Ubiquitinated IkB is degraded

Stable Identifier
R-HSA-1168640
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Phosphorylated, ubiquitinated IkB is degraded by the proteasome (Miyamoto et al. 1994, Traenckner et al. 1994, Alkalay et al. 1995, DiDonato et al. 1995, Li et al. 1995, Lin et al. 1995, Scherer et al. 1995, Chen et al. 1995). IkB does not dissociate from NF-kB before it is proteolyzed (Miyamoto et al. 1994, Traenckner et al. 1994, DiDonato et al. 1995, Lin et al. 1995).

Literature References
PubMed ID Title Journal Year
7957109 A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B

Traenckner, EB, Wilk, S, Baeuerle, PA

EMBO J 1994
7575604 Inactivation of NF-kappa B inhibitor I kappa B alpha: ubiquitin-dependent proteolysis and its degradation product

Li, CC, Dai, RM, Longo, DL

Biochem Biophys Res Commun 1995
7628694 Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

Chen, Z, Hagler, J, Palombella, VJ, Melandri, F, Scherer, D, Ballard, D, Maniatis, T

Genes Dev 1995
7809113 Tumor necrosis factor alpha-induced phosphorylation of I kappa B alpha is a signal for its degradation but not dissociation from NF-kappa B

Miyamoto, S, Maki, M, Schmitt, MJ, Hatanaka, M, Verma, IM

Proc Natl Acad Sci U S A 1994
7862124 Phosphorylation of I kappa B alpha precedes but is not sufficient for its dissociation from NF-kappa B

DiDonato, JA, Mercurio, F, Karin, M

Mol Cell Biol 1995
7479976 Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination

Scherer, DC, Brockman, JA, Chen, Z, Maniatis, T, Ballard, DW

Proc Natl Acad Sci U S A 1995
7831327 Activation of NF-kappa B requires proteolysis of the inhibitor I kappa B-alpha: signal-induced phosphorylation of I kappa B-alpha alone does not release active NF-kappa B

Lin, YC, Brown, K, Siebenlist, U

Proc Natl Acad Sci U S A 1995
7479848 Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway

Alkalay, I, Yaron, A, Hatzubai, A, Orian, A, Ciechanover, A, Ben-Neriah, Y

Proc Natl Acad Sci U S A 1995
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed