Ub-21,22-p-S32,S36-NFKBIA [cytosol]

Stable Identifier
R-HSA-1168581
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
ub-K21,22-p-S32,36-IKBA, Ubiquitinated Phospho-IKBA
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
7479976 Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination

Scherer, DC, Brockman, JA, Chen, Z, Maniatis, T, Ballard, DW

Proc Natl Acad Sci U S A 1995
20347421 Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate

Wu, K, Kovacev, J, Pan, ZQ

Mol Cell 2010
External Reference Information
External Reference
UniProt:P25963 NFKBIA
Gene Names
NFKBIA, IKBA, MAD3, NFKBI
Chain
chain:1-317
Reference Genes
BioGPS Gene:4792 NFKBIA
COSMIC (genes):NFKBIA NFKBIA
CTD Gene:4792 NFKBIA
dbSNP Gene:4792 NFKBIA
ENSEMBL:ENSG00000100906 NFKBIA
HGNC:7797 NFKBIA
KEGG Gene (Homo sapiens):4792 NFKBIA
Monarch:4792 NFKBIA
NCBI Gene:4792 NFKBIA
OMIM:164008 NFKBIA
UCSC:P25963 NFKBIA
Reference Transcript
Other Identifiers
0001050280
11744000_a_at
11745878_x_at
11757894_x_at
1461_at
16791991
1IKN
1NFI
201502_s_at
29207
3561040
3561041
3561043
3561044
3561046
3561048
3561050
3561053
3561054
3815
4792
7978644
A_23_P106002
AAA16489
AAH02601
AAH04983
AAK51149
AAP35754
AAR29599
AJ249283
AJ249284
AJ249285
AJ249286
AJ249294
AJ249295
AK313421
AL133163
AY033600
AY496422
BAG36213
BC002601
BC004983
BT007091
CAB003815
CAB65556
CCDS9656
CH471078
EAW65875
ENSG00000100906
ENSP00000216797
ENST00000216797
ENST00000216797.9
EntrezGene:4792
EntrezGene:NFKBIA
G3V286
G3V2A2
G3V3I4
G3V3K1
GE82547
GO:0002376
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006464
GO:0006606
GO:0006810
GO:0006913
GO:0006915
GO:0006950
GO:0007165
GO:0007249
GO:0007253
GO:0008134
GO:0008139
GO:0008150
GO:0008219
GO:0008283
GO:0009058
GO:0010468
GO:0010745
GO:0010875
GO:0010888
GO:0015031
GO:0016032
GO:0016579
GO:0019899
GO:0030154
GO:0031625
GO:0031663
GO:0032088
GO:0032270
GO:0032495
GO:0032496
GO:0032991
GO:0033209
GO:0033256
GO:0034142
GO:0034641
GO:0035994
GO:0042127
GO:0042802
GO:0042994
GO:0043066
GO:0043226
GO:0043330
GO:0043392
GO:0044403
GO:0045638
GO:0045746
GO:0045893
GO:0045944
GO:0048856
GO:0050729
GO:0051059
GO:0070417
GO:0070427
GO:0070431
GO:0070498
GO:0071356
GO:1901222
HGNC:7797
HPA029207
Hs.81328.0.S1_3p_a_at
ILMN_1773154
IPR002110
IPR020683
IPR036770
LRG_89
LRG_89t1
M69043
M69043_at
MIM:164008
MIM:612132
NFKBIA
NFKBIA-201
NM_020529
NP_065390
PF00023
PF12796
PH_hs_0004662
PR01415
SM00248
TC14001036.hg
UPI000004F0A9
Participant Of
hasComponent
hasMember
Other forms of this molecule
PolyUb-NFKBIA [cytosol]
p-S32,S36-NFKBIA [cytosol]
K48PolyUb-K21,22-p-S32,S36-IkBA [cytosol]
NFKBIA [cytosol]
NFKBIA S32I [cytosol]
NFKBIA F2_M37del [cytosol]
NFKBIA M37K [cytosol]
NFKBIA [nucleoplasm]
SUMO1-K21-NFKBIA [nucleoplasm]
Inferred To
phospho-Ub-21,22-p-S32,S36-NFKBIA [cytosol] (Bos taurus)
phospho-Ub-21,22-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
phospho-Ub-21,22-p-S32,S36-NFKBIA [cytosol] (Drosophila melanogaster)
phospho-Ub-21,22-p-S32,S36-NFKBIA [cytosol] (Gallus gallus)
phospho-Ub-21,22-p-S32,S36-NFKBIA [cytosol] (Mus musculus)
phospho-Ub-21,22-p-S32,S36-NFKBIA [cytosol] (Rattus norvegicus)
phospho-Ub-21,22-p-S32,S36-NFKBIA [cytosol] (Sus scrofa)
phospho-Ub-21,22-p-S32,S36-NFKBIA [cytosol] (Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-serine at 32
Coordinate
32
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 36
Coordinate
36
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
ubiquitinylated lysine at 21
Coordinate
21
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine at 22
Coordinate
22
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
OpenTargets
ZINC - Substances
GeneCards
ZINC target
PRO
ZINC - Predictions - Purchasable
Orphanet
PDB
Interactors (37)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q04206 RELA  6 0.973 24
 UniProt:O14920 IKBKB  3 0.969 27
 UniProt:O15111 CHUK  3 0.95 15
 UniProt:P19838 NFKB1  8 0.88 7
 UniProt:Q9Y6K9 IKBKG  12 0.845 6
 UniProt:Q9NWT6 HIF1AN  1 0.734 6
 IntAct:EBI-4399559 UBIQ      0.722 3
 IntAct:EBI-10826665 NKILA      0.706 15
 UniProt:P23396 RPS3  2 0.677 6
 UniProt:Q04864 REL  2 0.669 4
 UniProt:P0CG48 UBC  334 0.656 3
 UniProt:Q04206-1 RELA      0.611 6
 UniProt:P21530-PRO_0000038062      0.593 4
 UniProt:Q9J0X9 Q9J0X9      0.591 3
 UniProt:P25963 NFKBIA  10 0.589 3
 UniProt:Q04207  6 0.589 2
 UniProt:P35221 CTNNA1  2 0.576 5
 UniProt:Q8N668 COMMD1  2 0.576 3
 UniProt:Q04206-2 RELA      0.564 3
 UniProt:O00411 POLRMT  1 0.564 2
 UniProt:Q9UKB1 FBXW11  1 0.564 2
 UniProt:Q01201 RELB  2 0.564 2
 UniProt:Q9Y297 BTRC  2 0.564 2
 UniProt:Q00653 NFKB2  8 0.564 3
 UniProt:P25098 GRK2  4 0.558 2
 UniProt:P34947 GRK5  1 0.558 2
 UniProt:Q14511 CASL      0.556 3
 UniProt:P14340-PRO_0000037965      0.524 2
 UniProt:P14340 POLG      0.524 2
 UniProt:Q9E7P0 Q9E7P0      0.508 2
 UniProt:P25799-1 NFKB1      0.499 2
 UniProt:P56279 TCL1A      0.488 2
 UniProt:Q9H0I2 ENKD1      0.488 2
 UniProt:Q14511-2 NEDD9      0.488 2
 UniProt:Q96HA1-2 POM121      0.488 2
 UniProt:O43242 PSMD3  5 0.488 2
 UniProt:P27986 PIK3R1  15 0.462 2