CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK

Stable Identifier
R-HSA-1168637
Type
Reaction [omitted]
Species
Homo sapiens
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TAK1 and the IKK complex are observed to migrate from the cytosol to lipid rafts containing the CARMA1:BCL10:MALT1 (CBM) complex (Sommer et al. 2005, Shinohara et al. 2005 using chicken cells). By analogy with activation of NF-KappaB signaling in T cells, TAK1 in B cells may also be bound to TAB1 and TAB2 or TAB3, which bind K63-conjugated polyubiquitin on a TRAF protein bound to the CBM complex (reviewed in Shinohara et al. 2009).

Literature References
PubMed ID Title Journal Year
16301747 PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1

Shinohara, H, Yasuda, T, Aiba, Y, Sanjo, H, Hamadate, M, Watarai, H, Sakurai, H, Kurosaki, T

J Exp Med 2005
16356855 Phosphorylation of the CARMA1 linker controls NF-kappaB activation

Sommer, K, Guo, B, Pomerantz, JL, Bandaranayake, AD, Moreno-Garcia, ME, Ovechkina, YL, Rawlings, DJ

Immunity 2005
19909372 Comprehending the complex connection between PKCbeta, TAK1, and IKK in BCR signaling

Shinohara, H, Kurosaki, T

Immunol Rev 2009
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