAT1
1
SAT1 [cytosol]
(R-HSA-351236)
0.556
3
UniProt:Q9NSA3 CTNNBIP1
1
CTNNBIP1 [nucleoplasm]
(R-HSA-3772388)
0.556
3
UniProt:O00560 SDCBP
3
SDCBP [cytosol]
(R-HSA-373639)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [extracellular region]
(R-HSA-6806206)
0.556
3
UniProt:Q7Z3C6 ATG9A
1
ATG9A [phagophore assembly site membrane]
(R-HSA-5671732)
0.556
3
UniProt:P25786 PSMA1
2
PSMA1 [cytosol]
(R-HSA-68724)
PSMA1 [nucleoplasm]
(R-HSA-174333)
0.556
3
UniProt:Q6DKK2 TTC19
1
TTC19 [mitochondrial inner membrane]
(R-HSA-9906047)
0.556
3
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.556
3
UniProt:O43791 SPOP
3
SPOP [cytosol]
(R-HSA-9929375)
p-S6-SPOP [cytosol]
(R-HSA-9929374)
SPOP [nucleoplasm]
(R-HSA-5635035)
0.553
6
UniProt:Q9UJK0 TSR3
1
TSR3 [cytosol]
(R-HSA-8868776)
0.527
3
UniProt:O14965 AURKA
6
p-T288-AURKA [cytosol]
(R-HSA-2574832)
AURKA [cytosol]
(R-HSA-174254)
PolyUb-AURKA [cytosol]
(R-HSA-8854040)
AURKA [nucleoplasm]
(R-HSA-4655443)
p-T288-AURKA [nucleoplasm]
(R-HSA-6805089)
SUMO1-K258-AURKA [cytosol]
(R-HSA-4655367)
0.527
2
UniProt:Q01201 RELB
2
RELB [nucleoplasm]
(R-HSA-5607656)
RELB [cytosol]
(R-HSA-5607652)
0.527
3
© 2025
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
