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REL [cytosol]
Stable Identifier
R-HSA-1168579
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Proto-oncogene c-Rel, REL_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Activation of NF-kappaB in B cells (Homo sapiens)
Activated IKK phosphorylates I-kappaB (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel:IkB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel [cytosol] (Homo sapiens)
REL [cytosol] (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel [cytosol] (Homo sapiens)
REL [cytosol] (Homo sapiens)
NF-kappaB translocates from the cytosol to the nucleus (Homo sapiens)
NF-kappaB p50,p65,c-Rel dimer [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel [cytosol] (Homo sapiens)
REL [cytosol] (Homo sapiens)
SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel [cytosol] (Homo sapiens)
REL [cytosol] (Homo sapiens)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel [cytosol] (Homo sapiens)
REL [cytosol] (Homo sapiens)
SCF-beta-TrCP ubiquitinylates IkB (Homo sapiens)
NF-kappaB p50,p65,c-Rel:ub-p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel:ub-p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel [cytosol] (Homo sapiens)
REL [cytosol] (Homo sapiens)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel [cytosol] (Homo sapiens)
REL [cytosol] (Homo sapiens)
Ubiquitinated IkB is degraded (Homo sapiens)
NF-kappaB p50,p65,c-Rel dimer [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel [cytosol] (Homo sapiens)
REL [cytosol] (Homo sapiens)
NF-kappaB p50,p65,c-Rel:ub-p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel:ub-p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel [cytosol] (Homo sapiens)
REL [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q04864 REL
Gene Names
REL
Chain
initiator methionine:1, chain:2-619
Reference Genes
BioGPS Gene:5966 REL
COSMIC (genes):REL REL
CTD Gene:5966 REL
dbSNP Gene:5966 REL
ENSEMBL:ENSG00000162924 REL
ENSEMBL:ENSG00000162924.16 REL
HGNC:9954 REL
KEGG Gene (Homo sapiens):5966 REL
Monarch:5966 REL
NCBI Gene:5966 REL
OMIM:164910 REL
UCSC:Q04864 REL
Reference Transcript
RefSeq:NM_002908.3 REL
RefSeq:NM_001291746.1 REL
Other Identifiers
11736551_x_at
11750334_a_at
16880414
16880428
1856_at
206036_PM_s_at
206036_s_at
228812_PM_at
228812_at
235242_PM_at
235242_at
239486_PM_at
239486_at
2484359
2484360
2484364
2484365
2484368
2484372
2484374
2484375
2484376
2484377
2484378
2484379
2484380
2484381
2484382
2484383
2484388
2484390
2484392
2484393
2484395
2484397
41572_r_at
53578_at
57733_at
5966
69985_at
79007_r_at
8042144
80829_at
A_14_P115770
A_19_P00315755
A_19_P00807145
A_21_P0001863
A_23_P56938
A_32_P177685
GE61112
GE780381
GO:0000785
GO:0000978
GO:0000981
GO:0001228
GO:0002376
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0006954
GO:0007249
GO:0010468
GO:0010629
GO:0023052
GO:0032688
GO:0034097
GO:0038061
GO:0043123
GO:0043226
GO:0043565
GO:0045087
GO:0045944
GO:0071159
GO:0098542
GO:0140110
GO:1901215
HMNXSV003024656
HMNXSV003030281
Hs.188751.0.A1_3p_at
Hs.58066.0.A1_3p_at
Hs.86671.0.A1_3p_at
ILMN_1766085
ILMN_2124064
PH_hs_0003218
PH_hs_0003732
TC02000348.hg
TC02003262.hg
TC02003263.hg
X75042_at
g4506472_3p_at
p21127
p9806
Participates
as a component of
NF-kappaB p50:c-Rel [cytosol] (Homo sapiens)
Other forms of this molecule
REL [nucleoplasm]
Inferred To
Rel [cytosol]
(Drosophila melanogaster)
Rel [cytosol]
(Mus musculus)
rel [cytosol]
(Xenopus tropicalis)
REL [cytosol]
(Bos taurus)
REL [cytosol]
(Canis familiaris)
REL [cytosol]
(Gallus gallus)
REL [cytosol]
(Sus scrofa)
Dif [cytosol]
(Drosophila melanogaster)
Homologues of REL [cytosol]
(Drosophila melanogaster)
dl [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001278675.1
,
NP_002899.1
OpenTargets
ENSG00000162924
GeneCards
Q04864
HPA
ENSG00000162924-REL
Ensembl
ENST00000394479
,
ENSP00000377989
,
ENSP00000295025
,
ENSG00000162924
,
ENST00000295025
PRO
Q04864
Pharos - Targets
Q04864
Interactors (36)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19838 NFKB1
8
NFKB1(1-968) [secretory granule lumen]
(R-HSA-6801004)
NFKB1(1-968) [extracellular region]
(R-HSA-6806304)
NFKB1(1-968) [specific granule lumen]
(R-HSA-6799557)
NFKB1(1-433) [cytosol]
(R-HSA-168168)
NFKB1(1-433) [nucleoplasm]
(R-HSA-177655)
NFKB1(1-968) [cytosol]
(R-HSA-451607)
p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451611)
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451619)
0.695
7
UniProt:P25963 NFKBIA
11
PolyUb-NFKBIA [cytosol]
(R-HSA-6782960)
NFKBIA M37K [cytosol]
(R-HSA-5228805)
NFKBIA F2_M37del [cytosol]
(R-HSA-9630119)
NFKBIA [cytosol]
(R-HSA-168151)
p-S32,S36-NFKBIA [cytosol]
(R-HSA-177677)
K48PolyUb-K21,22-p-S32,S36-IkBA [cytosol]
(R-HSA-5607659)
Ub-K21,22-p-S32,S36-NFKBIA [cytosol]
(R-HSA-1168581)
NFKBIA [nucleoplasm]
(R-HSA-4656929)
monoSUMO1-K21-NFKBIA [nucleoplasm]
(R-HSA-4656935)
Ub-K21,22-p-S32,S36-NFKBIA [cytosol]
(R-HSA-9711050)
NFKBIA S32I [cytosol]
(R-HSA-5228846)
0.669
4
UniProt:Q16236 NFE2L2
13
p-S,T,S558-NFE2L2 [nucleoplasm]
(R-HSA-9795736)
p-S40, S344, S347- NFE2L2 [nucleoplasm]
(R-HSA-9762050)
p-S344, S347,T-NFE2L2 [nucleoplasm]
(R-HSA-9762048)
ub-p-S40, S335, S338- NFE2L2 [nucleoplasm]
(R-HSA-9762058)
ub-p-S335, S338,T-NFE2L2 [nucleoplasm]
(R-HSA-9762055)
ub-NFE2L2 [cytosol]
(R-HSA-9758077)
p-S40-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760018)
p-S,T-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760033)
NFE2L2 [cytosol]
(R-HSA-201566)
p-S,T-NFE2L2 [cytosol]
(R-HSA-8932311)
p-S40-NFE2L2 [cytosol]
(R-HSA-8932290)
p-S,T-NFE2L2 [nucleoplasm]
(R-HSA-9715110)
p-S40-NFE2L2 [nucleoplasm]
(R-HSA-9715109)
0.625
5
UniProt:Q8NFZ5 TNIP2
1
TNIP2 [cytosol]
(R-HSA-451661)
0.564
2
UniProt:Q00653 NFKB2
6
monoSUMO1-K90,K298,K689,K863-NFKB2(1-900) [cytosol]
(R-HSA-4755500)
NFKB2(1-900) [cytosol]
(R-HSA-2677931)
K48-polyUb-p-7S-p100 [cytosol]
(R-HSA-5607636)
p-7S-p100 [cytosol]
(R-HSA-5607629)
NFKB2(1-454) [cytosol]
(R-HSA-168144)
NFKB2(1-454) [nucleoplasm]
(R-HSA-177674)
0.564
3
UniProt:Q9NQT4 EXOSC5
2
EXOSC5 [cytosol]
(R-HSA-429889)
EXOSC5 [nucleoplasm]
(R-HSA-6791550)
0.556
3
UniProt:Q96LC9 BMF
3
BMF [plasma membrane]
(R-HSA-140209)
p-BMF(1-89) [cytosol]
(R-HSA-140529)
p-BMF [mitochondrial outer membrane]
(R-HSA-3145026)
0.556
3
UniProt:O14734 ACOT8
2
ACOT8 [cytosol]
(R-HSA-9033134)
ACOT8 [peroxisomal matrix]
(R-HSA-193426)
0.556
3
UniProt:O60573 EIF4E2
1
EIF4E2 [cytosol]
(R-HSA-1678822)
0.556
3
UniProt:O95848 NUDT14
1
NUDT14 [cytosol]
(R-HSA-6809220)
0.556
3
UniProt:Q08117 TLE5
1
AES [nucleoplasm]
(R-HSA-4648963)
0.556
3
UniProt:Q9Y316 MEMO1
1
MEMO1 [cytosol]
(R-HSA-6785630)
0.556
3
UniProt:Q9Y4Z2 NEUROG3
1
NEUROG3 [nucleoplasm]
(R-HSA-189530)
0.556
3
UniProt:Q8NFF5 FLAD1
1
FLAD1 [cytosol]
(R-HSA-196980)
0.556
3
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.556
3
UniProt:Q14192 FHL2
1
FHL2 [nucleoplasm]
(R-HSA-561161)
0.556
3
UniProt:Q13882 PTK6
5
p-Y342-PTK6 [nucleoplasm]
(R-HSA-8848937)
p-Y342,Y447-PTK6 [cytosol]
(R-HSA-8849103)
p-Y351-PTK6 [cytosol]
(R-HSA-8857570)
p-Y342-PTK6 [cytosol]
(R-HSA-8848007)
PTK6 [cytosol]
(R-HSA-8848000)
0.556
3
UniProt:Q13541 EIF4EBP1
2
EIF4EBP1 [cytosol]
(R-HSA-72580)
p-T37,T46-EIF4EBP1 [cytosol]
(R-HSA-165685)
0.556
3
UniProt:O00560 SDCBP
3
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [cytosol]
(R-HSA-373639)
0.556
3
UniProt:P21673 SAT1
1
SAT1 [cytosol]
(R-HSA-351236)
0.556
3
UniProt:Q9UBH0 IL36RN
1
IL36RN [extracellular region]
(R-HSA-8940995)
0.556
3
UniProt:Q5SY16 NOL9
1
NOL9 [nucleoplasm]
(R-HSA-6791216)
0.556
3
UniProt:Q9NQ94 A1CF
1
A1CF [nucleoplasm]
(R-HSA-3211440)
0.556
3
UniProt:P98177 FOXO4
8
FOXO4 [nucleoplasm]
(R-HSA-5690183)
p-T32,S197,S262-FOXO4 [nucleoplasm]
(R-HSA-199314)
p-T32,S197,S262-FOXO4 [cytosol]
(R-HSA-9614415)
SOH-C481-FOXO4 [nucleoplasm]
(R-HSA-9617655)
CREBBP-S-S-FOXO4 [nucleoplasm]
(R-HSA-9617679)
EP300-S-S-FOXO4 [nucleoplasm]
(R-HSA-9617681)
Ac-K-FOXO4 [nucleoplasm]
(R-HSA-9617761)
PolyUb-FOXO4 [nucleoplasm]
(R-HSA-6782501)
0.556
3
UniProt:O95602 POLR1A
1
POLR1A [nucleoplasm]
(R-HSA-63494)
0.556
3
UniProt:P09917 ALOX5
6
p-S272-ALOX5 [cytosol]
(R-HSA-265276)
ALOX5 [secretory granule lumen]
(R-HSA-6801306)
ALOX5 [extracellular region]
(R-HSA-6806468)
ALOX5 [ficolin-1-rich granule lumen]
(R-HSA-6801302)
ALOX5 [cytosol]
(R-HSA-429010)
p-S272-ALOX5 [nuclear envelope]
(R-HSA-2318765)
0.556
3
UniProt:Q8IVS8 GLYCTK
1
GLYCTK [cytosol]
(R-HSA-6799244)
0.556
3
UniProt:Q9NSA3 CTNNBIP1
1
CTNNBIP1 [nucleoplasm]
(R-HSA-3772388)
0.556
3
UniProt:P48065 SLC6A12
1
SLC6A12 [plasma membrane]
(R-HSA-351969)
0.556
3
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.556
3
UniProt:Q9UI95 MAD2L2
1
MAD2L2 [nucleoplasm]
(R-HSA-59092)
0.556
3
UniProt:O94979 SEC31A
5
SEC31A(1-989)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713475)
SEC31A(1-989)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713478)
SEC31A [endoplasmic reticulum membrane]
(R-HSA-204000)
SEC31A [cytosol]
(R-HSA-203983)
SEC31A [ER to Golgi transport vesicle membrane]
(R-HSA-204010)
0.556
3
UniProt:Q969S2 NEIL2
1
NEIL2 [nucleoplasm]
(R-HSA-5649650)
0.556
3
UniProt:P55957 BID
4
MYS-BID(62-195) [mitochondrial outer membrane]
(R-HSA-114266)
MYS-BID(62-195) [cytosol]
(R-HSA-141373)
BID(1-195) [cytosol]
(R-HSA-50825)
BID(62-195) [cytosol]
(R-HSA-139953)
0.556
3
UniProt:P62875 POLR2L
2
POLR2L [nucleoplasm]
(R-HSA-83715)
POLR2L [cytosol]
(R-HSA-1964467)
0.556
3
UniProt:P61024 CKS1B
1
CKS1B [nucleoplasm]
(R-HSA-187533)
0.556
3
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