Ubiquitinated IkB is degraded

Stable Identifier
R-HSA-1168640
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Phosphorylated, ubiquitinated IkB is degraded by the proteasome (Miyamoto et al. 1994, Traenckner et al. 1994, Alkalay et al. 1995, DiDonato et al. 1995, Li et al. 1995, Lin et al. 1995, Scherer et al. 1995, Chen et al. 1995). IkB does not dissociate from NF-kB before it is proteolyzed (Miyamoto et al. 1994, Traenckner et al. 1994, DiDonato et al. 1995, Lin et al. 1995).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
Activity
Orthologous Events